scholarly journals Interaction, binding capacity and anticancer properties of N,N′‐bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2

2021 ◽  
Author(s):  
Nikola Stevanovic ◽  
Danijela Apostolovic ◽  
Milos Milcic ◽  
Aleksandar Lolić ◽  
Marianne van Hage ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Biological Activity ◽  
Schiff Base ◽  
Binding Capacity ◽  
Cancer Cell Line ◽  
Biological Properties ◽  
Schiff Base Complexes ◽  
Colorectal Cancer Cell Line ◽  
Tetradentate Schiff Base ◽  
Anticancer Properties

Different Schiff base complexes have a biological activity that makes them suitable for drug design. The biological properties of the tetradentate Schiff base copper(II) complex with N,N′‐bis(acetylacetone)propylenediimine, has been studied....

scholarly journals Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes

2019 ◽  
Vol 48 (18) ◽  
pp. 5987-6002 ◽  
Author(s):  
A. Paden King ◽  
Hendryck A. Gellineau ◽  
Samantha N. MacMillan ◽  
Justin J. Wilson
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Physical Properties ◽  
Ligand Exchange ◽  
Ligand Substitution ◽  
Schiff Base Complexes ◽  
Substitution Reactions ◽  
Anticancer Properties ◽  
Ligand Substitution Reactions

A subset of fluorinated Co(iii) Schiff base complexes was synthesized, and their structural, ligand exchange, and anticancer properties were investigated.

Cytochalasan Alkaloids as TRAIL Sensitizers from an Endophytic Fungus Chaetomium sp.

Planta Medica ◽  
2021 ◽  
Author(s):  
Hanli Ruan ◽  
Ying Gao ◽  
Ruihua Mao ◽  
Ye Liu ◽  
Ming Zhou
Keyword(s):  
Colorectal Cancer ◽  
Absolute Configuration ◽  
Endophytic Fungus ◽  
Cancer Cell Line ◽  
Ring System ◽  
Ht29 Cell ◽  
Colorectal Cancer Cell Line ◽  
X Ray ◽  
Fibrous Roots ◽  
Trail Sensitivity

Two new cytochalasans with a rare 6/6/5/5/7 pentacyclic ring system, named chaetoconvosins C−D (1−2), together with two known congeners (3−4), were isolated from the fermentation of an endophytic fungus, Chaetomium sp. SG-01, harbored in the fibrous roots of Schisandra glaucescens Diels. Their structures including the absolute configuration were elucidated by extensive spectroscopic (HRESIMS, NMR, and ECD) and X-ray crystallographic analyses. The TRAIL sensitivity of 1–4 in a TRAIL-resistant HT29 colorectal cancer cell line was evaluated, which revealed that co-treatment of 1–4 at 50 µM with TRAIL (150 ng/mL) reduced the HT29 cell viability by 19.0%, 24.1%, 17.9%, and 15.5%, respectively, compared to treatment with 1–4 alone.

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