Mechanism of enhancing the water-solubility and stability of curcumin by self-assembled cod protein nanoparticles at alkaline pH

2021 ◽  
Author(s):  
Yuying Wang ◽  
Ruitong Sun ◽  
Xian-Bing Xu ◽  
Ming Du ◽  
Bei-Wei Zhu ◽  
...  
Keyword(s):  
Water Solubility ◽  
Alkaline Ph ◽  
Chemical Instability ◽  
Protein Nanoparticles ◽  
Health Promoting ◽  
Poor Water Solubility ◽  
Self Assembled

Curcumin (Cur) is a bioactive phytochemical claimed to have several health-promoting benefits, whose applications are challenged due to its poor water-solubility, chemical instability, and low bioavailability. In this research, the...

NMR Studies of the Inclusion Complexes Between Ezetimibe and Cyclodextrins

2018 ◽  
Vol 69 (7) ◽  
pp. 1838-1841
Author(s):  
Hajnal Kelemen ◽  
Angella Csillag ◽  
Bela Noszal ◽  
Gabor Orgovan
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Water Solubility ◽  
Solution Nmr ◽  
Spectroscopic Techniques ◽  
Nmr Studies ◽  
The Poor ◽  
Poor Water Solubility

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK[3). The least stable inclusion complex is formed with b-cyclodextrin, while the ezetimibe-methylated-b--cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.

scholarly journals Design of integrin αvβ3 targeting self-assembled protein nanoparticles with RGD peptide

2020 ◽  
Vol 128 ◽  
pp. 110236
Author(s):  
Xiangfeng Lv ◽  
Chun Zhang ◽  
Qingyun Shuaizhen ◽  
Rong Yu ◽  
Yongxiang Zheng
Keyword(s):  
Integrin Αvβ3 ◽  
Rgd Peptide ◽  
Protein Nanoparticles ◽  
Self Assembled

Solid lipid nanoparticles of stearic acid for the drug delivery of paliperidone

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68743-68750 ◽  
Author(s):  
Sacheen Kumar ◽  
Jaspreet Kaur Randhawa
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Antipsychotic Drug ◽  
Solid Lipid Nanoparticles ◽  
Water Solubility ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Poor Water Solubility

Paliperidone is an antipsychotic drug having poor water solubility and bioavailability. Solid lipid nanoparticles of stearic acid loaded with paliperidone were prepared to enhance the bioavailability.

scholarly journals Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1372
Author(s):  
Chun-Yin Yang ◽  
Pao-Hsien Huang ◽  
Chih-Hua Tseng ◽  
Feng-Lin Yen
Keyword(s):  
Water Solubility ◽  
Methanol Extract ◽  
Biological Effects ◽  
Skin Permeation ◽  
Environmental Pollutants ◽  
Skin Penetration ◽  
Physicochemical Characteristics ◽  
The Poor ◽  
Deep Layers ◽  
Poor Water Solubility

Antioxidants from plant extracts are often used as additives in skincare products to prevent skin problems induced by environmental pollutants. Artocarpus communis methanol extract (ACM) has many biological effects, such as antioxidant, anti-inflammatory, wound healing, and photoprotective effects; however, the poor water solubility of raw ACM has limited its applications in medicine and cosmetics. Topical antioxidant nanoparticles are one of the drug-delivery systems for overcoming the poor water solubility of antioxidants for increasing their skin penetration. The present study demonstrated that ACM-loaded hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone K30 nanoparticles (AHP) were successfully prepared and could effectively increase the skin penetration of ACM through changing the physicochemical characteristics of raw ACM, including reducing the particle size, increasing the surface area, and inducing amorphous transformation. Our results also revealed that AHP had significantly better antioxidant activity than raw ACM for preventing photocytotoxicity because the AHP formulation increased the cellular uptake of the ACM in UVB-irradiated HaCaT keratinocytes. In conclusion, our results suggest that AHP may be used as a good topical antioxidant nanoparticle for delivering ACM into deep layers of the skin for preventing UVB-induced skin problems.

Phospholipid-containing films for improved drug release

2021 ◽  
pp. 30-33
Author(s):  
Jiahao Huang ◽  
◽  
Shawn Wettig
Keyword(s):  
Water Solubility ◽  
Aqueous Media ◽  
Active Pharmaceutical Ingredients ◽  
Natural Sources ◽  
Pharmaceutical Ingredients ◽  
Alternative Approach ◽  
Poor Water Solubility ◽  
Dissolution Efficiency ◽  
Oral Films ◽  
Liquid Liquid Phase Separation

Phospholipids from natural sources can delay liquid-liquid phase separation and improve supersaturation for active pharmaceutical ingredients with poor water-solubility in aqueous media. Researchers have developed oral films containing phospholipids to enhance the dissolution efficiency of hydrophobic pharmaceutical ingredients. Phospholipid-based oral films provide an alternative approach for compounding pharmacies to formulate drugs with poor water solubility.

scholarly journals Boiling Licorice Produces Self-Assembled Protein Nanoparticles: A Novel Source of Bioactive Nanomaterials

2019 ◽  
Vol 67 (33) ◽  
pp. 9354-9361 ◽  
Author(s):  
Jianwu Zhou ◽  
Jian Zhang ◽  
Guanzhen Gao ◽  
Huiqin Wang ◽  
Xiaoyan He ◽  
...  
Keyword(s):  
Protein Nanoparticles ◽  
Self Assembled

scholarly journals Protein Nanoparticles: A Novel Self-Assembled Mitochondria-Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer (Small 2/2019)

Small ◽  
2019 ◽  
Vol 15 (2) ◽  
pp. 1970010
Author(s):  
Xin-Jie Zhu ◽  
Ri-Fei Li ◽  
Liang Xu ◽  
Hui Yin ◽  
Long Chen ◽  
...  
Keyword(s):  
Protein Nanoparticles ◽  
Self Assembled ◽  
Mitochondria Targeting
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