Application of Organometallic Catalysts for the Synthesis of o-Tolyl Benzonitrile, a Key Starting Material for Sartans

2021 ◽  
Author(s):  
SHARADA PRASANNA SWAIN ◽  
Anupam Jana ◽  
Velayutham Ravichandiran
Keyword(s):  
Aromatic Compounds ◽  
Antifungal Drugs ◽  
Starting Material ◽  
Important Class ◽  
Organometallic Catalysts ◽  
Biaryl Compounds

Biaryl compounds are important class of aromatic compounds used for synthesis of antiviral, antihypertensive, antifungal drugs. The familiar methods for synthesis of biaryl compounds are Pd-, Ni-catalyzed couplings reactions such...

scholarly journals Allylation of Orthoquinones Towards Annulated Polycyclic Aromatic Systems

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2043 ◽  
Author(s):  
Mariusz Kędziorek ◽  
Liliana Dobrzańska
Keyword(s):  
Aromatic Compounds ◽  
Polycyclic Aromatic Compounds ◽  
Starting Material ◽  
Ring Closing Metathesis ◽  
One Pot ◽  
Pinacol Rearrangement ◽  
Polycyclic Aromatic ◽  
Aromatic Systems

Promising results of an efficient and convenient strategy for the annulation of polycyclic aromatic compounds (PACs), employing orthoquinones as starting material and comprising allylation, pinacol rearrangement, ring-closing metathesis (RCM), and one-pot reduction followed by Wagner-Meerwein rearrangement, are presented. The strategy involves introducing triallylborane prepared in situ in the allylation step. Moreover, a novel expedient method for the preparation of 9,10-diallylphenanthrene was introduced.

Eco-Friendly Methodologies for the Synthesis of Quinoline Nucleus

2019 ◽  
Vol 16 (6) ◽  
pp. 602-608 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Marcus V.N. de Souza
Keyword(s):  
Aromatic Compounds ◽  
Reaction Mechanisms ◽  
Reaction Scheme ◽  
Important Class ◽  
Reaction Conditions ◽  
Synthetic Methodologies

The quinoline nucleus is a very important class of heterocyclic aromatic compounds present in several drugs on the market, with synthetic methodologies being necessary to prepare its nucleus and derivatives. Considering that fact, the aim of this review is to describe the development of eco-friendly methodologies for the synthesis of quinoline nucleus and its derivatives in the last five years. Thus, throughout the text are presented varios reagents and catalysts used in the synthesis of quinoline nucleus, the reaction conditions, the advantages of the described methodologies, along with the reaction scheme and some reaction mechanisms.

Gold liposomes

1996 ◽  
Vol 54 ◽  
pp. 898-899
Author(s):  
James F. Hainfeld
Keyword(s):  
Direct Methods ◽  
Important Class ◽  
Double Bonds ◽  
Membrane Phospholipids ◽  
Essential Ingredient ◽  
Lipid Structures

Lipids are an important class of molecules, being found in membranes, HDL, LDL, and other natural structures, serving essential roles in structure and with varied functions such as compartmentalization and transport. Synthetic liposomes are also widely used as delivery and release vehicles for drugs, cosmetics, and other chemicals; soap is made from lipids. Lipids may form bilayer or multilammellar vesicles, micelles, sheets, tubes, and other structures. Lipid molecules may be linked to proteins, carbohydrates, or other moieties. EM study of this essential ingredient of life has lagged, due to lack of direct methods to visualize lipids without extensive alteration. OsO4 reacts with double bonds in membrane phospholipids, forming crossbridges. This has been the method of choice to both fix and stain membranes, thus far. An earlier work described the use of tungstate clusters (W11) attached to lipid moieties to form lipid structures and lipid probes.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

1679 Fatty acid profile, sensory traits, and aromatic compounds of chops from lambs fed ground woody plants as roughage in feedlot finishing diets

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 818-818
Author(s):  
K. R. Wall ◽  
C. R. Kerth ◽  
T. R. Whitney ◽  
S. B. Smith ◽  
J. L. Glasscock ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Aromatic Compounds ◽  
Woody Plants ◽  
Finishing Diets
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