Environment-friendly and efficient synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor

2021 ◽  
Author(s):  
Yaning Xu ◽  
Fengxi Li ◽  
Nan Zhao ◽  
Jiali Su ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Vitreoscilla Hemoglobin ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Cobalt Porphyrin

In this work, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We demonstrate an expression-based porphyrin substitution strategy to produce...

scholarly journals An Efficient Synthesis of 4-Aminomethyl-1-(2-Phenylethyl)-Piperidin-4-ol: A Key Intermediate in Fenspiride HCl Synthesis

2021 ◽  
pp. 139-146
Author(s):  
Prasad Panchabhai ◽  
Neelakandan Kaliaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Anbuselvan Chinnadurai
Keyword(s):  
Green Chemistry ◽  
Hazardous Waste ◽  
Building Block ◽  
Manufacturing Process ◽  
Good Yield ◽  
Aqueous Ammonia ◽  
Scale Production ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Bulk Scale

The article confers a scalable manufacturing process of Fenspiride HCl. 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol is the main building block in Fenspiride HCl synthesis. The reported reagents for 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis are costly, explosive, highly toxic, produce hazardous waste, and also need to be handled with most care. The paper introduces aqueous ammonia as an alternate reagent in Fenspiride HCl and used in 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis. The new green chemistry aspect makes the process environment-friendly and cheaper. It also eliminates toxic, sensitive, and hazardous reagents and makes the process safe on uncomplicated on bulk scale production. The high pure Fenspiride HCl is obtained by following this process and meets the ICH limits with good yield.

Synthesis of Medicinally Relevant Scaffolds-Triazoles and Pyrazoles in Green Solvent Ionic Liquids

2021 ◽  
Vol 25 ◽  
Author(s):  
Parmita Phukan ◽  
Diganta Sarma
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Public Sector ◽  
Chemical Industry ◽  
Constant Pressure ◽  
Energy Sources ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Tremendous Importance

: The use of natural and environment friendly energy sources for betterment of the living society has become an active concern in both government and public sector. Due to this, responsible use of global resources has become a growing concern among people. Similarly, in chemical industry especially in pharmaceutical fields, there is constant pressure in reducing hazardous organic solvents and environmentally detrimental laboratory materials. The use of ionic liquids in efficient synthesis of a wide array of fundamentally important structural motifs has gained tremendous importance in the scientific era. In this review, synthesis of two such medicinally relevant moieties, namely, triazole and pyrazole, in green and sustainable ionic liquid have been discussed.

Synthesis of Novel Drug Benvitimod

2011 ◽  
Vol 236-238 ◽  
pp. 2378-2382 ◽  
Author(s):  
Jun Gang Gao ◽  
Yue Zhang ◽  
He Tang Zheng ◽  
Chun Fang Wang ◽  
Hui Xian Liu ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Total Yield ◽  
Synthesis Method ◽  
Efficient Synthesis ◽  
Improved Method ◽  
Environment Friendly ◽  
Mild Conditions ◽  
Common Skin ◽  
Novel Drug ◽  
The Ideal

Benvitimod (3,5-dihydroxy-4-i-propylstilbene) is a novel drug developed for common skin disorders such as atopic dermatitis by Welichem Biotech Inc. in Canada and Celestial Pharmaceuticals (Shenzhen) Co. Ltd. in China. But the ideal synthesis method is not reported so far. Herein an efficient synthesis method which is operated under the mild conditions is reported. According this route, the total yield will reach 40.3 - 48.1% and the benefits of the improved method are easily operating and environment friendly.

scholarly journals ENVIRONMENT-FRIENDLY GREEN APPROACHES FOR AN EFFICIENT SYNTHESIS OF 2H-INDAZOLO [2,1-b] PHTHALAZINE-1,6,11 (13H)-TRIONES CATALYZED BY TANNIC ACID

2019 ◽  
Vol 64 (8) ◽  
pp. 645-650
Author(s):  
Davood SHEIKH ◽  
◽  
Ali VARASTEH MORADI ◽  
Zahra HEKMATIAN ◽  
◽  
...  
Keyword(s):  
Tannic Acid ◽  
Efficient Synthesis ◽  
Environment Friendly

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis

Construction of Safe, Reliable, Clean, and Environment-Friendly Refining and Chemical Enterprises

2019 ◽  
Vol 21 (2) ◽  
pp. 111
Author(s):  
Shucai Zhang ◽  
Xiaohua Zhang ◽  
Ping Jia ◽  
Qian Wang ◽  
Xianghong Cao
Keyword(s):  
Environment Friendly

Mikania micrantha mixed woven fabric for quick blood clotting and wound healing

2020 ◽  
Vol 6 (5) ◽  
Author(s):  
Shaikh Md Mominul Alam ◽  
Shilpi Akter ◽  
Md Lutfor Rahman
Keyword(s):  
Wound Healing ◽  
Blood Clotting ◽  
Woven Fabric ◽  
Excessive Bleeding ◽  
Sustainable Operations ◽  
Environment Friendly ◽  
Mikania Micrantha ◽  
Leaf Powder ◽  
Medical Textile ◽  
Dressing Materials

The aim of this paper is to introduce novel dressing with Mikania Micrantha for quick blood clotting and wound healing. When epidermis of human skin is cut or scrapped, sometimes too much bleeding occurs. Excessive bleeding may cause death, if bleeding is not stopped immediately. To promote blood clotting & wound healing natural based bio materials are still insufficient in medical textile sector. To fill up this scarcity, woven fabric treated with Mikania micrantha leaf juice & leaf powder was examined. M. micrantha exhibits good blood clotting time in comparison with available dressing materials. Woven fabric (bandage) that contains M. micrantha can be used for cut wounds healing purpose. The experiments were carried out in environment friendly way which indicates the production & processing of these dressing materials can have enormous contribution to sustainable operations and products.

ENVIRONMENT-FRIENDLY COMPOSITE PROPELLANTS BASED ON AMMONIUM DINITRAMIDE

2019 ◽  
Vol 18 (1) ◽  
pp. 31-49
Author(s):  
Volker Gettwert ◽  
Volker Weiser ◽  
Claudio Tagliabue ◽  
Sven Hafner ◽  
Sebastian Fischer
Keyword(s):  
Ammonium Dinitramide ◽  
Environment Friendly
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