In situ formation of near-infrared controlled dual-antibacterial platform

2022 ◽  
Author(s):  
Zhuoyao Ni ◽  
jiajie hu ◽  
Hui Zhu ◽  
Yazhuo Shang ◽  
Daijie Chen ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Near Infrared ◽  
In Situ Formation

Antibiotic resistance caused by long-term abuse of antibiotics has inevitably become a very serious problem and developing novel strategies to enhance the efficacy of treatments is exigent. Herein, a dual-antibacterial...

Reduction of bioaccessibility of As in soil through in situ formation of amorphous Fe oxides and its long-term stability

2020 ◽  
Vol 745 ◽  
pp. 140989
Author(s):  
Jinhee Park ◽  
Jinsung An ◽  
Hyeonyong Chung ◽  
Sang Hyun Kim ◽  
Kyoungphile Nam
Keyword(s):  
Term Stability ◽  
Long Term Stability ◽  
Fe Oxides ◽  
In Situ Formation

The Orbital Architecture of Exoplanetary Systems

2020 ◽  
Author(s):  
John C. B. Papaloizou
Keyword(s):  
Central Star ◽  
Protoplanetary Disk ◽  
Dynamical Instability ◽  
Radial Migration ◽  
Exoplanetary Systems ◽  
Resonant Systems ◽  
In Situ Formation ◽  
Mutual Gravitational Interactions

The great diversity of extrasolar planetary systems has challenged our understanding of how planets form. During the formation process their orbits are modified while the protoplanetary disk is present. After its dispersal orbits may also be modified as a result of mutual gravitational interactions leading to their currently observed configurations in the longer term. A number of potentially significant phenomena have been identified. These include radial migration of solids in the protoplanetary disk, radial migration of protoplanetary cores produced by disk-planet interaction and how it can be halted by protoplanet traps, formation of resonant systems and subsystems, and gravitational interactions among planets or between a planet and an external stellar companion. These interactions may cause excitation of orbital inclinations and eccentricities which in the latter case may attain values close to unity. When the eccentricity approaches unity, tidal interaction with the central star could lead to orbital circularization and a close orbiting Hot Jupiter, providing a competitive process to direct migration through the disk or in-situ formation. Long-term dynamical instability may also account for the relatively small number of observed compact systems of super-Earths and Neptune class planets that have attained and subsequently maintained linked commensurabilities in the long term.

scholarly journals Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.

1983 ◽  
Vol 158 (5) ◽  
pp. 1739-1744 ◽  
Author(s):  
M Brownlee ◽  
S Pongor ◽  
A Cerami
Keyword(s):  
Immune Complexes ◽  
Structural Proteins ◽  
Covalent Attachment ◽  
Nonenzymatic Glycosylation ◽  
Collagen Binding ◽  
Free Antibody ◽  
In Situ Formation ◽  
Immune Complex Formation

The chronic tissue damage associated with long-term diabetes mellitus may arise in part from in situ immune complex formation by accumulated immunoglobulins and/or antigens bound to long-lived structural proteins that have undergone excessive nonenzymatic glycosylation. In this report, we have tested this hypothesis using nonenzymatically glycosylated collagen. Binding of both albumin and IgG averaged four times the amount bound to unmodified collagen. Both albumin and IgG (anti-BSA) bound to nonenzymatically glycosylated collagen retained their ability to form immune complexes in situ with free antibody and antigen.

scholarly journals Remote sensing of water vapour profiles in the framework of the Total Carbon Column Observing Network (TCCON)

2010 ◽  
Vol 3 (4) ◽  
pp. 3987-4007
Author(s):  
M. Schneider ◽  
E. Sepúlveda ◽  
O. García ◽  
F. Hase ◽  
T. Blumenstock
Keyword(s):  
Water Vapour ◽  
Near Infrared ◽  
Total Carbon ◽  
Solar Absorption ◽  
Upper Troposphere ◽  
High Measurement ◽  
The Vertical Distribution

Abstract. We show that the near infrared solar absorption spectra recorded in the framework of the Total Carbon Column Observing Network (TCCON) can be used to derive the vertical distribution of tropospheric water vapour. Using spectral H2O signatures in the 4500–4700 cm−1 region one can well distinguish lower from middle/upper tropospheric water vapour concentrations. The vertical resolution is about 3 and 6 km, for the lower and middle/upper troposphere, respectively. We document the quality of the remotely-sensed profiles by comparisons with coincident in-situ Vaisala RS92 radiosonde measurements. The agreement of both techniques is very satisfactory. Due to the long-term strategy of the network and the high measurement frequency, the TCCON water vapour profile data offer novel opportunities for estimating the water vapour variability at different time scales and altitudes.

