Carbon Dioxide-Promoted Three-Component Strecker Reaction

2021 ◽  
Author(s):  
Ruslan V. Fauziev ◽  
Roman E. Ivanov ◽  
Ilya Kuchurov ◽  
Sergei Grigorievich Zlotin
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Strecker Reaction ◽  
First Time ◽  
Supercritical Carbon

Three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure non-toxic and non-flammable carbon dioxide acts not...

scholarly journals Low-temperature and purification-free stereocontrolled ring-opening polymerisation of lactide in supercritical carbon dioxide

2020 ◽  
Vol 22 (7) ◽  
pp. 2197-2202 ◽  
Author(s):  
Simon P. Bassett ◽  
Andrew D. Russell ◽  
Paul McKeown ◽  
Isabel Robinson ◽  
Thomas R. Forder ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Low Temperature ◽  
Supercritical Carbon Dioxide ◽  
Ring Opening ◽  
Solvent Free ◽  
Free Ring ◽  
First Time ◽  
Supercritical Carbon

A stereoselective, solvent-free ring-opening polymerisation (ROP) of lactide (LA) in supercritical carbon dioxide (scCO2) is reported for the first time.

Body temperature polymerization and in situ drug encapsulation in supercritical carbon dioxide

2020 ◽  
Vol 11 (42) ◽  
pp. 6821-6831
Author(s):  
Zi-Kun Rao ◽  
Tian-Qiang Wang ◽  
Yang Li ◽  
Hong-Yu Zhu ◽  
Yu Liu ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Body Temperature ◽  
Supercritical Carbon Dioxide ◽  
Solvent Free ◽  
Drug Encapsulation ◽  
First Time ◽  
Supercritical Carbon

Body-temperature and solvent-free polymerization and in situ fabrication of drug-loaded microparticles are reported for the first time.

scholarly journals One-pot synthesis of micron-sized polybetaine particles; innovative use of supercritical carbon dioxide

2017 ◽  
Vol 8 (31) ◽  
pp. 4557-4564 ◽  
Author(s):  
Simon P. Bassett ◽  
Natasha A. Birkin ◽  
James Jennings ◽  
Emma Chapman ◽  
Rachel K. O'Reilly ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
One Pot ◽  
One Pot Synthesis ◽  
Methanol Mixture ◽  
First Time ◽  
Supercritical Carbon

Well defined micron-sized polybetaine particles have been synthesised for the first time by precipitation polymerisation in a scCO2/methanol mixture.

scholarly journals Effects of Supercritical Carbon Dioxide Extraction (SC-CO2) on the content of tiliroside in the extracts from Tilia L. flowers

2019 ◽  
Vol 17 (1) ◽  
pp. 302-312 ◽  
Author(s):  
Aleksandra Pieczykolan ◽  
Wioleta Pietrzak ◽  
Edward Rój ◽  
Renata Nowak
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Ethanol Concentration ◽  
Wide Spectrum ◽  
Total Phenolic ◽  
Supercritical Carbon Dioxide Extraction ◽  
Carbon Dioxide Extraction ◽  
First Time ◽  
Optimum Extraction ◽  
Supercritical Carbon

AbstractTiliroside is one of the main flavonoid compounds responsible for a wide spectrum of biological activity of Tilia L. Up to now, several extraction techniques have been reported for extracting this compound from Tilia L. In this work for the first time supercritical carbon dioxide extraction was used for this purpose. Experiments were performed using supercritical carbon dioxide with 5% and 10% of ethanol as solvent, aiming a recovery content of tiliroside, temperature from 45 to 80°C, pressure from 100 to 220 bar and time from 20 to 60 minutes. The statistically generated optimum extraction conditions to obtain the highest content of tiliroside were established as: pressure of 200 bar, temperature 65°C and 45-50 minutes for 5% ethanol concentration and pressure of 220 bar, temperature 65°C and 15 minutes for 10% ethanol concentration.A liquid chromatography-electrospray ionization-tandem mass spectrometry method (LC-ESI-MS/MS) was used to determine the content of tiliroside in the obtained extracts. In addition, the total phenolic (TPC) and flavonoid (TFC) content and antioxidant activity (DPPH• method) were determined.

scholarly journals Measurement and Modeling of Clemastine Fumarate (Antihistamine Drug) Solubility in Supercritical Carbon Dioxide

2021 ◽  
Author(s):  
Gholamhossein Sodeifian ◽  
Chandrasekhar Garlapati ◽  
Fariba Razmimanesh ◽  
Marziehsadat Ghanaat-Ghamsari
Keyword(s):  
Carbon Dioxide ◽  
Equation Of State ◽  
Supercritical Carbon Dioxide ◽  
Information Criterion ◽  
Drug Solubility ◽  
Relative Deviation ◽  
Antihistamine Drug ◽  
First Time ◽  
Robinson Equation ◽  
Supercritical Carbon

Abstract The solubilities of clemastine fumarate in supercritical carbon dioxide) ScCO2( were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). The measured solubilities were reported in terms of mole faction and it is ranged from 1.61 ×10− 6 to 9.41×10− 6. Various models were used to correlate the data. The efficacy of the models was quantified with corrected Akaike’s information criterion (AICc). A new cluster salvation model was derived to correlate the solubility data. The new model was able to correlate the data and deviation was 10.3% in terms of average absolute relative deviation (AARD). Furthermore, the measured solubilities were also correlated with existing K.-W. Chen et al., cluster salvation model, equation of state (EoS) model and few density models. Among density models, Tippana and Garlapati model was observed to be the best model and corresponding AARD% was 7.57 (corresponding AICc is -678.88). The Peng-Robinson equation of state as temperature independent was able to correlate the data and deviation was 8.25% in terms of AARD% (corresponding AICc is -674.88). Moreover, thermodynamic enthalpies of clemastine fumarate were estimated.

scholarly journals Measurement and modeling of clemastine fumarate (antihistamine drug) solubility in supercritical carbon dioxide

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gholamhossein Sodeifian ◽  
Chandrasekhar Garlapati ◽  
Fariba Razmimanesh ◽  
Marziehsadat Ghanaat-Ghamsari
Keyword(s):  
Carbon Dioxide ◽  
Equation Of State ◽  
Supercritical Carbon Dioxide ◽  
Information Criterion ◽  
Drug Solubility ◽  
Heats Of Reaction ◽  
Antihistamine Drug ◽  
First Time ◽  
Robinson Equation ◽  
Supercritical Carbon

AbstractThe solubilities of clemastine fumarate in supercritical carbon dioxide (ScCO2) were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). The measured solubilities were reported in terms of mole faction (mol/mol total) and it had a range from 1.61 × 10–6 to 9.41 × 10–6. Various models were used to correlate the data. The efficacy of the models was quantified with corrected Akaike’s information criterion (AICc). A new cluster salvation model was derived to correlate the solubility data. The new model was able to correlate the data and deviation was 10.3% in terms of average absolute relative deviation (AARD). Furthermore, the measured solubilities were also correlated with existing K.-W. Chen et al., model, equation of state model and a few other density models. Among density models, Reddy and Garlapati model was observed to be the best model and corresponding AARD was 7.57% (corresponding AICc was − 678.88). The temperature independent Peng–Robinson equation of state was able to correlate the data and AARD was 8.25% (corresponding AICc was − 674.88). Thermodynamic parameters like heats of reaction, sublimation and solvation of clemastine fumarate were calculated and reported.

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