Chitosan Nanocrystals Synthesis via Aging and Application Towards Alginate Hydrogels for Sustainable Drug Release

2021 ◽  
Author(s):  
Tony Jin ◽  
Tracy Liu ◽  
Shuaibing Jiang ◽  
Davis Kurdyla ◽  
Vladimir Michaelis ◽  
...  
Keyword(s):  
Drug Release ◽  
Biomass Waste ◽  
Marine Biomass ◽  
Alginate Hydrogels ◽  
Material Extraction

Marine biomass waste is a remarkable source of functional molecules and materials. Yet material extraction, conversion and processing are often chemically intensive, preventing the widespread and clean use of these...

Albumin-crosslinked alginate hydrogels as sustained drug release carrier

2007 ◽  
Vol 27 (4) ◽  
pp. 870-874 ◽  
Author(s):  
Daisuke Tada ◽  
Toshizumi Tanabe ◽  
Akira Tachibana ◽  
Kiyoshi Yamauchi
Keyword(s):  
Drug Release ◽  
Sustained Drug Release ◽  
Alginate Hydrogels

Near-infrared light-responsive alginate hydrogels based on diselenide-containing cross-linkage for on demand degradation and drug release

2019 ◽  
Vol 223 ◽  
pp. 115070 ◽  
Author(s):  
Daru Seto Bagus Anugrah ◽  
Kaylan Ramesh ◽  
Mingeun Kim ◽  
Kyu Hyun ◽  
Kwon Taek Lim
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand ◽  
Alginate Hydrogels ◽  
Cross Linkage

Highly scalable production of uniformly-coated superparamagnetic nanoparticles for triggered drug release from alginate hydrogels

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21503-21510 ◽  
Author(s):  
Alexandra Teleki ◽  
Florian L. Haufe ◽  
Ann M. Hirt ◽  
Sotiris E. Pratsinis ◽  
Georgios A. Sotiriou
Keyword(s):  
Drug Release ◽  
Large Scale ◽  
Superparamagnetic Nanoparticles ◽  
Scale Production ◽  
Stimuli Responsive ◽  
Alginate Hydrogel ◽  
Large Scale Production ◽  
Alginate Hydrogels ◽  
Triggered Drug Release ◽  
Scalable Production

Large-scale production of SiO2-coated Fe2O3nanoparticles facilitates their incorporation in stimuli-responsive superparamagnetic alginate hydrogel structures with efficient hyperthermia performance and enhanced triggered drug release.

scholarly journals Chitosan Nanocrystals Synthesis via Aging and Application Towards Alginate Hydrogels for Sustainable Drug Release

2021 ◽  
Author(s):  
Tony Jin ◽  
Tracy Liu ◽  
Shuaibing Jiang ◽  
Vladimir Michaelis ◽  
David Kurdyla ◽  
...  
Keyword(s):  
Drug Release ◽  
Building Block ◽  
Alginate Hydrogels

In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase the greeness of this method. We are then using these materials as building block to fabricate alginate hydrogels, and demonstrated that they have superior properties for gelation and drug release.<br>

scholarly journals Chitosan Nanocrystals Synthesis via Aging and Application Towards Alginate Hydrogels for Sustainable Drug Release

2021 ◽  
Author(s):  
Tony Jin ◽  
Tracy Liu ◽  
Shuaibing Jiang ◽  
Vladimir Michaelis ◽  
David Kurdyla ◽  
...  
Keyword(s):  
Drug Release ◽  
Building Block ◽  
Alginate Hydrogels

In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase the greeness of this method. We are then using these materials as building block to fabricate alginate hydrogels, and demonstrated that they have superior properties for gelation and drug release.<br>

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

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