scholarly journals Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab-based therapeutics

2021 ◽  
Author(s):  
Martine Darwish ◽  
Xinxin Gao ◽  
Whitney Shatz ◽  
Hong Li ◽  
May Lin ◽  
...  
Keyword(s):  
Delivery Vehicle ◽  
Cystine Knot ◽  
In Vivo Delivery

Nanolipoprotein particles (NLPs) have been evaluated as an in vivo delivery vehicle for a variety of molecules of therapeutic interest. However, delivery of peptide-like drugs in combination with therapeutic Fabs...

In vivo delivery of bovine viral diahorrea virus, E2 protein using hollow mesoporous silica nanoparticles

Nanoscale ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 6617-6626 ◽  
Author(s):  
D. Mahony ◽  
A. S. Cavallaro ◽  
K. T. Mody ◽  
L. Xiong ◽  
T. J. Mahony ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Viral Protein ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Vehicle ◽  
E2 Protein ◽  
Hollow Mesoporous Silica ◽  
In Vivo Delivery

Immunisation studies in mice show that hollow mesoporous silica nanoparticles act as both a delivery vehicle and adjuvant for the viral protein E2 from bovine viral diahorrea virus.

scholarly journals CRISPR/Cas9 Delivery Potentials in Alzheimer’s Disease Management: A Mini Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 801
Author(s):  
Amira Sayed Hanafy ◽  
Susanne Schoch ◽  
Alf Lamprecht
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Viral Vectors ◽  
Gene Editing ◽  
Gene Sequence ◽  
Viral Vector ◽  
Delivery Vehicle ◽  
Effective Delivery ◽  
In Vivo Delivery

Alzheimer’s disease (AD) is the most common dementia disorder. While genetic mutations account for only 1% of AD cases, sporadic AD resulting from a combination of genetic and risk factors constitutes >90% of the cases. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein (Cas9) is an impactful gene editing tool which identifies a targeted gene sequence, creating a double-stranded break followed by gene inactivation or correction. Although CRISPR/Cas9 can be utilized to irreversibly inactivate or correct faulty genes in AD, a safe and effective delivery system stands as a challenge against the translation of CRISPR therapeutics from bench to bedside. While viral vectors are efficient in CRISPR/Cas9 delivery, they might introduce fatal side effects and immune responses. As non-viral vectors offer a better safety profile, cost-effectiveness and versatility, they can be promising for the in vivo delivery of CRISPR/Cas9 therapeutics. In this minireview, we present an overview of viral and non-viral vector based CRISPR/Cas9 therapeutic strategies that are being evaluated on pre-clinical AD models. Other promising non-viral vectors that can be used for genome editing in AD, such as nanoparticles, nanoclews and microvesicles, are also discussed. Finally, we list the formulation and technical aspects that must be considered in order to develop a successful non-viral CRISPR/Cas9 delivery vehicle.

scholarly journals Adapting decarbonylation chemistry for the development of prodrugs capable of in-vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules

2021 ◽  
Author(s):  
Ladie Kimberly De La Cruz ◽  
Xiaoxiao Yang ◽  
Anna Menshikh ◽  
Maya Brewer ◽  
Wen Lu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Animal Models ◽  
Therapeutic Agent ◽  
Organ Injury ◽  
Signaling Molecule ◽  
In Vivo Delivery ◽  
Co Gas

Carbon monoxide as an endogenous signaling molecule exhibits pharmacological efficacy in various animal models of organ injury. To address the difficulty in using CO gas as a therapeutic agent for...

PEGylated Carbon Nanocapsule: A Universal Reactor and Carrier for In Vivo Delivery of Hydrophobic and Hydrophilic Nanoparticles

2015 ◽  
Vol 8 (1) ◽  
pp. 350-362 ◽  
Author(s):  
Amritha Rammohan ◽  
Gargi Mishra ◽  
Binapani Mahaling ◽  
Lokesh Tayal ◽  
Ahana Mukhopadhyay ◽  
...  
Keyword(s):  
In Vivo Delivery

Bacteria-mediated in vivo delivery of quantum dots into solid tumor

2012 ◽  
Vol 425 (4) ◽  
pp. 769-774 ◽  
Author(s):  
Ying Liu ◽  
Mei Zhou ◽  
Dan Luo ◽  
Lijun Wang ◽  
Yuankai Hong ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Solid Tumor ◽  
In Vivo Delivery
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