Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators

2021 ◽  
Author(s):  
Kleinberg X. Fernandez ◽  
Conrad Fischer ◽  
Jennie Vu ◽  
Mahmoud Gheblawi ◽  
Wang Wang ◽  
...  
Keyword(s):  
Hypotensive Effect ◽  
Apelin Receptor

Cyclohexylalanine- and homoarginine-substituted apelin analogues are demonstrated to be metabolically stable APJR agonistic peptides with hypotensive effect.

scholarly journals The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment

2018 ◽  
Vol 131 ◽  
pp. 7-16 ◽  
Author(s):  
Élie Besserer-Offroy ◽  
Patrick Bérubé ◽  
Jérôme Côté ◽  
Alexandre Murza ◽  
Jean-Michel Longpré ◽  
...  
Keyword(s):  
Hypotensive Effect ◽  
Apelin Receptor

THE FALL OF BLOOD PRESSURE FOLLOWING INDUCTION OF DECIDUOMATA IN STEROID HYPERTENSIVE RATS RECEIVING PROGESTERONE

1968 ◽  
Vol 59 (2) ◽  
pp. 227-234 ◽  
Author(s):  
H. C. Moore ◽  
I. Cserhati ◽  
F. P. Biliczki
Keyword(s):  
Blood Pressure ◽  
Hypotensive Effect ◽  
Hypertensive Rats ◽  
Pregnant Rats ◽  
Hypertensive Rat ◽  
Equivalent Time ◽  
Metrial Gland ◽  
Blood Pressure Responses ◽  
A Minor ◽  
Maternal Decidua

ABSTRACT Experimental deciduomata and progesterone together lower the blood pressure in the steroid hypertensive rat from the 5th to 10th day of decidual growth i. e. from the 10th to 15th day of pseudopregnancy. This would suggest that the fall of blood pressure at an equivalent time of gestation in hypertensive pregnant rats could be due to the maternal decidua under the influence of progesterone. It is further considered that the metrial gland of the deciduoma is more likely to be responsible for the hypotensive effect and by comparison that the metrial gland is implicated in the hypotensive effect of pregnancy. Progesterone alone also exerts a minor hypotensive effect in those animals in which a nephrectomy forms part of the hypertension regimen and indicates one way in which a maternal renal factor could influence blood pressure responses in hypertensive pregnant rats.

Hypotensive effect of cataract phacoemulsification in patients with variousstages of open angle glaucoma

2020 ◽  
pp. 93-94
Author(s):  
A.R. Vinogradov ◽  
◽  
B.G. Dzhashi ◽  
M.V. Morgatskaia ◽  
Y.S. Serkov ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Hypotensive Effect ◽  
Open Angle

Цель. Оценить гипотензивный эффект факоэмульсификации катаракты (ФЭК) у пациентов с ранее не оперированной открытоугольной глаукомой различных стадий. Материал и методы. Проведен анализ результатов ФЭК у 136 пациентов (136 глаз). Средний возраст пациентов 72±8,9 лет. ФЭК с имплантацией гибкой ИОЛ выполнялась по стандартной технологии тоннельным разрезом 2,0 мм на факоэмульсификаторах Infinity и Centurion Vision System.Пациенты были распределены на 3 группы: 1-ягруппа – I стадия, 2-я группа – II стадия, 3-я группа – III стадия глаукомы. Срок наблюдения 1 год. Результаты. В 1-й группе отмечалось снижение ВГД на срок наблюдения 1 год на 10% от исходного уровня: с 18,5±4,3 до 16,7±2,4 мм рт.ст. Во 2-й группе пациентов выявлено снижение ВГД с 18,4±4,5 до17,4±3,5 мм рт.ст. (на 7,6%). В 3-й группе отмечалось снижение ВГД с 19,8±4,1 до 18,3±2,3 мм рт.ст.(на 7,5%). Выводы. Выявлено достоверное снижение ВГД после выполнения ФЭК на глазах с начальной глаукомой. У пациентов с развитой и далекозашедшей стадией глаукомы гипотензивный эффект достоверно ниже.

Temporary “liquid” Implant for Congenital Glaucoma (long-term results)

2020 ◽  
pp. 49-65
Author(s):  
N Bobrova ◽  
N Trofimova
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Hypotensive Effect ◽  
Congenital Glaucoma ◽  
Long Term Results ◽  
General Will ◽  
Visual Functions ◽  
Advanced Stages ◽  
Intraocular Fluid

The aim of the work was to analyze the long-term results of using a temporary “liquid” implant in the surgery of congenital glaucoma in children. The basis of the developed method of filtrative antiglaucomatous surgery (Patent of Ukraine No. 45099 of 2009) – viscosinusotrabeculotomy – has been set the task of reducing the risk of developing intra- and postoperative complications, reducing the scarring rate and maintaining the newly created ways of the intraocular fluid outflow, which in general will increase the effectiveness of surgical treatment of congenital glaucoma in children. 54 children (91 eyes) with simple congenital glaucoma at the age of 1 to 36 months were operated on average (8.7 ± 8.2) months. The persistent and long-lasting hypotensive effect achieved due to viscosinusotrabeculotomy in children with developed and far-advanced stages of congenital glaucoma stops the processes of stretching of the membranes of the eye and stabilizes their size, which in general allows preserving and visual functions improving, in infancy – creating conditions for their formation.

Hypotensive effect of dopamine

2005 ◽  
Vol 60 (3) ◽  
pp. 253-257
Author(s):  
Juan Carlos PRIETO ◽  
Mónica QUEVEDO ◽  
Hugo F. MIRANDA ◽  
Gianni PINARDI
Keyword(s):  
Hypotensive Effect

scholarly journals ACE Inhibitory and Antihypertensive Activities of Wine Lees and Relationship among Bioactivity and Phenolic Profile

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 679
Author(s):  
Raúl López-Fernández-Sobrino ◽  
Jorge R. Soliz-Rueda ◽  
Maria Margalef ◽  
Anna Arola-Arnal ◽  
Manuel Suárez ◽  
...  
Keyword(s):  
Hypotensive Effect ◽  
Wine Industry ◽  
Antihypertensive Activity ◽  
Spontaneously Hypertensive ◽  
Lowering Effect ◽  
Before And After ◽  
Phenolic Profiles ◽  
Wistar Kyoto ◽  
Grape Varieties ◽  
The Relationship

Wine lees (WL) are by-products generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar–Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to commercial use within the wine industry.

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