scholarly journals Novel insights into nanomaterials for immunomodulatory bone regeneration

2021 ◽  
Author(s):  
Ya Cui ◽  
Hairui Li ◽  
Yaxin Li ◽  
Lixia Mao
Keyword(s):  
Bone Regeneration ◽  
Congenital Malformation ◽  
Bone Defect ◽  
Immune Cells ◽  
Focus Of Attention ◽  
Systemic Diseases ◽  
Bone Defect Repair ◽  
Regeneration Medicine ◽  
Recent Advances ◽  
Defect Repair

Bone defect repair caused by trauma, congenital malformation, tumor, infection or systemic diseases remains the focus of attention in regeneration medicine. Recent advances in osteoimmunology indicate that immune cells and...

Enhanced Bone Regeneration and Bone Defect Repair Using Magnesium/Lithium-Co-Modified, Porous, Hydroxyapatite Composite Scaffolds

2020 ◽  
Vol 12 (1) ◽  
pp. 124-136
Author(s):  
Hai-Yan Zhao ◽  
Releken-Yeersheng ◽  
Ya-Yi Xia ◽  
Xing-Wen Han ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Biological Degradation ◽  
Porous Hydroxyapatite ◽  
Bone Defect Repair ◽  
Hydroxyapatite Composite ◽  
Defect Repair ◽  
Osteogenic Effect

Background: Hydroxyapatite (HA) has been frequently used in clinic, but it is hard to be degraded, and insufficient in osteogenesis and angiogenesis. This study aimed to modify HA by doping magnesium/lithium (Mg/Li) and assess the Mg/LiHA scaffold's bone regeneration and bone defect repair effects. Materials and Methods: The biomaterial was identified using XRD, FTIR and SEM. The porosity, cell mediated degradation behavior and mechanical property were investigated. Meanwhile, cell proliferation and adhesion were also exploited. Finally, osteogenic effect of Mg/LiHA scaffold in vitro, and bone defect repair effect in vivo were researched. Results: The results suggested that low-content of Mg/Li incorporation did not influence on the structure of HA. The cells mediated degradation experiments indicated that Mg/Li doped HA could improve the biological degradation and release the Mg2+ and Li+ sustainedly. The compressive strength of Mg/LiHA scaffolds with 63% porosity reached to 3.9 MPa. Cells proliferation and adhesion experiments demonstrated that Mg/LiHA scaffolds were beneficial to cell growth and attachment. Furthermore, Mg/LiHA scaffolds increased ALP expression, calcium phosphate deposition and VEGF expression in vitro. The bone defect repair in vivo was enhanced by using Mg/LiHA scaffolds. Conclusion: Mg/Li-co-substituted HA could enhance bone regeneration and bone defect repair, and may be recommended to further research on bone defect repair.

scholarly journals Cobalt-doped bioceramic scaffolds fabricated by 3D printing show enhanced osteogenic and angiogenic properties for bone repair

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jungang Li ◽  
Chaoqian Zhao ◽  
Chun Liu ◽  
Zhenyu Wang ◽  
Zeming Ling ◽  
...  
Keyword(s):  
Compressive Strength ◽  
3D Printing ◽  
Bone Regeneration ◽  
Doping Concentration ◽  
Artificial Bone ◽  
Bone Defect Repair ◽  
Co Doping ◽  
Defect Repair ◽  
Co Doped

