Name Reactions: Strategies in Design of Chemodosimeters for Analyte Detection

2021 ◽  
Author(s):  
Ajit Kumar Mahapatra ◽  
Anwesha Maiti ◽  
Saikat Kumar Manna ◽  
Dipanjan Banik
Keyword(s):  
Molecular Recognition ◽  
Chemical Reactions ◽  
Design And Synthesis ◽  
Analyte Detection

Design and synthesis of suitable chemodosimeters for detection of toxic analytes has become challenging for new researchers nowadays in the molecular recognition field. Among different chemical reactions, name reaction-based approaches...

Design and synthesis of imidazolinium salts derived from (l)-valine. Investigation of their potential in chiral molecular recognition

2004 ◽  
pp. 1224-1225 ◽  
Author(s):  
Hervé Clavier ◽  
Loïse Boulanger ◽  
Nicolas Audic ◽  
Loïc Toupet ◽  
Marc Mauduit ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Design And Synthesis ◽  
Chiral Molecular Recognition ◽  
Imidazolinium Salts

scholarly journals Design and synthesis of a new tricyclic scaffold for molecular recognition

1997 ◽  
Vol 38 (45) ◽  
pp. 7911-7912 ◽  
Author(s):  
Juana Robles Caycho ◽  
Fernando García-Tellado ◽  
Pedro de Armas ◽  
Jose Juan Marrero-Tellado
Keyword(s):  
Molecular Recognition ◽  
Design And Synthesis

Design and Synthesis of Imidazolinium Salts Derived from (L)-Valine. Investigation of Their Potential in Chiral Molecular Recognition.

ChemInform ◽  
2004 ◽  
Vol 35 (40) ◽  
Author(s):  
Herve Clavier ◽  
Loise Boulanger ◽  
Nicolas Audic ◽  
Loic Toupet ◽  
Marc Mauduit ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Design And Synthesis ◽  
Chiral Molecular Recognition ◽  
Imidazolinium Salts

scholarly journals Minimalist proteins: Design of new molecular recognition scaffolds

2004 ◽  
Vol 76 (7-8) ◽  
pp. 1579-1590 ◽  
Author(s):  
J. A. Shin
Keyword(s):  
Dna Binding ◽  
Molecular Recognition ◽  
Leucine Zipper ◽  
Alpha Helix ◽  
Helical Structure ◽  
Binding Specificity ◽  
Mutant Proteins ◽  
Coulombic Interactions ◽  
Design And Synthesis ◽  
Binding Specificity And Affinity

We hypothesize that we can exploit what Nature has already evolved by manipulating the alpha-helix molecular recognition scaffold. Therefore, minimalist proteins capable of sequence-specific, high-affinity binding of DNA were generated to probe how proteins are used and can be used to recognize DNA. The already minimal basic region/leucine zipper motif (bZIP) of GCN4 was reduced to an even more simplified structure by substitution with alanine residues —hence, a generic, Ala-based, helical scaffold. The proteins generated, wt bZIP, 4A,11A, and 18A, contain 0, 4, 11, and 18 alanine mutations in their DNA-binding basic regions, respectively. All alanine mutants still retain alpha-helical structure and DNA-bind- ing function, despite loss of virtually all Coulombic protein-DNA interactions. Mass spectrometry allowed characterization of proteins and post-translational modifications. Fluorescence anisotropy and DNase I footprinting were used to measure in situ binding of these mutant proteins to DNA duplexes containing target sites AP-1 (5'-TGACTCA-3'), ATF/CREB (5'-TGACGTCA-3'),or nonspecific DNA. The roles of van der Waals and Coulombic interactions toward binding specificity and affinity are being investigated. Thus, both DNA-binding specificity and affinity are maintained in all our bZIP derivatives. This Ala-rich scaffold may be useful in design and synthesis of small, alpha-helical proteins with desired DNA-recognition properties.

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