Direct Isolation of Circulating Extracellular Vesicles from Blood for Vascular Risk Profiling in Type 2 Diabetes Mellitus

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Hui Min Tay ◽  
Sheng Yuan Leong ◽  
Xiaohan Xu ◽  
Fang Kong ◽  
Megha Upadya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Extracellular Vesicles ◽  
Whole Blood ◽  
Vascular Risk ◽  
Risk Profiling

Extracellular vesicles (EVs) are key mediators of communication among cells, and clinical utilities of EVs-based biomarkers remain limited due to difficulties in isolating EVs from whole blood reliably. We report...

scholarly journals Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy

2019 ◽  
Vol 8 (1) ◽  
pp. 1625677 ◽  
Author(s):  
Yongwei Xiao ◽  
Lei Zheng ◽  
Xiaofeng Zou ◽  
Jigang Wang ◽  
Jianing Zhong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Extracellular Vesicles

CHRONIC HEART FAILURE PATIENTS WITH TYPE 2 DIABETES MELLITUS DETERIORATES 24 HOURS ABPM, VASCULAR RISK PROFILE AND VENTRICULAR FUNCTION

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e208-e209
Author(s):  
A.M. Gonzalez Gonzalez ◽  
P. Guardia Martinez ◽  
A.M. Garcia Bellon ◽  
D. Gaitan Roman ◽  
M. de Mora Martin
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Heart Failure ◽  
Ventricular Function ◽  
Risk Profile ◽  
Vascular Risk ◽  
Heart Failure Patients

scholarly journals The Role Of Elevated NT-ProbNP And Albuminuria As Cardio-Vascular Risk Factors In Type 2 Diabetes Mellitus Patients After Acute Coronary Syndrome

2015 ◽  
Vol 22 (2) ◽  
pp. 141-149
Author(s):  
Johann Trutz ◽  
Aurel Babeş ◽  
Katalin Babeş
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Independent Risk Factor ◽  
Vascular Risk ◽  
Short Term ◽  
Coronary Syndrome ◽  
Cardio Vascular

AbstractBackground and Aims. The identification of type 2 diabetes mellitus (T2DM) patients with high cardio-vascular risk became more crucial, especially in patients with known coronary artery disease (CAD). Our study is focusing on T2DM patients who suffered recently an acute coronary syndrome (ACS), and evaluates the importance of albuminuria and NT-proBNP level as risk factors for short-term recurrence.Material and methods. 221 T2DM patients with recent ACS were evaluated 1 month after discharge, assessing NT-proBNP and albuminuria level and followed for 12 months for major adverse cardiac events (MACE).Results. Patients who reached the endpoint (33%) presented significantly higher levels of NT-proBNP (458.5 vs. 207.4 pg/ml, p<0.0001) and urinary albumin/creatinine ratio (80 vs. 27 mg/g, p<0.0001) than those who did not present a MACE in the follow-up period. Comparison of the MACE-free survival curves revealed that NT-proBNP has a better power than albuminuria in the prediction of the short-term outcome: hazard ratio (HR)=1.6176 (95%CI: 1.0047-2.6044), p=0.0433 vs. HR=1.4813 (95%CI: 0.8497-2.5824), p=0.1921. Only the NT-proBNP level entered the multivariable regression model besides age and represents an independent risk factor (HR=1.0025, 95%CI: 1.0014-1.0035, p=0.0036).Conclusion. NT-proBNP provides excellent prognostic information in patients with diabetes mellitus who recently suffered an ACS. Albuminuria wasn’t an independent risk factor in this cohort.

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