A comprehensive investigation on chemical diversity and efficacy of different parts of Ligusticum chuanxiong

2022 ◽  
Author(s):  
Hongling Yan ◽  
Yinlin Zhou ◽  
Fei Tang ◽  
Chengjiu Wang ◽  
Jing Wu ◽  
...  
Keyword(s):  
Chemical Diversity ◽  
Edible Plant ◽  
Comprehensive Investigation ◽  
Ligusticum Chuanxiong ◽  
Biological Interest ◽  
Wide Range ◽  
Different Parts

Ligusticum chuanxiong Hort. (CX) is a medicinal and edible plant with a wide range of constituents of biological interest. Since the biomass of the non-medicinal parts of CX is huge,...

scholarly journals Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals

2021 ◽  
Author(s):  
Hui Wang ◽  
Hanbo Zhao ◽  
Yujia Chu ◽  
Jiang Feng ◽  
Keping Sun
Keyword(s):  
Adaptive Evolution ◽  
Hair Cells ◽  
High Frequency ◽  
Phylogenetic Trees ◽  
Outer Hair Cells ◽  
Functional Domain ◽  
Coding Region ◽  
Selective Pressures ◽  
Wide Range ◽  
Different Parts

Abstract High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we present two additional candidate hearing-related genes, Shh and SK2, that may also have contributed to the evolution of echolocation in mammals. Shh is a member of the vertebrate Hedgehog gene family and is required in the specification of the mammalian cochlea. SK2 is expressed in both inner and outer hair cells, and it plays an important role in the auditory system. The coding region sequences of Shh and SK2 were obtained from a wide range of mammals with and without echolocating ability. The topologies of phylogenetic trees constructed using Shh and SK2 were different; however, multiple molecular evolutionary analyses showed that those two genes experienced different selective pressures in echolocating bats and toothed whales compared to non-echolocating mammals. In addition, several nominally significant positively selected sites were detected in the non-functional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene. This study has expanded our knowledge of the adaptive evolution of high-frequency hearing in echolocating mammals.

scholarly journals 1258. Activity of a Series of Investigational Compounds Tested Against Invasive Fungal Isolates

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S645-S646
Author(s):  
Paul R Rhomberg ◽  
Shawn A Messer ◽  
Richard W Scott ◽  
Simon D P Baugh ◽  
Michael A Pfaller ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Chemical Diversity ◽  
Candida Auris ◽  
Services Research ◽  
Defense Proteins ◽  
Fungal Isolates ◽  
Wide Range ◽  
Cryptococcus Spp ◽  
Center Research ◽  
Research Grant

Abstract Background Fox Chase Chemical Diversity Center (FCC) is developing non-peptide analogs of host defense proteins for the treatment of invasive fungal infections mainly caused by Candida (CAN) and Aspergillus (ASP). We evaluated the activity of 6 novel compounds and 2 comparators against 150 isolates from 15 fungal groups. Methods Susceptibility testing was performed per CLSI broth microdilution methods for investigational compounds and comparators against 70 CAN and 40 ASP isolates in addition to 10 Cryptococcus spp. (CRYP), 10 Fusarium spp. (FUS), 10 Mucorales, and 10 Scedosporium spp. (SCED) isolates from recent (2017-2019) clinical infections. MIC results were determined as ≥ 50% reduction at 24 and 72 hours for CAN and CRYP respectively, and 100% reduction at 24, 72, and 48 hours for Mucorales, SCED, and other moulds, respectively. CLSI clinical breakpoint (CBP) and epidemiological cutoff value (ECV) interpretive criteria were applied for comparators. Results Compounds FC10790, FC11083, FC11212, and FC11275 had MIC50 results at ≤ 0.015 mg/L and MIC90 results at ≤ 0.015 to 0.12 mg/L against CRYP, ASP, and FUS isolates. Compounds FC5096 and FC11022 were 2- to 4-fold less active while demonstrating MIC50 and MIC90 results of 0.03 to 0.5 mg/L against CAN, CRYP, ASP, and FUS isolates. The Mucorales isolate set showed the widest range of MIC results for FC compounds. FC10790 exhibited the greatest potency with a MIC50/90 at 0.5/2 mg/L. FC compounds showed potent activity against SCED with MIC90 results of 0.03 to 0.25 mg/L. Fluconazole showed a wide range of MIC results, from 0.06 to >64 mg/L, but the highest results observed were for Candida auris (MIC50/90, 64/ > 64 mg/L) and Candida krusei (MIC50/90; 16/32 mg/L). Itraconazole was active against all ASP (MIC50/90, 1/1 mg/L), but showed poor activity against FUS (MIC50/90, > 8/ > 8 mg/L). Amphotericin B showed a narrow range of MIC results (0.5 to 2 mg/L) for all isolates except 1 ASP and most SCED. Conclusion Novel FCC compounds showed equal or greater activity than comparators against most CAN, ASP, SCED, and FUS. FC10790, FC11212, and FC11275 showed the greatest activity against all tested fungal isolates. development of this series of compounds for clinical studies. Table 1 Disclosures Paul R. Rhomberg, n/a, Cidara Therapeutics (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)Merck (Research Grant or Support) Shawn A. Messer, PhD, Amplyx Pharmaceuticals (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support) Richard W. Scott, PhD, Fox Chase Chemical Diversity Center (Employee) Simon DP Baugh, PhD, Fox Chase Chemical Diversity Center (Employee) Michael A. Pfaller, MD, Amplyx Pharmaceuticals (Research Grant or Support)Basilea Pharmaceutica International, Ltd (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Department of Health and Human Services (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support) Mariana Castanheira, PhD, 1928 Diagnostics (Research Grant or Support)A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Amplyx Pharmaceuticals (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support) Cecilia G. Carvalhaes, MD, PhD, A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Pfizer (Research Grant or Support)

