scholarly journals Cooperative transport by flocking phototactic micromotors

2021 ◽  
Author(s):  
Jianhua Zhang ◽  
Fangzhi Mou ◽  
Zhen Wu ◽  
Jiaqi Song ◽  
Joshua E. Kauffman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
Environmental Cleaning ◽  
Cargo Delivery ◽  
Cooperative Transport

Cargo delivery by micro/nanomotors provides enormous opportunities for micromanipulation, environmental cleaning, and drug delivery, etc. However, due to the limited driving force, single micro/nanomotors are usually difficult to transport cargoes...

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

Fundamental Investigations of Driving Force of Microcapsule for Drug Delivery Systems Using the Principle of Neutrophile’s Chemotaxis

2007 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cytokine Concentration ◽  
Marangoni Effects

This paper describes the effects of gradient of cytokine concentration on chemotaxis of neutrophile by observing the motion in liquid with adding cytokine concentration. The aim of this investigation is to distinguish the driving force by Marangoni effects from amebic motion.

scholarly journals Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Micromachines ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 830 ◽  
Author(s):  
Hedieh Fallahi ◽  
Jun Zhang ◽  
Hoang-Phuong Phan ◽  
Nam-Trung Nguyen
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
Wearable Electronics ◽  
Fluid Structure Interactions ◽  
Future Perspectives ◽  
Research Areas ◽  
Technological Advances ◽  
Significant Interest ◽  
Recent Developments ◽  
Materials Used

Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they behave in a different way from rigid microchannels with fluid passing through them. This unique behaviour introduces new characteristics that can be deployed in microfluidic applications and functions such as valving, pumping, mixing, and separation. To date, a specialised review of flexible microfluidics that considers both the fundamentals and applications is missing in the literature. This review aims to provide a comprehensive summary including: (i) Materials used for fabrication of flexible microfluidics, (ii) basics and roles of flexibility on microfluidic functions, (iii) applications of flexible microfluidics in wearable electronics and biology, and (iv) future perspectives of flexible microfluidics. The review provides researchers and engineers with an extensive and updated understanding of the principles and applications of flexible microfluidics.

Improving the carrier stability and drug loading of unimolecular micelle-based nanotherapeutics for acid-activated drug delivery and enhanced antitumor therapy

2018 ◽  
Vol 6 (35) ◽  
pp. 5549-5561 ◽  
Author(s):  
Xiaoxiao Shi ◽  
Shuang Bai ◽  
Cangjie Yang ◽  
Xiaoqian Ma ◽  
Meili Hou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Antitumor Therapy ◽  
Therapeutic Efficiency ◽  
Cargo Delivery

Nanomedicines based on unimolecular micelles (UMs) have shown unique advantages such as high micellar stability, programmed cargo delivery and enhanced therapeutic efficiency.

scholarly journals Supramolecular nanoscale drug-delivery system with ordered structure

2019 ◽  
Vol 6 (6) ◽  
pp. 1128-1137 ◽  
Author(s):  
Xin Jin ◽  
Lijuan Zhu ◽  
Bai Xue ◽  
Xinyuan Zhu ◽  
Deyue Yan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Recent Trend ◽  
Building Blocks ◽  
Supramolecular Interactions ◽  
Ordered Structure

Abstract Supramolecular chemistry provides a means to integrate multi-type molecules leading to a dynamic organization. The study of functional nanoscale drug-delivery systems based on supramolecular interactions is a recent trend. Much work has focused on the design of supramolecular building blocks and the engineering of supramolecular integration, with the goal of optimized delivery behavior and enhanced therapeutic effect. This review introduces recent advances in supramolecular designs of nanoscale drug delivery. Supramolecular affinity can act as a main driving force either in the self-assembly of carriers or in the loading of drugs. It is also possible to employ strong recognitions to achieve self-delivery of drugs. Due to dynamic controllable drug-release properties, the supramolecular nanoscale drug-delivery system provides a promising platform for precision medicine.

Fundamental Investigations of Driving Force of a Neutrophile in Liquid Using Concentration Marangoni Effect for Developing Microcapsules in Drug Delivery Systems

2008 ◽  
Author(s):  
Masaaki Tamagawa
Keyword(s):  
Drug Delivery ◽  
Concentration Gradient ◽  
Driving Force ◽  
Drug Delivery Systems ◽  
Marangoni Effect ◽  
Delivery Systems ◽  
Cytokine Concentration

This paper describes the effects of gradient of cytokine concentration on chemotaxis of neutrophile by observing the motion in liquid with adding cytokine concentration. The aim of this investigation is to control of neutrophile motion in liquid by concentration gradient for drug delivery systems.

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