scholarly journals Eugenol micro-emulsion reinforced with silver nanocomposite electrospun mats for wound dressing strategies

2021 ◽  
Author(s):  
Lakshimipriya Sethuram ◽  
Thomas John ◽  
Amitava Mukherjee ◽  
Natarajan Chandrasekaran
Keyword(s):  
Mechanical Property ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Tissue Scaffolds ◽  
Wound Management ◽  
Complex Process ◽  
Excellent Mechanical Property ◽  
Micro Emulsion ◽  
Silver Nanocomposite ◽  
Good Biocompatibility

Wound management is a complex process that involves application of tissue scaffolds/nanocomposites for wound healing treatment. An ideal wound dressing possesses excellent mechanical property, good biocompatibility and effective antibacterial activity....

scholarly journals Emulsion Electrospun Fiber Mats of PCL/PVA/Chitosan and Eugenol for Wound Dressing Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Cláudia Mouro ◽  
Manuel Simões ◽  
Isabel C. Gouveia
Keyword(s):  
Contact Angle ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Electrospun Fiber ◽  
Total Porosity ◽  
Dermal Fibroblasts ◽  
Wound Management ◽  
Water Contact ◽  
Fiber Mats

In recent years, the damaging effects of antimicrobial resistance relating to wound management and infections have driven the ongoing development of composite wound dressing mats containing natural compounds, such as plant extracts and their derivatives. The present research reports the fabrication of novel electrospun Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)/Chitosan (CS) fiber mats loaded with Eugenol (EUG), an essential oil, known for its therapeutic properties. The electrospun fiber mats were prepared via electrospinning from either water-in-oil (W/O) or oil-in-water (O/W) emulsions and characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), total porosity measurements, and water contact angle. The in vitro EUG release profile and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were also evaluated. The obtained results proved that the EUG was loaded efficiently into electrospun PCL/PVA/CS fiber mats and the two W/O and O/W emulsions prepared from the PCL/PVA/CS (7 : 3 : 1) and PCL/PVA/CS (3 : 7 : 1) revealed porosity within the ideal range of 60–90%, even when EUG was loaded. The measured contact angle values showed that the O/W emulsion exhibited a more hydrophilic character and the wettability noticeably decreased after adding EUG in both emulsion blends. Furthermore, the electrospun PCL/PVA/CS fiber mats demonstrated a rapid release of EUG during the first 8 hours, which enhanced gradually afterward (up to 120 hours). Moreover, an efficient antibacterial activity against S. aureus (inhibition ratios of 92.43% and 83.08%) and P. aeruginosa (inhibition ratios of 94.68% and 87.85%) was displayed and the in vitro cytotoxic assay demonstrated that the normal human dermal fibroblasts (NHDF) remained viable for at least 7 days, after direct contact with the produced electrospun fiber mats. Therefore, such findings support the biocompatibility and suitability of using these EUG-loaded electrospun PCL/PVA/CS fiber mats as a new innovative wound dressing material with potential for preventing and treating microbial wound infections.

THE FABRICATION AND CHARACTERIZATION OF 3D POROUS SERICIN/FIBROIN BLENDED SCAFFOLDS

2011 ◽  
Vol 23 (01) ◽  
pp. 1-12 ◽  
Author(s):  
Jian-Wei Rao ◽  
Liang-Qi Ouyang ◽  
Xian-lei Jia ◽  
Da-Ping Quan ◽  
Yang-Bin Xu
Keyword(s):  
Mechanical Property ◽  
Mtt Assay ◽  
Three Dimensional ◽  
Particle Sizes ◽  
X Ray Diffraction ◽  
Salt Leaching ◽  
Excellent Mechanical Property ◽  
Good Biocompatibility ◽  
First Time

Objective: To explore how to fabricate the three-dimensional (3D) porous sericin/fibroin blended scaffolds for the first time. Methods: The 3D porous sericin/fibroin blended scaffolds were fabricated by salt leaching method, its morphology was observed by scanning electron microscopy (SEM), its structure was characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), its mechanical property was characterized by resistance to mechanical compression and rebound/compressed ratio, protease XIV was used to tested its degradation in vitro, MTT assay was used to quantitatively analyze the PC12 cells' viability co cultured with its extraction fluid. Results: Varying the ratios of sericin/fibroin and the particle sizes of granular NaCl used in the process, leads to the control of morphological and functional properties of the scaffolds. The 3D porous sericin/fibroin blended scaffolds had homogeneous and interconnected pores which controlled by the particle sizes of granular NaCl , shared similar crystal structure of β-sheet with the natural silk, importantly, and had excellent mechanical properties. MTT assay results showed that the sericin/fibroin blended scaffolds also had good biocompatibility. Conclusion: The 3D porous sericin/fibroin blended scaffolds provide useful properties as control of pore size, degradability, excellent mechanical property, and good biocompatibility, which substantiated the potential of it for use in tissue engineering applications.

