An efficient transition-metal‐free route to quinazolin-4(3H)-ones via 2-aminobenzamides and thiols

2021 ◽  
Author(s):  
Yibo Dong ◽  
Jinli Zhang ◽  
Jinchen Yang ◽  
Congcong Yan ◽  
Yangjie Wu
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
One Pot ◽  
Metal Free ◽  
Efficient Approach

An efficient approach to quinazolin-4(3H)-ones was developed by one-pot intermolecular annulation reaction of o-amino benzamides and thiols. This method has the feature of good functional groups tolerance, transition-metal-free, external oxidant-free,...

KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones

2017 ◽  
Vol 4 (6) ◽  
pp. 1162-1166 ◽  
Author(s):  
Wenteng Chen ◽  
Xingyu Liu ◽  
En Chen ◽  
Binhui Chen ◽  
Jiaan Shao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Oxidative Coupling ◽  
One Pot ◽  
Metal Free ◽  
Efficient Approach ◽  
Vinyl Azides

Transition metal-free oxidative coupling of vinyl azides with sulfonyl hydrazines is described.

Iodine-promoted one pot reaction of pyridin-2-amine with arylmethyl ketone and selenosulfonate: synthesis of 3-(alkylselanyl)-2-arylimidazo[1,2-a]pyridine under transition-metal free conditions

2019 ◽  
Vol 6 (5) ◽  
pp. 654-659 ◽  
Author(s):  
Nan Jiang ◽  
Yi Fang ◽  
Yue Fang ◽  
Shun-Yi Wang ◽  
Shun-Jun Ji
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
Efficient Approach

A new efficient approach for the I2 promoted selenium functionalization of in situ generated imidazoheterocycles utilizing aliphatic selenosulfonate as the selenium source under transition metal-free conditions is developed.

scholarly journals An entry to 2-(cyclobut-1-en-1-yl)-1H-indoles through a cyclobutenylation/deprotection cascade

2021 ◽  
Author(s):  
Philipp Natho ◽  
Zeyu Yang ◽  
Lewis Allen ◽  
Juliette Rey ◽  
Andrew J P White ◽  
...  
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
Mild Conditions

A transition-metal-free strategy for the synthesis of 2-(cyclobut-1-en-1-yl)-1H-indoles under mild conditions is described herein. A series of substituted 2-(cyclobut-1-en-1-yl)-1H-indoles are accessed by a one-pot cyclobutenylation/deprotection cascade from N-Boc protected indoles....

ChemInform Abstract: Transition Metal Free Intramolecular S-Arylation: One-Pot Synthesis of Thiochromen-4-ones.

ChemInform ◽  
2014 ◽  
Vol 45 (13) ◽  
pp. no-no
Author(s):  
T. A. Jenifer Vijay ◽  
Kebbahalli N. Nandeesh ◽  
Goravanahalli M. Raghavendra ◽  
Kanchugarakoppal S. Rangappa ◽  
Kempegowda Mantelingu
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

Deuterative cyclization of sulfanyl 1,6-diynes: complete and monodeuteration of functional groups on heterocycles

2015 ◽  
Vol 2 (3) ◽  
pp. 201-205 ◽  
Author(s):  
Yukiteru Ito ◽  
Mitsuhiro Yoshimatsu
Keyword(s):  
Transition Metal ◽  
Exchange Reaction ◽  
Functional Groups ◽  
Reductive Cyclization ◽  
Metal Free ◽  
Sodium Borodeuteride

Regioselective H/D exchange reaction of functional groups on heterocycles proceeded via a transition metal-free reductive cyclization of sulfanyl 1,6-diynes using sodium borodeuteride/ethanol-D1.

scholarly journals Unsymmetrical Difunctionalization of Two Different C–H Bonds in One Pot Under Transition-Metal Catalysis

Synthesis ◽  
2018 ◽  
Vol 51 (01) ◽  
pp. 40-54 ◽  
Author(s):  
Masahito Murai ◽  
Kazuhiko Takai
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Aromatic Compounds ◽  
Transition Metal Catalysis ◽  
One Pot ◽  
Metal Catalysis ◽  
Selective Functionalization ◽  
Sequential Addition ◽  
Target Molecules ◽  
Directing Group

Recent advancements in unsymmetrical difunctionalization based on the substitution of two different C–H bonds in one-pot are described. Due to the difficulty of controlling reactivity and selectivity, multi-functionalization via substitution of several C–H bonds to install different functional groups has been limited until recently, in comparison with well-studied functionalization via sequential addition to unsaturated π-bonds. This difunctionalization protocol provides an efficient and rapid approach to a library of structurally complicated target molecules through the formation of multiple C–X bonds with high atom- and step-economy.1 Introduction2 ortho-Selective Functionalization of Two Different C–H Bonds Relative to the Directing Group2.1 Unsymmetrical Difunctionalization with the Introduction of Similar Functional Groups2.2 Unsymmetrical Difunctionalization with the Introduction of Different Functional Groups2.3 ortho-Selective Unsymmetrical Difunctionalization Promoted by Two Different Directing Groups Appearing During the Progress of the Reaction3 ortho/meta-Selective C–H Bond Difunctionalization Relative to the Directing Group4 Sequential Difunctionalization of Fused Aromatic Compounds and Heterocycles5 Summary and Outlook

ChemInform Abstract: A One-Pot Transition Metal Free Tandem Process to 1,4-Benzodiazepine Scaffolds.

ChemInform ◽  
2013 ◽  
Vol 44 (17) ◽  
pp. no-no
Author(s):  
Yanqiu Li ◽  
Chunjing Zhan ◽  
Bingchuan Yang ◽  
Xiaoqun Cao ◽  
Chen Ma
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
Tandem Process

One-pot synthesis of thioesters with sodium thiosulfate as a sulfur surrogate under transition metal-free conditions

2018 ◽  
Vol 16 (11) ◽  
pp. 1871-1881 ◽  
Author(s):  
Yen-Sen Liao ◽  
Chien-Fu Liang
Keyword(s):  
Transition Metal ◽  
Sodium Thiosulfate ◽  
Sulfur Source ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

We have developed a one-pot reaction to provide thioester derivativesviasodium thiosulfate as a sulfur source under transition metal-free conditions.

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