Ergothioneine exhibits longevity-extension effect in Drosophila Melanogaster via regulating of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

2021 ◽  
Author(s):  
Hong-Yu Pan ◽  
Zhiwei Ye ◽  
Qianwang Zheng ◽  
Fan Yun ◽  
Ming-Zhen Tu ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Fatty Acid ◽  
Protective Effect ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Cholinergic Neurotransmission ◽  
Single Study ◽  
Tyrosine Metabolism ◽  
Sulfur Containing ◽  
Extension Effect

Many studies have demonstrated the protective effect of ergothioneine (EGT), the unique sulfur-containing antioxidant in mushrooms, on several aging-related diseases. Nevertheless, to date, no single study has explored the potential...

scholarly journals Random Forest Analysis of Untargeted Metabolomics Data Suggests Increased Use of Omega Fatty Acid Oxidation Pathway in Drosophila Melanogaster Larvae Fed a Medium Chain Fatty Acid Rich High-Fat Diet

Metabolites ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 5 ◽  
Author(s):  
Vishal Oza ◽  
Joseph Aicher ◽  
Laura Reed
Keyword(s):  
Drosophila Melanogaster ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
High Fat Diet ◽  
Untargeted Metabolomics ◽  
Acid Oxidation ◽  
High Fat ◽  
Oxidation Pathway ◽  
Drosophila Larvae ◽  
Omega Fatty Acid

Obesity is a complex disease, shaped by both genetic and environmental factors such as diet. In this study, we use untargeted metabolomics and Drosophila melanogaster to model how diet and genotype shape the metabolome of obese phenotypes. We used 16 distinct outbred genotypes of Drosophila larvae raised on normal (ND) and high-fat (HFD) diets, to produce three distinct phenotypic classes; genotypes that stored more triglycerides on a ND relative to the HFD, genotypes that stored more triglycerides on a HFD relative to ND, and genotypes that showed no change in triglyceride storage on either of the two diets. Using untargeted metabolomics we characterized 350 metabolites: 270 with definitive chemical IDs and 80 that were chemically unidentified. Using random forests, we determined metabolites that were important in discriminating between the HFD and ND larvae as well as between the triglyceride phenotypic classes. We found that flies fed on a HFD showed evidence of an increased use of omega fatty acid oxidation pathway, an alternative to the more commonly used beta fatty acid oxidation pathway. Additionally, we observed no correlation between the triglyceride storage phenotype and free fatty acid levels (laurate, caprate, caprylate, caproate), indicating that the distinct metabolic profile of fatty acids in high-fat diet fed Drosophila larvae does not propagate into triglyceride storage differences. However, dipeptides did show moderate differences between the phenotypic classes. We fit Gaussian graphical models (GGMs) of the metabolic profiles for HFD and ND flies to characterize changes in metabolic network structure between the two diets, finding the HFD to have a greater number of edges indicating that metabolome varies more across samples on a HFD. Taken together, these results show that, in the context of obesity, metabolomic profiles under distinct dietary conditions may not be reliable predictors of phenotypic outcomes in a genetically diverse population.

Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

2019 ◽  
Author(s):  
Helena Urquijo ◽  
Emma N Panting ◽  
Roderick N Carter ◽  
Emma J Agnew ◽  
Caitlin S Wyrwoll ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Fetal Heart ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid

Recognition and management of fatty acid oxidation defects: A series of 107 patients

1999 ◽  
Vol 22 (4) ◽  
pp. 487-502 ◽  
Author(s):  
J. M. Saudubray ◽  
D. Martin ◽  
P. De Lonlay ◽  
G. Touati ◽  
F. Poggi-Travert ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation
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