4-Amino-1,8-Naphthalimide-Ferrocene Conjugates as Potential Multi-targeted Anticancer and Fluorescent Cellular Imaging Agents

2021 ◽  
Author(s):  
Alex Johnson ◽  
A. Joseph Buhagiar ◽  
David C Magri
Keyword(s):  
Logic Gates ◽  
Cellular Imaging ◽  
Imaging Agents

Herein we present eight ferrocenyl 4-amino-1,8-naphthalimides. Designed as fluorescent logic gates for acidity and oxidisability, the molecules have been repurposed as antiproliferation and cellular imaging agents. The compounds were studied...

scholarly journals Ru(ii)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents

Nanoscale ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 563-574 ◽  
Author(s):  
Miguel Martínez-Calvo ◽  
Kim N. Orange ◽  
Robert B. P. Elmes ◽  
Bjørn la Cour Poulsen ◽  
D. Clive Williams ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cellular Imaging ◽  
Supramolecular Structures ◽  
Imaging Agents ◽  
Dna Targeting ◽  
Functionalized Gold Nanoparticles ◽  
Average Size

The development of 15 nm (average size) Ru(ii) functionalized gold nanoparticles 1–3·AuNP is described.

Fluorescent Rhenium-Naphthalimide Conjugates as Cellular Imaging Agents

2014 ◽  
Vol 53 (7) ◽  
pp. 3788-3797 ◽  
Author(s):  
Emily E. Langdon-Jones ◽  
Nadine O. Symonds ◽  
Sara E. Yates ◽  
Anthony J. Hayes ◽  
David Lloyd ◽  
...  
Keyword(s):  
Cellular Imaging ◽  
Imaging Agents

scholarly journals Simple conjugated polymer nanoparticles as biological labels

2009 ◽  
Vol 465 (2109) ◽  
pp. 2751-2759 ◽  
Author(s):  
Mark Green ◽  
Philip Howes ◽  
Catherine Berry ◽  
Orestis Argyros ◽  
Maya Thanou
Keyword(s):  
Optical Imaging ◽  
Conjugated Polymer ◽  
Clinical Applications ◽  
Cellular Imaging ◽  
Organic Dye ◽  
Polymer Nanoparticles ◽  
Imaging Agents ◽  
Conjugated Polymer Nanoparticles

The use of nanoparticles in biology, especially in cellular imaging, is extremely promising and offers numerous advantages over existing organic dye systems. There are, however, constraints that need to be addressed before the use of such materials in mainstream clinical applications can be realized. One of the main concerns is the use of metal-containing particles that are potentially toxic or interfere with other diagnostic processes. Here, we present the use of simple conjugated polymer nanoparticles as alternative photostable cellular optical imaging agents.

scholarly journals 2089 Detecting inflammation in atherosclerosis using protein cage nanoparticles as cellular imaging agents

2008 ◽  
Vol 10 (S1) ◽  
Author(s):  
Masahiro Terashima ◽  
Masaki Uchida ◽  
Hisanori Kosuge ◽  
Shay Keren ◽  
Philip S Tsao ◽  
...  
Keyword(s):  
Cellular Imaging ◽  
Imaging Agents ◽  
Protein Cage

scholarly journals Photophysical and Biological Properties of Iridium Tetrazolato Complexes Functionalised with Fatty Acid Chains

Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 23
Author(s):  
Chiara Caporale ◽  
Anna Maria Ranieri ◽  
Silvano Paternoster ◽  
Christie A. Bader ◽  
Marco Falasca ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Photophysical Properties ◽  
Aqueous Media ◽  
Potential Effect ◽  
Biological Properties ◽  
Cellular Imaging ◽  
Quantum Yields ◽  
Imaging Agents ◽  
Yellow Emission ◽  
Low Cytotoxicity

Five cyclometalated Ir(III) tetrazolato complexes functionalised with fatty acid chains (octanoic, palmitic, stearic, palmitoleic, and oleic) have been synthesised. The fatty acids were chosen to evaluate the potential effect of the length and degree of unsaturation on the biological properties of the complexes for use as cellular imaging agents. The complexes were analysed in both organic and aqueous media to determine if the presence and nature of the fatty acid chains had a significant effect on their photophysical properties. The complexes display green–yellow emission in dichloromethane solutions with relatively long excited state decays, within the range 360–393 ns, and quantum yields between 5.4% and 6.7% (from degassed solutions). Temperature-dependent photophysical studies suggest that the emitting excited states of the complexes might be quenched by the thermal population of dark states. In water, the quantum yields drop within the range of 0.5%–2.4%, and the photophysical measurements are influenced by the variable degrees of aggregation. In general, the entire series displayed low cytotoxicity and relatively high photostability, which are favourable attributes in the design of cellular imaging agents. Images of live HeLa cells were obtained for all the complexes, but those functionalised with palmitic and stearic acids had limitations due the lower solubility conferred by the saturated aliphatic chains. The complexes were mainly detected within the endoplasmic reticulum.

scholarly journals Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents

2013 ◽  
Vol 42 (4) ◽  
pp. 1601 ◽  
Author(s):  
Swagata Banerjee ◽  
Emma B. Veale ◽  
Caroline M. Phelan ◽  
Samantha A. Murphy ◽  
Gillian M. Tocci ◽  
...  
Keyword(s):  
Cellular Imaging ◽  
Imaging Agents ◽  
Dna Targeting ◽  
Recent Advances

scholarly journals Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

2012 ◽  
Vol 48 (20) ◽  
pp. 2588 ◽  
Author(s):  
Robert B. P. Elmes ◽  
Marialuisa Erby ◽  
Sandra A. Bright ◽  
D. Clive Williams ◽  
Thorfinnur Gunnlaugsson
Keyword(s):  
Cellular Imaging ◽  
Imaging Agents ◽  
Biological Investigation

scholarly journals Luminescent Ruthenium(II) Polypyridyl Functionalized Gold Nanoparticles; Their DNA Binding Abilities and Application As Cellular Imaging Agents

2011 ◽  
Vol 133 (40) ◽  
pp. 15862-15865 ◽  
Author(s):  
Robert B. P. Elmes ◽  
Kim N. Orange ◽  
Suzanne M. Cloonan ◽  
D. Clive Williams ◽  
Thorfinnur Gunnlaugsson
Keyword(s):  
Gold Nanoparticles ◽  
Dna Binding ◽  
Cellular Imaging ◽  
Imaging Agents ◽  
Functionalized Gold Nanoparticles

A gold nanocluster-based fluorescent probe for simultaneous pH and temperature sensing and its application to cellular imaging and logic gates

Nanoscale ◽  
2016 ◽  
Vol 8 (21) ◽  
pp. 11210-11216 ◽  
Author(s):  
Yun-Tse Wu ◽  
Chandirasekar Shanmugam ◽  
Wei-Bin Tseng ◽  
Ming-Mu Hiseh ◽  
Wei-Lung Tseng
Keyword(s):  
Fluorescent Probe ◽  
Logic Gates ◽  
Cellular Imaging ◽  
Temperature Sensing ◽  
Gold Nanocluster
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