Abstract Background The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus improve osteogenesis. We have previously revealed that crystalline Ca10Li(PO4)7 (CLP) possesses higher compressive strength and better biocompatibility than that of pure beta-tricalcium phosphate (β-TCP). In this work, we explored the possibility of cobalt (Co), known for mimicking hypoxia, doped into CLP to promote osteogenesis and angiogenesis. Methods We designed and manufactured porous scaffolds by doping CLP with various concentrations of Co (0, 0.1, 0.25, 0.5, and 1 mol%) and using 3D printing techniques. The crystal phase, surface morphology, compressive strength, in vitro degradation, and mineralization properties of Co-doped and -undoped CLP scaffolds were investigated. Next, we investigated the biocompatibility and effects of Co-doped and -undoped samples on osteogenic and angiogenic properties in vitro and on bone regeneration in rat cranium defects. Results With increasing Co-doping level, the compressive strength of Co-doped CLP scaffolds decreased in comparison with that of undoped CLP scaffolds, especially when the Co-doping concentration increased to 1 mol%. Co-doped CLP scaffolds possessed excellent degradation properties compared with those of undoped CLP scaffolds. The (0.1, 0.25, 0.5 mol%) Co-doped CLP scaffolds had mineralization properties similar to those of undoped CLP scaffolds, whereas the 1 mol% Co-doped CLP scaffolds shown no mineralization changes. Furthermore, compared with undoped scaffolds, Co-doped CLP scaffolds possessed excellent biocompatibility and prominent osteogenic and angiogenic properties in vitro, notably when the doping concentration was 0.25 mol%. After 8 weeks of implantation, 0.25 mol% Co-doped scaffolds had markedly enhanced bone regeneration at the defect site compared with that of the undoped scaffold. Conclusion In summary, CLP doped with 0.25 mol% Co2+ ions is a prospective method to enhance osteogenic and angiogenic properties, thus promoting bone regeneration in bone defect repair.

scholarly journals Bone defect repair on the alveolar wall of the maxillary sinus using collagen membranes and temporal fascia: an experimental study in monkeys

2011 ◽  
Vol 77 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Adalberto Novaes Silva ◽  
José Américo de Oliveira ◽  
Maria Célia Jamur ◽  
José Ari Gualberto Junqueira ◽  
Vani Maria Correa ◽  
...  
Keyword(s):  
Experimental Study ◽  
Maxillary Sinus ◽  
Bone Defect ◽  
Alveolar Wall ◽  
Bone Defect Repair ◽  
Temporal Fascia ◽  
Defect Repair ◽  
Collagen Membranes

Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

2021 ◽  
Author(s):  
Xinyun Zhai ◽  
Changshun Ruan ◽  
Jie Shen ◽  
Chuping Zheng ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Defect ◽  
Nanocomposite Hydrogel ◽  
Ion Release ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Gradual Release

Using nanoclay as the physical crosslinker, a novel clay-based nanocomposite hydrogel with attractive mechanical properties has be obtained, and the gradual release of intrinsic Mg2+ and Si4+ endows the system with excellent osteogenesis.

Injectable gel graft for bone defect repair

2014 ◽  
Vol 9 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Josephine Fang ◽  
Zhi Yang ◽  
ShihJye Tan ◽  
Charisse Tayag ◽  
Marcel E Nimni ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair

Nano-Hydroxyapatite Scaffold Based on Recombinant Human Bone Morphogenetic Protein 2 and Its Application in Bone Defect Repair

2021 ◽  
Vol 17 (7) ◽  
pp. 1330-1338
Author(s):  
Shibai Zhu ◽  
Xiaotian Zhang ◽  
Xi Chen ◽  
Yiou Wang ◽  
Shanni Li ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Artificial Bone ◽  
Bone Defect Repair ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Defect Repair ◽  
Hydroxyapatite Scaffold ◽  
Recombinant Human Bone

The best way in which to prepare scaffolds with good biological properties is an urgent problem in the field of tissue engineering. In this paper we discuss the preparation of nano-hydroxyapatite scaffold of recombinant human bone morphogenetic protein-2 (rhBMP-2) and its application in bone defect repair. rhBMP-2 reagent was dissolved in 1 mol/L sodium dihydrogen phosphate solution, and the rhBMP-2 solution was added to the nano-hydroxyapatite artificial bone with a 100 μL glass micro dropper at the rate of 10 drops/min to obtain Nano-HA/rhBMP-2 composite artificial bone. In in vivo experiments, rabbits were fixed on an operating table, a 2 cm longitudinal incision was made in the middle part of the radial forearm, and the radius was cut with a wire saw and periosteum, 2.5 cm away from the distal radius. After washing the wound with normal saline, Adv-hBMP-2/MC3T3-E1 nano-HA composite artificial bone, MC3T3-E1 nan-HA composite artificial bone, or Nano-HA artificial bone were implanted in different groups. The artificial bone scaffold prepared in this study has a stronger ability to repair bone defects than the alternatives, and is a promising prospect for the clinical treatment of bone defects.

Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging

2022 ◽  
Author(s):  
Xiaotao Xing ◽  
Haisen Huang ◽  
Xin Gao ◽  
Jian Yang ◽  
Qi Tang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair
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