Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Sophie R Cook ◽  
Hannah B Musgrove ◽  
Amy L Throckmorton ◽  
Rebecca R. Pompano
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Recirculating Flow ◽  
Nutrient Exchange ◽  
Chip Technology ◽  
On Chip ◽  
Fluid Cell

Fluid flow is an integral part of microfluidic and organ-on-chip technology, ideally providing biomimetic fluid, cell, and nutrient exchange as well as physiological or pathological shear stress. Currently, many of...

Multiprocessor transport surveillance video system based on "system on chip" technology

2020 ◽  
Author(s):  
Ш.С. Фахми ◽  
Н.В. Шаталова ◽  
В.В. Вислогузов ◽  
Е.В. Костикова
Keyword(s):  
System On Chip ◽  
Reference Points ◽  
Surveillance Video ◽  
Video Information ◽  
Chip Technology ◽  
Intelligent Video Surveillance System ◽  
Speed Up ◽  
Algorithmic Analysis ◽  
Computational Procedures ◽  
On Chip

В данной работе предлагаются математический аппарат и архитектура многопроцессорной транспортной системы на кристалле (МПТСнК). Выполнена программно-аппаратная реализация интеллектуальной системы видеонаблюдения на базе технологии «система на кристалле» и с использованием аппаратного ускорителя известного метода формирования опорных векторов. Архитектура включает в себя сложно-функциональные блоки анализа видеоинформации на базе параллельных алгоритмов нахождения опорных точек изображений и множества элементарных процессоров для выполнения сложных вычислительных процедур алгоритмов анализа с использованием средств проектирования на базе реконфигурируемой системы на кристалле, позволяющей оценить количество аппаратных ресурсов. Предлагаемая архитектура МПТСнК позволяет ускорить обработку и анализ видеоинформации при решении задач обнаружения и распознавания чрезвычайных ситуаций и подозрительных поведений. In this paper, we propose the mathematical apparatus and architecture of a multiprocessor transport system on a chip (MPTSoC). Software and hardware implementation of an intelligent video surveillance system based on the "system on chip" technology and using a hardware accelerator of the well-known method of forming reference vectors. The architecture includes complex functional blocks for analyzing video information based on parallel algorithms for finding image reference points and a set of elementary processors for performing complex computational procedures for algorithmic analysis. using design tools based on a reconfigurable system on chip that allows you to estimate the amount of hardware resources. The proposed MPTSoC architecture makes it possible to speed up the processing and analysis of video information when solving problems of detecting and recognizing emergencies and suspicious behaviors

The influence of magnetic field on wall shear stress in power law fluid flow of blood

2021 ◽  
Author(s):  
Amira Husni Talib ◽  
Ilyani Abdullah ◽  
Nik Nabilah Nik Mohd Naser
Keyword(s):  
Magnetic Field ◽  
Shear Stress ◽  
Fluid Flow ◽  
Wall Shear Stress ◽  
Power Law ◽  
Power Law Fluid ◽  
Wall Shear

scholarly journals The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3128
Author(s):  
Thomas R. Coughlin ◽  
Ali Sana ◽  
Kevin Voss ◽  
Abhilash Gadi ◽  
Upal Basu-Roy ◽  
...  
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Bone Cells ◽  
Bone Cancer ◽  
Substrate Stiffness ◽  
Flow Shear ◽  
Fluid Movement ◽  
Flow Shear Stress ◽  
Fluid Flow Shear Stress ◽  
New Treatments