scholarly journals An Injectable Chitosan-Based Self-Healable Hydrogel System as An Antibacterial Wound Dressing

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 5956
Author(s):  
Xiaoyu Wang ◽  
Rijian Song ◽  
Melissa Johnson ◽  
Sigen A ◽  
Zhonglei He ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Wound Dressing ◽  
Cost Effective ◽  
Hek 293 ◽  
293 Cells ◽  
Good Biocompatibility ◽  
Crosslinking Agents ◽  
Hydrogel System

Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, and genipin. Therefore, we developed a biocompatible yet cost-effective chitosan-based hydrogel system as a candidate biomaterial to prevent infection during wound healing. The hydrogel was fabricated by crosslinking chitosan with dialdehyde chitosan (CTS–CHO) via dynamic Schiff-base reactions, resulting in a self-healable and injectable system. The rheological properties, degradation profile, and self-healable properties of the chitosan-based hydrogel were evaluated. The excellent antibacterial activity of the hydrogel was validated by a spread plate experiment. The use of Live/Dead assay on HEK 293 cells showed that the hydrogel exhibited excellent biocompatibility. The results demonstrate that the newly designed chitosan-based hydrogel is an excellent antibacterial wound dressing candidate with good biocompatibility.

scholarly journals Curcumin-loaded polyvinyl butyral film with antibacterial activity

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 673-681
Author(s):  
Yanchao Qiao ◽  
Lijie Duan
Keyword(s):  
Mechanical Property ◽  
Thermal Stability ◽  
Antibacterial Activity ◽  
Polyvinyl Butyral ◽  
Counting Method ◽  
E Coli ◽  
Antibacterial Materials ◽  
Good Antibacterial Activity ◽  
Colony Counting ◽  
Widespread Interest

AbstractAntibacterial materials have found widespread interest in different fields nowadays. In this study, curcumin (Cur) was incorporated into the polyvinyl butyral (PVB) matrix by dissolving in ethanol for improving the functional properties of a pure PVB film. We found that Cur was uniformly dispersed in the PVB matrix, which showed good compatibility. Moreover, the incorporation of Cur could also improve thermal stability, hydrophilicity, and mechanical property. The UV-vis spectra of the PVB–Cur film demonstrated that the film could block ultraviolet radiation. Subsequently, the antibacterial activity of the PVB–Cur film was measured by the colony-counting method against S. aureus and E. coli. The results showed that the PVB–Cur film exhibited good antibacterial activity. Therefore, the PVB–Cur film was considered as a promising material for food and medical packaging applications.

Engineering flexible carbon nanofibers concatenated MOFs-derived hollow octahedral CoFe2O4 as anode materials for enhanced lithium storage

2021 ◽  
Author(s):  
Fangfang Xue ◽  
Yangyang Li ◽  
Chen Liu ◽  
Zhigang Zhang ◽  
Jun Lin ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Anode Materials ◽  
Electrode Materials ◽  
Electronic Devices ◽  
High Capacity ◽  
Lithium Ion ◽  
Lithium Storage ◽  
Excellent Mechanical Property ◽  
Wearable Electronic ◽  
Wearable Electronic Devices

Constructing suitable electrode materials with high capacity and excellent mechanical property is indispensable for flexible lithium-ion batteries (LIBs) to satisfy the growing flexible and wearable electronic devices. Herein, a necklace-like...

Injectable keratin hydrogels as hemostatic and wound dressing materials

2021 ◽  
Author(s):  
Ao Tang ◽  
Ying Li ◽  
Yiqian Yao ◽  
Xuexia Yang ◽  
Zhangjun Cao ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Good Biocompatibility ◽  
Dressing Materials ◽  
Administration Procedure ◽  
Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

Self-healing poly(siloxane-urethane) elastomers with remoldability, shape memory and biocompatibility

2016 ◽  
Vol 7 (47) ◽  
pp. 7278-7286 ◽  
Author(s):  
Jian Zhao ◽  
Rui Xu ◽  
Gaoxing Luo ◽  
Jun Wu ◽  
Hesheng Xia
Keyword(s):  
Mechanical Property ◽  
Shape Memory ◽  
Microphase Separation ◽  
Diels Alder ◽  
Good Mechanical Property ◽  
Self Healing ◽  
Healing Efficiency ◽  
Good Biocompatibility

The poly(siloxane-urethane) elastomers with microphase separation structure and Diels–Alder bonds show high healing efficiency, good mechanical property and good biocompatibility.

Electrospun Sandwich-Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity

2017 ◽  
Vol 303 (2) ◽  
pp. 1700270 ◽  
Author(s):  
Jinzhen Li ◽  
Yang Hu ◽  
Ting He ◽  
Mengwen Huang ◽  
Xiangchao Zhang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
Sandwich Structure ◽  
Composite Membranes
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