scholarly journals Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

2022 ◽  
Author(s):  
Fernanda Caldas Cardoso ◽  
Matthieu Schmit ◽  
Michael Kuiper ◽  
Richard Lewis ◽  
Kellie Tuck ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Ion Channels ◽  
Calcium Ion ◽  
Tricyclic Antidepressants ◽  
Theoretical Justification ◽  
Off Label ◽  
Calcium Ion Channels

A number of tricyclic antidepressants (TCAs) are commonly prescribed off-label for the treatment of neuropathic pain. The blockade of neuronal calcium ion channels is often invoked to partially explain the...

Su1955 Characterization of Calcium Ion Channels in DRG Neurons Regulated by BDNF and Colitis

2016 ◽  
Vol 150 (4) ◽  
pp. S598
Author(s):  
Shanwei Shen ◽  
John R. Grider ◽  
Hamid I. Akbarali ◽  
Liya Qiao
Keyword(s):  
Ion Channels ◽  
Calcium Ion ◽  
Drg Neurons ◽  
Calcium Ion Channels

scholarly journals The inhibition of neuronal calcium ion channels by trace levels of yttrium released from carbon nanotubes

Biomaterials ◽  
2009 ◽  
Vol 30 (31) ◽  
pp. 6351-6357 ◽  
Author(s):  
Lorin M. Jakubek ◽  
Spiro Marangoudakis ◽  
Jesica Raingo ◽  
Xinyuan Liu ◽  
Diane Lipscombe ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Ion Channels ◽  
Calcium Ion ◽  
Calcium Ion Channels

scholarly journals Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection

2018 ◽  
Vol 19 (9) ◽  
pp. 2465 ◽  
Author(s):  
John D’Elia ◽  
Larry Weinrauch
Keyword(s):  
Vitamin D ◽  
Ion Channels ◽  
Inflammatory Response ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Calcium Ion ◽  
Defense Mechanisms ◽  
Channel Blocker ◽  
Inadequate Response ◽  
Calcium Ion Channels

Immunosuppression may occur for a number of reasons related to an individual’s frailty, debility, disease or from therapeutic iatrogenic intervention or misadventure. A large percentage of morbidity and mortality in immunodeficient populations is related to an inadequate response to infectious agents with slow response to antibiotics, enhancements of antibiotic resistance in populations, and markedly increased prevalence of acute inflammatory response, septic and infection related death. Given known relationships between intracellular calcium ion concentrations and cytotoxicity and cellular death, we looked at currently available data linking blockade of calcium ion channels and potential decrease in expression of sepsis among immunosuppressed patients. Notable are relationships between calcium, calcium channel, vitamin D mechanisms associated with sepsis and demonstration of antibiotic-resistant pathogens that may utilize channels sensitive to calcium channel blocker. We note that sepsis shock syndrome represents loss of regulation of inflammatory response to infection and that vitamin D, parathyroid hormone, fibroblast growth factor, and klotho interact with sepsis defense mechanisms in which movement of calcium and phosphorus are part of the process. Given these observations we consider that further investigation of the effect of relatively inexpensive calcium channel blockade agents of infections in immunosuppressed populations might be worthwhile.

scholarly journals Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ashish Thapliyal ◽  
Rashmi Verma ◽  
Navin Kumar
Keyword(s):  
Ion Channels ◽  
Cell Growth ◽  
G Proteins ◽  
Cell Lines ◽  
Calcium Ion ◽  
Small Gtpase ◽  
Calcium Ion Channels ◽  
Hormonal Release ◽  
Small G Proteins

Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GTPases have been reported to prevent the aberrant cell growth and induce apoptosis in cell lines. Present review focuses on role of these two monomeric GTPases and summarizes their role in pathophysiological processes.

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