Ethidium bromide-bridged mesoporous silica hybrid nanocarriers for fluorescent cell imaging and drug delivery applications

2021 ◽  
Author(s):  
Seong-Cheol Kim ◽  
Madhappan Santha Moorthy ◽  
Kokila Thirupathi ◽  
Thirukumaran Periyasamy ◽  
Dinakaran Thirumalai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Ethidium Bromide ◽  
Cell Imaging ◽  
Fluorescent Cell ◽  
Drug Delivery Applications ◽  
Silica Hybrid

Mesoporous silica nanocarriers with dual/multifunctionalities are thought to be good candidates for dual/multimodal applications such as the combined drug delivery and bioimaging. In this study, a new red fluorescent organosilica...

Mesoporous silica coated Gd2(CO3)3:Eu hollow nanospheres for simultaneous cell imaging and drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62320-62326 ◽  
Author(s):  
Yanli Wu ◽  
Xianzhu Xu ◽  
Xi Chen ◽  
Ruchun Yang ◽  
Qiang Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mr Imaging ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Hollow Structure ◽  
Hollow Nanospheres

The efficient optical/MR imaging capabilities, and the hollow structure make Gd2(CO3)3:Eu@mSiO2 a promising platform for simultaneous bioimaging and drug delivery.

AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

2016 ◽  
Vol 22 (11) ◽  
pp. 3681-3685 ◽  
Author(s):  
Zhiying Fan ◽  
Dongdong Li ◽  
Xue Yu ◽  
Yuping Zhang ◽  
Yong Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Silica Nanospheres ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Synthesis of urea-pyridyl ligand functionalized mesoporous silica hybrid material for hydrophobic and hydrophilic drug delivery application

2017 ◽  
Vol 25 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Yunok Oh ◽  
Bian Jang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Hybrid Material ◽  
Drug Delivery Application ◽  
Functionalized Mesoporous Silica ◽  
Hydrophilic Drug ◽  
Pyridyl Ligand ◽  
Silica Hybrid

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

Synthesis of Fe3O4 modified mesoporous silica hybrid for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 25 (4) ◽  
pp. 1251-1264 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Yunok Oh ◽  
Thi Tuong Vy Phan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Magnetic Hyperthermia ◽  
Ph Responsive ◽  
Silica Hybrid

scholarly journals Role of mesoporous silica nanoparticles for the drug delivery applications

2020 ◽  
Vol 7 (10) ◽  
pp. 102002
Author(s):  
Baranya Murugan ◽  
Suresh Sagadevan ◽  
Anita Lett J ◽  
Is Fatimah ◽  
Kamrun Nahar Fatema ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Delivery Applications

Evaluation of Potential of Uncoated Mesoporous Silica Particles for Drug Delivery Applications

2021 ◽  
Vol 875 ◽  
pp. 366-372
Author(s):  
Tayyab Ali Khan ◽  
Syed Mujtaba Ul Hassan ◽  
Hassan Waqas ◽  
Jamil Ahmad ◽  
Ahmat Khurshid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Cancer Cell Line ◽  
Silica Particles ◽  
Atomic Force ◽  
Drug Delivery Applications ◽  
Model Drug ◽  
Average Size

The drug loading capability and inherent cytotoxicity of mesoporous silica particles are two prime considerations for targeted drug delivery applications. In current study, uncoated mesoporous silica (UMS) carrier particles were synthesized by sol-gel emulsion approach. The morphology and structure of UMS was thoroughly characterized using atomic force microscope (AFM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Brunauer–Emmett–Teller (BET). The scanning electron microscopy (SEM) and dynamic light scattering (DLS) measurements reveal that mono dispersed silica particles have an average size of 250 nm with narrow size distribution. The pore size was measured as 47nm. Concentration dependent biocompatibility of UMS was evaluated using MTT assay with Hep-2c cancer cell line and cell viability of ~65% at concentrations of 7.5 nM was observed. Finally, the drug loading capability of UMS carrier was studied using ibuprofen as a model drug.

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