scholarly journals Assessment of Dihydropyrimidinone based Nanocomposites as Multifunctional Anti-cancer Drug

2021 ◽  
Author(s):  
Thangamani Suppan ◽  
Hema Priya Mahendran ◽  
Rama Ranjan Bhattacharjee ◽  
Sankarganesh Jeyaraj ◽  
Kallol Mohanta
Keyword(s):  
Quantum Dot ◽  
Cancer Drug ◽  
The Novel ◽  
Carbon Quantum Dot ◽  
Anti Cancer ◽  
Tumor Inhibitor

Dihydropyrimidinones, a Biginelli compound, have been found to be a tumor inhibitor in the last decade. The novel carbon quantum dot- dihydropyrimidinone (CQD-DHPM) nanocomposites have been prepared by a simple...

Facile Synthetic Protocols for the preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-Cancer Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Rama Mohana Reddy Jaggavarapu ◽  
Venkatanarayana Muvvala ◽  
Ghojala Venkatareddy ◽  
Ravi Kumar Cheedarala
Keyword(s):  
Quality Control ◽  
Spectral Analysis ◽  
1H Nmr ◽  
Structure Elucidation ◽  
Research Work ◽  
Synthetic Methods ◽  
Cancer Drug ◽  
The Novel ◽  
Anti Cancer ◽  
Pemetrexed Disodium

: A facile synthetic protocols were employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for the quality control.

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT

2012 ◽  
Vol 403 (1) ◽  
pp. 309-321 ◽  
Author(s):  
Ján Stariat ◽  
Vít Šesták ◽  
Kateřina Vávrová ◽  
Milan Nobilis ◽  
Zuzana Kollárová ◽  
...  
Keyword(s):  
Phase I ◽  
Cancer Drug ◽  
The Novel ◽  
Anti Cancer

Preparation and Characterization of Novel Anti-cancer drug (s) loaded Co-crystals

2021 ◽  
Vol 23 (09) ◽  
pp. 1006-1019
Author(s):  
Manju Kharb ◽  
◽  
Pawan Jalwal ◽  
Shikha Rathi ◽  
Suresh Kumar ◽  
...  
Keyword(s):  
Pharmacokinetic Profile ◽  
Syringic Acid ◽  
Cancer Drug ◽  
The Novel ◽  
Anticancer Chemotherapy ◽  
Anti Cancer ◽  
Single Method ◽  
Vital Component ◽  
Viable Approach

Background: Taxanes constitute an important class of anti-cancer agents, which are widely prescribed for the management of cancers like breast, lung and ovaries. These agents belong to Biopharmaceutical Classification System (BCS) class IV, which are neither soluble in the aqueous systems nor permeable across the biological membranes. Objectve: Due to these concerns only, the oral bioavailabilities of these drugs are too low. Looking into these concerns, it was envisaged to develop co-crystals of docetaxel with syringic acid. Methods: For the preparation of co-crystals no single method is used. The methods range from spray drying, crystallization, ultrasonication and freeze drying to supercritical fluid methodologies. Results: The novel co-crystal not only improved the solubility and dissolution rates of the drug, but also resulted in improved pharmacokinetic profile. Conclusion: The present findings provide an economic and viable approach to improve the solubility and absorption profile of a drug, which is a vital component of the anticancer chemotherapy. Such studies provide a hope for the development of approaches to improve the solubility and permeability of drugs with challenges.

Cytotoxicity of the novel anti-cancer drug rViscumin depends on HER-2 levels in SKOV-3 cells

2004 ◽  
Vol 321 (2) ◽  
pp. 403-412 ◽  
Author(s):  
Shaker Abuharbeid ◽  
Jürgen Apel ◽  
Martin Sander ◽  
Babette Fiedler ◽  
Martin Langer ◽  
...  
Keyword(s):  
Cancer Drug ◽  
The Novel ◽  
Anti Cancer ◽  
Her 2

Cancer Chemotherapy by Novel Bio-active Natural Products: Looking Towards the Future

2019 ◽  
Vol 15 (1) ◽  
pp. 37-49
Author(s):  
Om Prakash ◽  
Shazia Usmani ◽  
Ruchi Singh ◽  
Debarshi K. Mahapatra ◽  
Amresh Gupta
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Cancer Drug ◽  
The Novel ◽  
Current Review ◽  
Chronic Disorder ◽  
Anti Cancer ◽  
The Us ◽  
Plant Sources ◽  
Active Natural

Background: Cancer is the second leading cause of death globally and accounted for 8.8 million deaths annually in humans. Lung, prostate, colorectal, stomach and liver cancer are the most common types of cancer in men, while breast, colorectal, lung, cervix and stomach cancer are the most common among women. Numerous drugs that the US Food and Drug Administration (FDA) have approved for use in cancer therapy are derived from plants, including taxanes such as paclitaxel and vinca alkaloids such as vincristine and vinblastine. Still, there is an intense need for a search for numerous bioactive sources to develop a novel anti-cancer drug to overcome this chronic disorder. About more than thirty plants derived natural products have been isolated till date and are currently under clinical trials. As per literature survey from various journals and texts has been found to be novel medicinal agents from bioactive sources are clinically active against various types of cancer cells. Conclusion: Current review has been highlighted on the novel medicinal agents from plant sources have potential effects against many types of cancer, which have been supported by clinical trials. The main findings of these active novel medicinal agents were also summarized and discussed here.

scholarly journals Cancer Immunotherapy Based on Carbon-Quantum-Dot Modified Cancer Cells

2021 ◽  
Author(s):  
Zikang Tang ◽  
Tao Liang ◽  
Josh Haipeng Lei ◽  
Jinsong Tao ◽  
Sen Guo ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
The Body ◽  
Conformational Structure ◽  
Primary Tumors ◽  
Carbon Quantum Dot ◽  
Anti Cancer ◽  
Personalized Cancer ◽  
Structure Of Proteins

Abstract Cancer immunotherapy based on carbon-quantum-dot (CQD) modified cancer cells (CM-cancer) has proven effective. The CQDs non-distinctively modify the conformational structure of proteins by hydrogen bonding between the protein chains and the permeated CQDs via a thermal treatment. CM-cancer vaccines exhibit robust immunogenicity, which can recruit macrophages and dendritic cells to effectively deliver the cancer antigens into lymph nodes to activate CD8+ T cells, and eventually leads to an anti-cancer immune response all over the body. The CM-cancer vaccinations are not only able to inhibit primary tumors, but also clearly eliminate metastatic tumors. Our research demonstrates a promising personalized cancer immunotheraputic technology for potential clinical applications.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6
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