Review on pharmacological and phytochemical prospects of traditional medicinal plant: Persicaria hydropiper (Smartweed)

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdul Nasir ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zeeshan Bhatti ◽  
Ashfaq Ur Rehman ◽  
Jiayi Li ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Northern Hemisphere ◽  
Biological Activities ◽  
Folk Medicine ◽  
Present Review ◽  
Polygonum Hydropiper ◽  
Wide Range ◽  
Pharmacological Data ◽  
Different Parts

: Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone including China, Bangladesh, India, and Japan. The plant is used in folk medicine for numerous ailments such as hemorrhoids, antifertility, diarrhea, and dyspepsia. Its medicinal usage in Unani, Ayurveda, Siddha, and other traditional medicine is well-recognized. So far, a wide range of active phytochemicals of this plant has been identified, such as flavonoids, sulphated flavonoids, terpenoids, anthraquinones, steroids, coumarin, simple phenolics, and others. Pharmacological data reported in the literature suggest that various parts of P. hydropiper exhibit antimicrobial, antioxidant, hypoglycemic, antidepressant, cardioprotective, hepatoprotective, anticancer, and antifertility effects. The present review aim is to compile the coherently document research on the phytochemical, pharmacological, and biological activities of P. hydropiper from different parts of the globe.

scholarly journals Prevalence of Musculoskeletal Disorders among Dentists in Al-Madinah, Kingdom of Saudi Arabia

2017 ◽  
Vol 03 (01) ◽  
pp. 015-019
Author(s):  
Talat Al-Gunaid ◽  
Rayan Abdulhai ◽  
Baha Flemban
Keyword(s):  
Saudi Arabia ◽  
Musculoskeletal Disorders ◽  
Dental Students ◽  
The Body ◽  
Musculoskeletal Symptoms ◽  
Kingdom Of Saudi Arabia ◽  
Increased Risk ◽  
Dental Practitioners ◽  
Wide Range ◽  
Different Parts

Abstract Introduction: Musculoskeletal disorders (MSDs) are one of the most common occupational hazards associated with a wide range of occupations. Dental professionals have an increased risk of developing such disorders caused by repetitive, hard, or stressful gestures. Taking this issue into consideration, we felt the necessity to investigate the prevalence and distribution of musculoskeletal symptoms among dentists in Al-Madinah. Materials and methods: A self-reported questionnaire was distributed to a random sample of 180 dentists from different parts of Al-Madinah, Kingdom of Saudi Arabia. The questionnaire was about musculoskeletal symptoms in different parts of the body. Results: A total of 70 questionnaires were completed and returned. Of the respondents, 47 (67.1%) were males and 23 (32.9%) were females. The mean age of respondents was 36.1 ± 8.7. Majority were general dental practitioners [45 (64.2%)], with the remainder being specialists [25 (35.8%)]. Prevalence of MSD during the past 12 months was reported to be lower back pain (65.7%), neck pain (48.6%), and shoulder pain (45.7%), with the lowest prevalence pain being found in the hips and thighs (17.1%). Conclusion: The results suggested that the prevalence of musculoskeletal symptoms among dentists in Al-Madinah, Kingdom of Saudi Arabia, is high. Continuing education for dentists and dental students about the proper and correct dental positions as well as practicing ergonomic skills and incorporating them into the curriculum would be beneficial.

