scholarly journals Antibacterial peptidomimetic and characterization of its efficacy as an antibacterial and biocompatible coating for bioceramic-based bone substitutes

2021 ◽  
Author(s):  
Sudip Chakraborty ◽  
Rajesh Kuppusamy ◽  
Iman Roohani ◽  
William R. Walsh ◽  
Mark D. P. Willcox ◽  
...  

Novel strategies to combat orthopedic device related infections are the need of the hour. We have synthesized an antibacterial peptidomimetic and characterized its suitability as a non-covalent coating material for bioceramic hydroxyapatite discs.

2007 ◽  
Vol 330-332 ◽  
pp. 415-418 ◽  
Author(s):  
Xiao Liang Wang ◽  
Xu Dong Li ◽  
Xiao Min Wang ◽  
Jian Lu ◽  
Hui Chuan Zhao ◽  
...  

Collagen (Col) and chitosan (Chi) are both natural polymers and have received extensive investigation in recent years in the field of tissue engineering, but there are few reports on the introduction of hydroxyapatite (HA) into the Col-Ch system. In this study, based on the miscibility of these two polymers under proper condition, hydroxyapatite (HA) was synthesis in the Col-Chi system by in-situ co-precipitate method to give rise to a novel nanocomposite. The structural characterization of such Col-Ch-HA nano-materials was carried out by using FT-IR, XRD, SEM and TGA analyses with main components and Col-Chi samples used for comparison. It was found that there exist interactions between Col and Chi molecules. The nucleation and growth of inorganic phase occurs in the Col-Chi system and final products are uniform dispersion of nano-sized HA in the Col-Chi network without obvious phase separation. This novel nanocomposite would be a promising material for bone tissue engineering.


2016 ◽  
Vol 54 (15) ◽  
pp. 2386-2393 ◽  
Author(s):  
Leire Pérez-Ibarbia ◽  
Tobias C. Majdanski ◽  
Stephanie Schubert ◽  
Norbert Windhab ◽  
Ulrich S. Schubert

2013 ◽  
Vol 541 ◽  
pp. 97-113 ◽  
Author(s):  
Rossella Bedini ◽  
Deborah Meleo ◽  
Raffaella Pecci

After a short introduction to bone substitute biomaterials and X-ray microtomography, this article describes a research work carried out for in-vitro characterization of bone substitute biomaterials as well as for in-vivo investigation of human bone grafted with biomaterials. Three different bone substitute biomaterials have been analyzed in-vitro by means of 3D microtomographic technique, while human bone samples grafted with bone substitute biomaterials are investigated by 3D microtomography and histological techniques. 3D images of bone substitutes and human bone samples with biomaterials have been obtained, together with morphometric parameters, by microtomography . 2D histological images have also been obtained by traditional technique only for human bone samples with biomaterials. Compared to traditional histological analysis, 3D microtomography shows better results for investigating bone tissue and bone substitute biomaterial, and in a short time. Nevertheless, histological analysis remains the best technique for the observation of soft tissue and blood vessels.


2018 ◽  
Vol 72 (3) ◽  
pp. 139-147 ◽  
Author(s):  
Aleksandar Maslarevic ◽  
Gordana Bakic ◽  
Milos Djukic ◽  
Bratislav Rajicic ◽  
Vesna Maksimovic

Parts of industrial machines and structures are often exposed to the action of aggressive environments, which in a short period of time can provoke the loss of their integrity. It is well known that for extending the service life against erosion and corrosion, protection of the exposed structure zone by coating is frequently used. Various application methods of protective coatings are applied, and the most common are welding and thermal spraying processes. The aim of this study was characterization of coatings made of stainless steel 316L, widely used in chemical and petrochemical industries. The coating was applied on a structural steel S235JR by plasma transferred arc using powder as a filler material. Due to a number of advantages, the plasma transferred arc (PTA) surfacing process has found significant usages in the field of surface protection. This paper presents results of hardness measurements in characteristic zones of the coating and the base material, as well as microstructural characterization of coatings using optical and scanning electron microscopy. Results of EDS analysis of the coating and hardness measurements indicated that a relatively high dilution (26.1 %) of the base material (BM) and the filler material (FM) occurred in a very narrow zone above the fusion line, and thus did not significantly affect the chemical composition of the rest of the coating. Also, erosion resistance tests of coatings were performed by changing the basic functional parameters that is the impact angle and the speed of erodent particles. It was observed that the erosion resistance of the coating material decreases approximately linearly with the increase of the particle speed. Also, with the increase of the impact angle of the erodent (up to 45 ?), the mass loss of the coating material is increased.


2019 ◽  
Vol 27 (4) ◽  
pp. 774-783 ◽  
Author(s):  
Johanna Santamaría Vanegas ◽  
Gladys Rozo Torres ◽  
Briyith Barreto Campos
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