Atmospheric Carbon Dioxide and Methane measurements at Sodankylä, Finland

2020 ◽  
Author(s):  
Rigel Kivi ◽  
Huilin Chen ◽  
Juha Hatakka ◽  
Pauli Heikkinen ◽  
Tuomas Laurila ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Atmospheric Carbon Dioxide ◽  
Near Infrared ◽  
Relative Difference ◽  
Total Carbon ◽  
Finnish Meteorological Institute ◽  
Infrared Spectral ◽  
Good Agreement

<p>Carbon dioxide and methane column measurement at the Finnish Meteorological Institute’s Sodankylä facility in northern Finland started in early 2009. The measurements have been taken by a Fourier Transform Spectrometer (FTS) in the near-infrared spectral region. From the spectra column-averaged abundances of CO<sub>2</sub>, CH<sub>4</sub> and other gases are derived. The instrument participates in the Total Carbon Column Observing Network (TCCON).  Here we present long-term ground based FTS measurements of carbon dioxide and methane and comparisons with satellite borne observations. We find that CO<sub>2</sub> column amounts have increased by 2.2 ± 0.1 ppm/year since the start of the measurements in 2009 and CH<sub>4</sub> column amounts have increased by 7 ± 0.4 ppb/year. The measurements are in good agreement with multi-year measurements by the Greenhouse Gases Observing Satellite (GOSAT): the relative difference in XCH<sub>4</sub> has been -0.07 ± 0.02 % and the relative difference in XCO<sub>2</sub> has been 0.04 ± 0.02 %. Finally we use balloon borne AirCore observations at the Sodankylä site to provide comparisons between FTS and in situ observations during all seasons.</p>

In situ formation of CsPbBr3/ZnO bulk heterojunctions towards photodetectors with ultrahigh responsivity

2018 ◽  
Vol 6 (45) ◽  
pp. 12164-12169 ◽  
Author(s):  
Yalong Shen ◽  
Chao Wei ◽  
Lianbo Ma ◽  
Shalong Wang ◽  
Xiong Wang ◽  
...  
Keyword(s):  
Bulk Heterojunctions ◽  
Solution Processed ◽  
Imaging Capability ◽  
Term Stability ◽  
Long Term Stability ◽  
In Situ Formation

A solution-processed hybrid photodetector based on in situ formed CsPbBr3/ZnO bulk heterojunctions exhibited ultrahigh responsivity, long-term stability and desirable imaging capability.

scholarly journals A de novo strategy to develop NIR precipitating fluorochrome for long-term in situ cell membrane bioimaging

2021 ◽  
Vol 118 (8) ◽  
pp. e2018033118
Author(s):  
Ke Li ◽  
Yifan Lyu ◽  
Yan Huang ◽  
Shuai Xu ◽  
Hong-Wen Liu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
De Novo ◽  
Membrane Surface ◽  
In Situ Monitoring ◽  
Fluorescence Signal ◽  
In Situ Imaging

Cell membrane–targeted bioimaging is a prerequisite for studying the roles of membrane-associated biomolecules in various physiological and pathological processes. However, long-term in situ bioimaging on the cell membrane with conventional fluorescent probes leads to diffusion into cells from the membrane surface. Therefore, we herein proposed a de novo strategy to construct an antidiffusion probe by integrating a fluorochrome characterized by strong hydrophobicity and low lipophilicity, with an enzyme substrate to meet this challenge. This precipitating fluorochrome HYPQ was designed by conjugating the traditionally strong hydrophobic solid-state fluorochrome 6-chloro–2-(2-hydroxyphenyl) quinazolin-4(3H)-one (HPQ) with a 2-(2-methyl–4H-chromen–4-ylidene) malononitrile group to obtain closer stacking to lower lipophilicity and elongate emission to the far-red to near-infrared wavelength. As proof-of-concept, the membrane-associated enzyme γ-glutamyltranspeptidase (GGT) was selected as a model enzyme to design the antidiffusion probe HYPQG. Then, benefiting from the precipitating and stable signal properties of HYPQ, in situ imaging of GGT on the membrane was successfully realized. Moreover, after HYPQG was activated by GGT, the fluorescence signal on the cell membrane remained unchanged, with incubation time even extending to 6 h, which is significant for in situ monitoring of enzymatic activity. In vivo testing subsequently showed that the tumor region could be accurately defined by this probe after long-term in situ imaging of tumor-bearing mice. The excellent performance of HYPQ indicates that it may be an ideal alternative for constructing universal antidiffusion fluorescent probes, potentially providing an efficient tool for accurate imaging-guided surgery in the future.

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