scholarly journals Molecular Configuration-mediated Thermo-responsiveness in Oligo(Ethylene Glycol) Derivatives Attached on Gold Nanoparticles

2021 ◽  
Author(s):  
Xiong Kun ◽  
Hideyuki Mitomo ◽  
Xueming Su ◽  
Yier Shi ◽  
Yusuke Yonamine ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Flexible Structures ◽  
Local Environment ◽  
Molecular Configuration ◽  
Biomolecular Systems ◽  
Ethylene Glycol Derivatives

Biomolecular systems actively control their local environment on a sub-nm scale via changes in molecular configuration from their flexible structures and derive emergent functions. Although this functional emergence based on...

Gold nanoparticles decorated with oligo(ethylene glycol) thiols: Surface charges and interactions with proteins in solution

2014 ◽  
Vol 426 ◽  
pp. 31-38 ◽  
Author(s):  
Moritz Schollbach ◽  
Fajun Zhang ◽  
Felix Roosen-Runge ◽  
Maximilian W.A. Skoda ◽  
Robert M.J. Jacobs ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Surface Charges

scholarly journals Ultrasensitive and label free electrochemical immunosensor for detection of ROR1 as an oncofetal biomarker using gold nanoparticles assisted LDH/rGO nanocomposite

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rozita Abolhasan ◽  
Balal Khalilzadeh ◽  
Hadi Yousefi ◽  
Sahar Samemaleki ◽  
Forough Chakari-Khiavi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Flexible Structures ◽  
Modified Electrodes ◽  
Electrochemical Immunosensor ◽  
Lymphocytic Leukemia ◽  
Orphan Receptor ◽  
Detection Sensitivity ◽  
Label Free ◽  
Serum Samples ◽  
Limit Of Quantification

AbstractIn the present article, we developed a highly sensitive label-free electrochemical immunosensor based on NiFe-layered double hydroxides (LDH)/reduced graphene oxide (rGO)/gold nanoparticles modified glassy carbon electrode for the determination of receptor tyrosine kinase-like orphan receptor (ROR)-1. In this electrochemical immunoassay platform, NiFe-LDH/rGO was used due to great electron mobility, high specific surface area and flexible structures, while Au nanoparticles were prepared and coated on the modified electrodes to improve the detection sensitivity and ROR1 antibody immobilizing (ROR1Ab). The modification procedure was approved by using cyclic voltammetry and differential pulse voltammetry based on the response of peak current to the step by step modifications. Under optimum conditions, the experimental results showed that the immunosensor revealed a sensitive response to ROR1 in the range of 0.01–1 pg mL−1, and with a lower limit of quantification of 10 attogram/mL (10 ag mL−1). Furthermore, the designed immunosensor was applied for the analysis of ROR1 in several serum samples of chronic lymphocytic leukemia suffering patients with acceptable results, and it also exhibited good selectivity, reproducibility and stability.

Transdermal delivery of poly(ethylene glycol)-co-oleylamine modified gold nanoparticles: Effect of size and shape

2019 ◽  
Vol 224 ◽  
pp. 22-28 ◽  
Author(s):  
Pa Fan Hsiao ◽  
Hsieh-Chih Tsai ◽  
Sydney Peng ◽  
Adhimoorthy Prasannan ◽  
Ting-Cheng Tang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Transdermal Delivery ◽  
Poly Ethylene Glycol ◽  
Size And Shape ◽  
Poly Ethylene

scholarly journals Development of Bio-Functionalized, Raman Responsive, and Potentially Excretable Gold Nanoclusters

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2181
Author(s):  
Ryan D. Mellor ◽  
Andreas G. Schätzlein ◽  
Ijeoma F. Uchegbu
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Gold Nanoclusters ◽  
Physiological Conditions ◽  
Non Invasive ◽  
In Vivo Detection ◽  
Raman Response ◽  
Octadecyl Amine

Gold nanoparticles (AuNPs) are used experimentally for non-invasive in vivo Raman monitoring because they show a strong absorbance in the phototherapeutic window (650–850 nm), a feature that is accompanied by a particle size in excess of 100 nm. However, these AuNPs cannot be used clinically because they are likely to persist in mammalian systems and resist excretion. In this work, clustered ultrasmall (sub-5 nm) AuNP constructs for in vivo Raman diagnostic monitoring, which are also suitable for mammalian excretion, were synthesized and characterized. Sub-5 nm octadecyl amine (ODA)-coated AuNPs were clustered using a labile dithiol linker: ethylene glycol bis-mercaptoacetate (EGBMA). Upon clustering via a controlled reaction and finally coating with a polymeric amphiphile, a strong absorbance in the phototherapeutic window was demonstrated, thus showing the potential suitability of the construct for non-invasive in vivo detection and monitoring. The clusters, when labelled with a biphenyl-4-thiol (BPT) Raman tag, were shown to elicit a specific Raman response in plasma and to disaggregate back to sub-5 nm particles under physiological conditions (37 °C, 0.8 mM glutathione, pH 7.4). These data demonstrate the potential of these new AuNP clusters (Raman NanoTheranostics—RaNT) for in vivo applications while being in the excretable size window.

Stabilization of L-Asparaginase Modified with Comb-Shaped Poly(ethylene glycol) Derivatives, in vivo and in vitro

1994 ◽  
Vol 5 (4) ◽  
pp. 283-286 ◽  
Author(s):  
Yoh Kodera ◽  
Taichi Sekine ◽  
Tohru Yasukohchi ◽  
Yoshihiro Kiriu ◽  
Misao Hiroto ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ethylene Glycol Derivatives
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