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/physical surroundings and changes in these surroundings can affect their behavior. However, it is not well understood how OS cells specifically respond to fluid movement, or substrate stiffness—two stimuli of relevance in the tumor microenvironment. We used cells from spontaneous OS tumors in a mouse engineered to have a bone-specific knockout of pRb-1 and p53 in the osteoblast lineage. We silenced Sox2 (which regulates YAP) and tested the effect of fluid flow shear stress (FFSS) and substrate stiffness on YAP expression/activity—which was significantly reduced by loss of Sox2, but that effect was reversed by FFSS but not by substrate stiffness. Osteogenic gene expression was also reduced in the absence of Sox2 but again this was reversed by FFSS and remained largely unaffected by substrate stiffness. Thus we described the effect of two distinct stimuli on the mechanosensory and osteogenic profiles of OS cells. Taken together, these data suggest that modulation of fluid movement through, or stiffness levels within, OS tumors could represent a novel consideration in the development of new treatments to prevent their progression.

scholarly journals Microfluidic organ-on-chip technology for blood-brain barrier research

2016 ◽  
Vol 4 (1) ◽  
pp. e1142493 ◽  
Author(s):  
Marinke W van der Helm ◽  
Andries D van der Meer ◽  
Jan C T Eijkel ◽  
Albert van den Berg ◽  
Loes I Segerink
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Chip Technology ◽  
On Chip

Turbulence structure of a reattaching mixing layer

1981 ◽  
Vol 110 ◽  
pp. 171-194 ◽  
Author(s):  
C. Chandrsuda ◽  
P. Bradshaw
Keyword(s):  
Boundary Layer ◽  
Shear Stress ◽  
Reynolds Shear Stress ◽  
Mixing Layer ◽  
Three Dimensional ◽  
Flow Region ◽  
Turbulent Energy ◽  
Turbulence Structure ◽  
Hot Wire ◽  
Recirculating Flow

Hot-wire measurements of second- and third-order mean products of velocity fluctuations have been made in the flow behind a backward-facing step with a thin, laminar boundary layer at the top of the step. Measurements extend to a distance of about 12 step heights downstream of the step, and include parts of the recirculating-flow region: approximate limits of validity of hot-wire results are given. The Reynolds number based on step height is about 105, the mixing layer being fully turbulent (fully three-dimensional eddies) well before reattachment, and fairly close to self-preservation in contrast to the results of some previous workers. Rapid changes in turbulence quantities occur in the reattachment region: Reynolds shear stress and triple products decrease spectacularly, mainly because of the confinement of the large eddies by the solid surface. The terms in the turbulent energy and shear stress balances also change rapidly but are still far from the self-preserving boundary-layer state even at the end of the measurement region.

Measurement of Osteocyte Deformation Resulting From Fluid Flow Induced Shear Stress

1999 ◽  
Author(s):  
Daniel P. Nicolella ◽  
Eugene Sprague ◽  
Lynda Bonewald
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Flow Rate ◽  
Bone Cells ◽  
Individual Cell ◽  
Analysis Techniques ◽  
Sheer Stress ◽  
Increased Sensitivity ◽  
Cell Strains ◽  
Substrate Strain

Abstract It has been shown that bone cells are more responsive to fluid flow induced shear stress as compared to applied substrate strain (Owan, et al., 1997, Smalt, et al., 1997). Using novel micromechanical analysis techniques, we have measured individual cell strains resulting from 10 minutes of continuous fluid flow at a flow rate that produces a shear stress of 15 dyne/cm2. Individual cell strains varied widely from less than 1.0% to over 25% strain within the same group of cells. The increased sensitivity of cells to fluid flow induced shear stress may be attributed to much greater cellular deformations resulting from fluid flow induced sheer stress.

scholarly journals Endothelial Barrier Function is co-regulated at Vessel Bifurcations by Fluid Forces and Sphingosine-1-Phosphate

2020 ◽  
Author(s):  
Ehsan Akbari ◽  
Griffin B. Spychalski ◽  
Miles M. Menyhert ◽  
Kaushik K. Rangharajan ◽  
Shaurya Prakash ◽  
...  
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Barrier Function ◽  
Endothelial Barrier ◽  
Laminar Shear Stress ◽  
Endothelial Barrier Function ◽  
Fluid Forces ◽  
Sphingosine 1 Phosphate ◽  
Laminar Shear ◽  
Vessel Bifurcations

