Gender-Dependent Reproductive Toxicity of Copper Metal-Organic Frameworks and Attenuation by Surface Modification

Nanoscale ◽  
2021 ◽  
Author(s):  
Xiaotian Ji ◽  
Yousheng Mo ◽  
Haishan Li ◽  
Wanling Zhao ◽  
Aiqi Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Reproductive System ◽  
Metal Organic Frameworks ◽  
Reproductive Toxicity ◽  
Disease Diagnosis ◽  
Copper Metal ◽  
Diagnosis And Therapy ◽  
Metal Organic

Metal-organic frameworks (MOFs) as promising materials have been widely used in drug delivery, disease diagnosis and therapy, however, their effects on reproductive system remains unknown, which hinders their further clinical...

scholarly journals Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Author(s):  
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Chemical Engineering ◽  
Metal Organic Frameworks ◽  
Disease Diagnosis ◽  
Inorganic Materials ◽  
Synthesis Methods ◽  
High Porosity ◽  
Wide Range ◽  
Metal Organic

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

scholarly journals Recent Bio-Advances in Metal-Organic Frameworks

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1291 ◽  
Author(s):  
Isobel Tibbetts ◽  
George Kostakis
Keyword(s):  
Drug Delivery ◽  
Inorganic Material ◽  
Metal Organic Frameworks ◽  
Gas Storage ◽  
Industrial Applications ◽  
Biologically Relevant ◽  
Bioinspired Materials ◽  
Synthesis Properties ◽  
Metal Organic

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

scholarly journals A novel route to size-controlled MIL-53(Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10540-10547
Author(s):  
Anxia Li ◽  
Xiaoxin Yang ◽  
Juan Chen
Keyword(s):  
Drug Delivery ◽  
Therapeutic Approach ◽  
Metal Organic Frameworks ◽  
Ionic Surfactant ◽  
Controlled Synthesis ◽  
New Approach ◽  
Metal Organic ◽  
Size Controlled

In this study, we reported a new approach for the size-controlled synthesis of uniform iron(iii)-based MIL-53 nanocrystals using the non-ionic surfactant PVP. A combinational therapeutic approach was presented for drug delivery and ROS therapy.

scholarly journals Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 722
Author(s):  
Ioanna Christodoulou ◽  
Tom Bourguignon ◽  
Xue Li ◽  
Gilles Patriarche ◽  
Christian Serre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Degradation Mechanism ◽  
Metal Organic Frameworks ◽  
Porous Metal ◽  
Force Microscopy ◽  
Atomic Force ◽  
Metal Organic ◽  
The Media ◽  
Ph Conditions

In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs’ stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.

scholarly journals Advances in Functional Metal‐Organic Frameworks Based On‐Demand Drug Delivery Systems for Tumor Therapeutics

2021 ◽  
pp. 2100014
Author(s):  
Bhanu Nirosha Yalamandala ◽  
Wei‐Ting Shen ◽  
Sheng‐Hao Min ◽  
Wen‐Hsuan Chiang ◽  
Shing‐Jyh Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
On Demand ◽  
Metal Organic

Metal–Organic Frameworks as Efficient Materials for Drug Delivery

2006 ◽  
Vol 118 (36) ◽  
pp. 6120-6124 ◽  
Author(s):  
Patricia Horcajada ◽  
Christian Serre ◽  
María Vallet-Regí ◽  
Muriel Sebban ◽  
Francis Taulelle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Metal Organic
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