scholarly journals Cell-free genetic devices confer autonomic and adaptive properties to hydrogels

2019 ◽  
Author(s):  
Colette J. Whitfield ◽  
Alice M. Banks ◽  
Gema Dura ◽  
John Love ◽  
Jonathan E. Fieldsend ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Information Processing ◽  
Synthetic Biology ◽  
Smart Materials ◽  
Living Organism ◽  
Chemical Diversity ◽  
Biological Information ◽  
Self Healing ◽  
Wide Range

AbstractSmart materials are able to alter one or more of their properties in response to defined stimuli. Our ability to design and create such materials, however, does not match the diversity and specificity of responses seen within the biological domain. We propose that relocation of molecular phenomena from living cells into hydrogels can be used to confer smart functionality to materials. We establish that cell-free protein synthesis can be conducted in agarose hydrogels, that gene expression occurs throughout the material and that co-expression of genes is possible. We demonstrate that gene expression can be controlled transcriptionally (using in gel gene interactions) and translationally in response to small molecule and nucleic acid triggers. We use this system to design and build a genetic device that can alter the structural property of its chassis material in response to exogenous stimuli. Importantly, we establish that a wide range of hydrogels are appropriate chassis for cell-free synthetic biology, meaning a designer may alter both the genetic and hydrogel components according to the requirements of a given application. We probe the relationship between the physical structure of the gel and in gel protein synthesis and reveal that the material itself may act as a macromolecular crowder enhancing protein synthesis. Given the extensive range of genetically encoded information processing networks in the living kingdom and the structural and chemical diversity of hydrogels, this work establishes a model by which cell-free synthetic biology can be used to create autonomic and adaptive materials.Significance statementSmart materials have the ability to change one or more of their properties (e.g. structure, shape or function) in response to specific triggers. They have applications ranging from light-sensitive sunglasses and drug delivery systems to shape-memory alloys and self-healing coatings. The ability to programme such materials, however, is basic compared to the ability of a living organism to observe, understand and respond to its environment. Here we demonstrate the relocation of biological information processing systems from cells to materials. We achieved this by operating small, programmable genetic devices outside the confines of a living cell and inside hydrogel matrices. These results establish a method for developing materials functionally enhanced with molecular machinery from biological systems.

Occurrence and Significance of Toxic Cyanobacteria in Southern Africa

1991 ◽  
Vol 23 (1-3) ◽  
pp. 175-180 ◽  
Author(s):  
W. E. Scott
Keyword(s):  
South Africa ◽  
Southern Africa ◽  
Single Species ◽  
Practical Significance ◽  
Toxic Species ◽  
Toxic Cyanobacteria ◽  
Cyanobacterial Species ◽  
Wide Range ◽  
Toxic Blooms ◽  
Different Parts

A comprehensive list is provided of more than forty cyanobacterial species and genera reported to have toxic properties. In South Africa the majority of animal poisonings since 1927 have been caused by a single species Microcystis aeruginosa. Although other toxic species also occur in southern Africa, to date they have been of little practical significance. The widespread distribution of M. aeruginosa throughout southern Africa indicates a tremendous potential for toxic blooms to develop with increasing eutrophication. Using HPLC techniques up to six different toxin variants have been quantified in natural blooms of M. aeruginosa collected in different parts of South Africa. The amounts and proportions of the different toxins in the different samples varied over a wide range. Several additional unidentified toxins were detected.

RECOGNITION OF PERSIAN ONLINE HANDWRITING USING ELASTIC FUZZY PATTERN RECOGNITION

2007 ◽  
Vol 21 (03) ◽  
pp. 491-513 ◽  
Author(s):  
RAMIN HALAVATI ◽  
SAEED BAGHERI SHOURAKI
Keyword(s):  
Linguistic Terms ◽  
Input Stream ◽  
Cursive Handwriting ◽  
Novel Approach ◽  
Wide Range ◽  
Fuzzy Pattern ◽  
School Books ◽  
Fuzzy Linguistic ◽  
Online Handwriting ◽  
Different Parts

Persian is a fully cursive handwriting in which each character may take different forms in different parts of the word, characters overlap and there is a wide range of possible styles. These complexities make automatic recognition of Persian a very hard task. This paper presents a novel approach on recognition of such writings systems which is based on the description of input stream by a sequence of fuzzy linguistic terms; representation of character patterns with the same descriptive language; and comparison of inputs with character patterns using a novel elastic pattern matching approach. As there is no general benchmark for recognition of Persian handwriting, the approach has been tested on the set of words in first primary Iranian school books including 1250 words resulting in 78% correct recognition without dictionary and 96% with dictionary.

