The Core Composition of DNA Block Copolymer Micelles Dictates DNA Hybridization Properties, Nuclease Stabilities, and Cellular Uptake Efficiencies

Nanoscale ◽  
2021 ◽  
Author(s):  
Chan-Jin Kim ◽  
Ga-Hyun Kim ◽  
Eun Hye Jeong ◽  
Hyukjin Lee ◽  
So-Jung Park
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Cellular Uptake ◽  
Molecular Interactions ◽  
Dna Hybridization ◽  
Hydrophobic Core ◽  
The Core ◽  
Core Composition ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Here, we report how the nature of the hydrophobic core affects molecular interactions of DNA block copolymer assemblies. Three different amphiphilic DNA block copolymers, DNA-b-polystyrene (DNA-b-PS), DNA-b-poly(2-vinylpyridine) (DNA-b-P2VP), and DNA-b-poly(methyl...

scholarly journals Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques

2021 ◽  
Author(s):  
Isamu Akiba ◽  
Kazuo Sakurai
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Static Solution ◽  
Theoretical Background ◽  
Hydrophobic Drugs ◽  
Safety And Efficacy ◽  
Critical Quality Attributes ◽  
Regulatory Authorities ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

AbstractBlock copolymers are well recognized as excellent nanotools for delivering hydrophobic drugs. The formulation of such delivery nanoparticles requires robust characterization and clarification of the critical quality attributes correlating with the safety and efficacy of the drug before applying to regulatory authorities for approval. Static solution scattering from block copolymers is one such technique. This paper first outlines the theoretical background and current models for analyzing this scattering and then presents an overview of our recent studies on block copolymers.

scholarly journals Cellular Uptake of DNA Block Copolymer Micelles with Different Shapes

2008 ◽  
Vol 29 (4) ◽  
pp. 326-329 ◽  
Author(s):  
Fikri E. Alemdaroglu ◽  
N. Ceren Alemdaroglu ◽  
Peter Langguth ◽  
Andreas Herrmann
Keyword(s):  
Block Copolymer ◽  
Cellular Uptake ◽  
Block Copolymer Micelles ◽  
Different Shapes ◽  
Copolymer Micelles

Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform

2017 ◽  
Vol 46 (3) ◽  
pp. 569-585 ◽  
Author(s):  
Dechao Niu ◽  
Yongsheng Li ◽  
Jianlin Shi
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Hybrid Materials ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Design Synthesis ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Silica/organosilica cross-linked block copolymer micelles are a novel class of hybrid materials that combine the advantages of amphiphilic block copolymers and silica/organosilica cross-linking agents into one unit. This Tutorial Review summarizes the recent progress in the design, synthesis and biomedical applications of various silica/organosilica cross-linked block copolymer micelles.

Aggregation-induced emission from the crowded coronal chains of block copolymer micelles

2020 ◽  
Vol 11 (29) ◽  
pp. 4706-4713 ◽  
Author(s):  
Siyu Wang ◽  
Bixin Jin ◽  
Gangfeng Chen ◽  
Yunjun Luo ◽  
Xiaoyu Li
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
The Self ◽  
Assembly Process ◽  
Spatial Confinement ◽  
Aggregation Induced Emission ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Aggregation-induced emission (AIE) was triggered via the spatial confinement in the coronal chains in block copolymers upon micellization, even with very low content of AIE groups attached, and this could be used to monitor the self-assembly process.

Superior proapoptotic activity of curcumin-loaded mixed block copolymer micelles with mitochondrial targeting properties

2018 ◽  
Vol 6 (12) ◽  
pp. 3309-3317 ◽  
Author(s):  
Denitsa Momekova ◽  
Iva Ugrinova ◽  
Marta Slavkova ◽  
Georgi Momekov ◽  
Georgy Grancharov ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Mixed Block ◽  
Mitochondrial Targeting ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Multifunctional micelles based on two co-assembled block copolymers are proven to effectively accumulate and deliver curcumin in mitochondria, thus, inducing a much higher proapoptotic activity than single copolymer micelles.

scholarly journals Freezing-induced ordering of block copolymer micelles

2014 ◽  
Vol 50 (83) ◽  
pp. 12572-12574 ◽  
Author(s):  
Jérémy Dhainaut ◽  
Giulia Piana ◽  
Sylvain Deville ◽  
Christian Guizard ◽  
Michaela Klotz
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Assembly Process ◽  
Silica Monoliths ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Ice Templating

Silica monoliths presenting both hierarchical and mesostructured porosity were obtained by the combination of ice-templating and block-copolymers following a freezing-induced self-assembly process.

Intensely phosphorescent block copolymer micelles containing gold(i) complexes

Soft Matter ◽  
2018 ◽  
Vol 14 (18) ◽  
pp. 3521-3527 ◽  
Author(s):  
Pingxia Guo ◽  
Qun He ◽  
Chen Wang ◽  
Zaili Hou ◽  
Bingran Yu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Luminescence Enhancement ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Cationic Gold

Micellization of anionic block copolymers with cationic gold(i) complexes induces remarkable phosphorescence enhancement in solution. The extent of the luminescence enhancement increases with increasing molecular weight of the anionic block.

Salt-Induced Block Copolymer Micelles as Nanoreactors for the Formation of CdS Nanoparticles

2001 ◽  
Vol 703 ◽  
Author(s):  
Hanying Zhao ◽  
Elliot P. Douglas
Keyword(s):  
Block Copolymer ◽  
Ph Value ◽  
Cadmium Acetate ◽  
Cds Nanoparticles ◽  
The Core ◽  
Transmission Electron ◽  
Block Copolymer Micelles ◽  
Uv Visible ◽  
Copolymer Micelles ◽  
Location Change

ABSTRACTA novel preparation method of CdS nanoparticles in the core or corona of micelles is presented. Poly(styrene-block-2-vinylpyridine) (PS-b-P2VP) and cadmium ions form aggregates of single micelles, called compound micelles, upon addition of the cadmium acetate salt into a solution of the block copolymer in tetrahydrofuran. The growth of CdS nanoparticles is confined to the core of single micelles after introduction of hydrogen sulfide gas into the solution. UV-visible spectroscopy, fluorescence spectroscopy, and transmission electron microscopy were employed to characterize the prepared core-embedded CdS nanoparticles. Corona-embedded CdS nanoparticles were prepared by dropping the core-embedded CdS nanoparticles into water with a low pH value. The location change of the CdS nanoparticles was accompanied by a structural change of the micelles, a change from compound micelles to single micelles. In a single micelle, CdS nanoparticles distribute randomly in the corona. The size of the nanoparticles increases slightly after the transition.

Shaping block copolymer micelles by supramolecular polymerization: making ‘tubisomes’

2019 ◽  
Vol 10 (20) ◽  
pp. 2616-2625 ◽  
Author(s):  
Johannes C. Brendel ◽  
Sylvain Catrouillet ◽  
Joaquin Sanchis ◽  
Katrina A. Jolliffe ◽  
Sébastien Perrier
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Cyclic Peptide ◽  
Peptide Conjugates ◽  
Cylindrical Micelles ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Supramolecular Polymerization

In contrast to the respective block copolymers, amphiphilic cyclic peptide conjugates self-assemble into cylindrical micelles independent of the polymer compositions.

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