AbstractSphingosine-1-phosphate (S1P) is a blood-borne bioactive lipid mediator of endothelial barrier function. Prior studies have implicated mechanical stimulation due to intravascular laminar shear stress in co-regulating S1P signaling in endothelial cells (ECs). Yet, vascular networks in vivo consist of vessel bifurcations, and this geometry produces hemodynamic forces that are distinct from laminar shear stress. However, the role of these forces at vessel bifurcations in regulating S1P-dependent endothelial barrier function is not known. In this study, we implemented a microfluidic platform that recapitulates the flow dynamics of vessel bifurcations with in situ quantification of the permeability of microvessel analogues. Co-application of S1P with impinging bifurcated fluid flow, which was characterized by approximately zero shear stress and 38 dyn cm-2 stagnation pressure at the vessel bifurcation point, promotes vessel stabilization. Similarly, co-treatment of carrier-free S1P with 3 dyn cm-2 laminar shear stress is also protective of endothelial barrier function. Moreover, it is shown that vessel stabilization due to laminar shear stress, but not bifurcated fluid flow, is dependent on S1P receptor 1 or 2 signaling. Collectively, these findings demonstrate the endothelium-protective function of fluid forces at vessel bifurcations and their involvement in coordinating S1P-dependent regulation of vessel permeability.

scholarly journals FLUID FLOW AND WALL SHEAR STRESS PROFILES IN MODEL BRANCH OF ABDOMINAL AORTA

Biomechanisms ◽  
1992 ◽  
Vol 11 (0) ◽  
pp. 99-109 ◽  
Author(s):  
Takashi HIROSE ◽  
Akio TANABE ◽  
Kazuo TANISHITA
Keyword(s):  
Shear Stress ◽  
Fluid Flow ◽  
Wall Shear Stress ◽  
Abdominal Aorta ◽  
Stress Profiles ◽  
Wall Shear

scholarly journals Recent Advances in Hearing Aid Technology-A Review

2021 ◽  
Vol 9 (VI) ◽  
pp. 3427-3429
Author(s):  
Animita Das
Keyword(s):  
Hearing Aids ◽  
Hearing Aid ◽  
Cost Effective ◽  
System On Chip ◽  
Audio Signals ◽  
Technology System ◽  
The People ◽  
Chip Technology ◽  
On Chip ◽  
System 1

Hearing aids are electroacoustic gadgets commonly worn in or behind the ear and are intended to enhance the speech Nowadays hearing aids support various application unlike the traditional ones such that it can act like headphones streaming audio signals from internet-enabled devices connected wirelessly via Bluetooth. This paper aims to review the various advancements in the hearing aid technology. System on chip technology of the microcontroller have been used in various studies to develop and design an effective hearing assistant device and help the people with hearing impairment to lead a normal life. Ten articles have been reviewed for the study and it can be concluded that IoT is the future for an efficient, cost effective hearing assistive system [1]

scholarly journals Methods and applications of label-free cell-based systems

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Joachim Wiest
Keyword(s):  
Environmental Monitoring ◽  
Morphological Changes ◽  
Free Cell ◽  
Living Cells ◽  
Label Free ◽  
Controlled System ◽  
Chip Technology ◽  
Cell Monitoring ◽  
A Cell ◽  
On Chip

Label-free monitoring of living cells is used in various applications such as drug development, toxicology, regenerative medicine or environmental monitoring. The most prominent methods for monitoring the extracellular acidification, oxygen consumption, electrophysiological activity and morphological changes of living cells are described. Furthermore, the intelligent mobile lab (IMOLA) – a computer controlled system integrating cell monitoring and automated cell cultivation – is described as an example of a cell-based system for microphysiometry. Results from experiments in the field of environmental monitoring using algae are presented. An outlook toward the development of an organ-on-chip technology is given.

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