The Physiology of Excretion in the Cotton Stainer, Dysdercus Fasciatus, Signoret

1966 ◽  
Vol 44 (3) ◽  
pp. 553-566
Author(s):  
M. J. BERRIDGE
Keyword(s):  
Osmotic Pressure ◽  
Urine Flow ◽  
Malpighian Tubules ◽  
Hormone Concentration ◽  
Serum Dilution ◽  
Wide Range ◽  
Tentative Hypothesis ◽  
Cotton Stainer ◽  
Urine Formation ◽  
Different Parts

1. The preparation of isolated Malpighian tubules is described. The rate of urine flow increases with increasing serum dilution, and vice versa. Urine is almost isotonic with haemolymph over a wide range of osmotic pressure. 2. Serum collected from 3-day-old insects promotes urine formation, whereas that from 6-day-old insects does not. 3. A factor which was extracted from the m.n.c. accelerates the rate of urine flow, from a normal value of 0·87 to 3·1 mm.3 x 10- 3/min. The osmotic pressure of the urine, however, remains unchanged. 4. The hormone concentration of different parts of the nervous system was assayed with these isolated tubules. Most activity occurs in the m.n.c., but some activity is present in extracts from the c.c. and the fused ganglionic mass in the mesothorax. 5. Malpighian tubules isolated from 6-day-old insects remain inactive, but after the addition of hormone they immediately begin to produce urine. 6. These observations have been incorporated into a tentative hypothesis on the control of excretion in Dysdercus.

scholarly journals Wild Edible Plants Used by Endangered & Indigenous Raji Tribe in Western Nepal

2014 ◽  
Vol 2 (3) ◽  
pp. 243-252 ◽  
Author(s):  
Lal B Thapa ◽  
Til Maya Dhakal ◽  
Raghunath Chaudhary
Keyword(s):  
Indigenous People ◽  
Mother Tongue ◽  
Wild Edible Plants ◽  
Wild Plants ◽  
Traditional Practices ◽  
Edible Plants ◽  
Wild Edible Plant ◽  
Edible Plant ◽  
Beliefs And Practices ◽  
Different Parts

The Rajis are one of the endangered indigenous people distributed in western part of Nepal enriched in their own mother tongue, culture, beliefs and practices. Owing to lack of proper documentation, the traditional knowledge of uses and practices on wild edible plants by such an endangered community is about to extinct. This paper aims to present the traditional practices and use of wild edible plants by Raji people in Nepal. Our study found that a total of 67 wild edible plant species included in 56 genera and 38 families used by Raji people. Out of them 62 species were angiosperms, one species was Gymnosperm and 4 species were Pteridophytes. The results of study show that Rajis have their traditional way to use different parts of wild plants such as seeds, fruits, leaves, shoots, roots and tubers in the forms of vegetables, pickles, juice, and raw or as fruits.DOI: http://dx.doi.org/10.3126/ijasbt.v2i3.10969 Int J Appl Sci Biotechnol, Vol. 2(3): 243-252   

scholarly journals Long-period variables and carbon stars in the Galactic Bulge

1993 ◽  
Vol 153 ◽  
pp. 39-56 ◽  
Author(s):  
Patricia Whitelock
Keyword(s):  
Globular Clusters ◽  
Galactic Bulge ◽  
Carbon Stars ◽  
Instability Strip ◽  
Long Period ◽  
Wide Range ◽  
Evolutionary Phase ◽  
Binary Evolution ◽  
M Stars ◽  
Different Parts

The review covers the properties of red variables in globular clusters and the Galactic Bulge. Details are given of our current understanding of the Mira evolutionary phase. There is evidence that Miras in the LMC and the Bulge occupy different parts of the instability strip but obey the same PLC relation. The Bulge contains at least 2 × 104 Miras of which 100 or so have luminosities in excess of Mbol = — 5 mag. The Mira phase lasts more than 105 yr. These objects originate from stars with a wide range of metallicity, but it is currently unclear if the most metal-rich stars reach the top of the AGB to become Miras. Preliminary data suggest that the distribution of the Miras along the minor axis of the Bulge is different from that of the late-M stars but similar to the 2.4 μm luminosity.Our knowledge of the Bulge carbon stars is briefly reviewed. It is suggested that, by analogy with the carbon-rich dwarfs, these stars are probably best understood as the products of binary evolution.

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