scholarly journals Water solubilization of paclitaxel using polypeptides for cancer therapy

2021 ◽  
Author(s):  
Riku Kawasaki ◽  
Shogo Kawamura ◽  
Shodai Hino ◽  
Keita Yamana ◽  
Atsushi Ikeda
Keyword(s):  
Drug Discovery ◽  
Cancer Therapy ◽  
High Speed ◽  
Current Method ◽  
Hydrophobic Compounds ◽  
Vibration Milling ◽  
Water Solubilization

To address problems in drug discovery, we developed approaches to solubilize hydrophobic compounds using polypeptides including poly-L-lysine (PLL) via high-speed vibration milling. The current method can be used to prepare...

scholarly journals High-speed vibration-milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units

2017 ◽  
Vol 13 ◽  
pp. 1957-1962 ◽  
Author(s):  
Marco Leonardi ◽  
Mercedes Villacampa ◽  
J Carlos Menéndez
Keyword(s):  
Drug Discovery ◽  
Double Bond ◽  
Zirconium Oxide ◽  
High Speed ◽  
Chemical Space ◽  
Dicarbonyl Compounds ◽  
Cross Metathesis ◽  
Aryl Ketones ◽  
Vibration Milling

The pseudo-five-component reaction between β-dicarbonyl compounds (2 molecules), diamines and α-iodoketones (2 molecules), prepared in situ from aryl ketones, was performed efficiently under mechanochemical conditions involving high-speed vibration milling with a single zirconium oxide ball. This reaction afforded symmetrical frameworks containing two pyrrole or fused pyrrole units joined by a spacer, which are of interest in the exploration of chemical space for drug discovery purposes. The method was also extended to the synthesis of one compound containing three identical pyrrole fragments via a pseudo-seven-component reaction. Access to compounds having a double bond in their spacer chain was achieved by a different approach involving the homodimerization of 1-allyl- or 1-homoallylpyrroles by application of cross-metathesis chemistry.

The applications of next-generation sequencing (NGS) in drug development for cancer therapy

2020 ◽  
Vol 16 ◽  
Author(s):  
Pelin Telkoparan-Akillilar ◽  
Dilek Cevik
Keyword(s):  
Next Generation Sequencing ◽  
Drug Discovery ◽  
Cancer Therapy ◽  
Target Identification ◽  
Rapid Development ◽  
Next Generation ◽  
Biomedical Sciences ◽  
Dna And Rna ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Background: Numerous sequencing techniques have been progressed since the 1960s with the rapid development of molecular biology studies focusing on DNA and RNA. Methods: a great number of articles, book chapters, websites are reviewed, and the studies covering NGS history, technology and applications to cancer therapy are included in the present article. Results: High throughput next-generation sequencing (NGS) technologies offer many advantages over classical Sanger sequencing with decreasing cost per base and increasing sequencing efficiency. NGS technologies are combined with bioinformatics software to sequence genomes to be used in diagnostics, transcriptomics, epidemiologic and clinical trials in biomedical sciences. The NGS technology has also been successfully used in drug discovery for the treatment of different cancer types. Conclusion: This review focuses on current and potential applications of NGS in various stages of drug discovery process, from target identification through to personalized medicine.

Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions

2014 ◽  
Vol 1 (5) ◽  
pp. 458-463 ◽  
Author(s):  
Verónica Estévez ◽  
Mercedes Villacampa ◽  
J. Carlos Menéndez
Keyword(s):  
Multicomponent Reaction ◽  
Acid Treatment ◽  
High Speed ◽  
Vibration Milling

A Hantzsch-type multicomponent reaction under high-speed vibration milling conditions followed by acid treatment afforded atorvastatin lactone in 38% overall yield.

ChemInform Abstract: Solvent-Free Synthesis of 2-Aminothiophene-3-carbonitrile Derivatives Using High-Speed Vibration Milling.

ChemInform ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. no-no
Author(s):  
Fang Xu ◽  
Yujin Li ◽  
Fengshuang Xu ◽  
Qing Ye ◽  
Liang Han ◽  
...  
Keyword(s):  
High Speed ◽  
Solvent Free ◽  
Solvent Free Synthesis ◽  
Vibration Milling

scholarly journals Amphiphilic γ-Cyclodextrin–Fullerene Complexes with Photodynamic Activity

2021 ◽  
Author(s):  
Koji Miki ◽  
Zi Dan Zhang ◽  
Kaho Kaneko ◽  
Yui Kakiuchi ◽  
Kentaro Kojima ◽  
...  
Keyword(s):  
High Speed ◽  
Fullerene Complex ◽  
Photodynamic Activity ◽  
Fullerene Complexes ◽  
Vibration Milling

Amphiphilic γ-cyclodextrin–fullerene 2:1 complexes (CLFCH complexes) were prepared by high-speed vibration milling of lipophilic tail-grafted γ-cyclodextrin (γ-CD), hydrophilic tail-grafted γ-CD and fullerene C60. The transamidation of γ-CD–fullerene complex having two...

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