Indentification of Mitochondria-related Hub Genes in Sarcopenia and Functional Regulation of MFG-E8 on ROS-mediated Mitochondrial Dysfunction and Cell Cycle Arrest

2021 ◽  
Author(s):  
He Li ◽  
Guan Kaifang ◽  
Dandan Liu ◽  
Min Liu
Keyword(s):  
Milk Fat ◽  
Elderly Population ◽  
The Elderly ◽  
Hub Genes ◽  
Cycle Arrest ◽  
High Prevalence ◽  
Milk Fat Globule ◽  
Functional Regulation ◽  
Epidermal Growth ◽  
Fat Globule

Sarcopenia has a high prevalence in the elderly population, but the genes and pathways related to aging in elderly patients with sarcopenia are poorly understood. Milk fat globule epidermal growth...

Loss of milk fat globule-epidermal growth factor 8 (MFG-E8) in mice leads to low bone mass and accelerates ovariectomy-associated bone loss by increasing osteoclastogenesis

Bone ◽  
2015 ◽  
Vol 76 ◽  
pp. 107-114 ◽  
Author(s):  
Kathrin Sinningen ◽  
Elise Albus ◽  
Sylvia Thiele ◽  
Sylvia Grossklaus ◽  
Thomas Kurth ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Bone Loss ◽  
Bone Mass ◽  
Milk Fat ◽  
Low Bone Mass ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule

scholarly journals Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury

2017 ◽  
Vol 213 ◽  
pp. 281-289 ◽  
Author(s):  
Cindy Cen ◽  
Monowar Aziz ◽  
Weng-Lang Yang ◽  
Mian Zhou ◽  
Jeffrey M. Nicastro ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Factor Viii ◽  
Milk Fat ◽  
Kidney Injury ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule

scholarly journals TGF-β Increases MFGE8 Production in Myeloid-Derived Suppressor Cells to Promote B16F10 Melanoma Metastasis

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 896
Author(s):  
Heejin Lim ◽  
Taewoo Yang ◽  
Wongeun Lee ◽  
Sung-Gyoo Park
Keyword(s):  
Milk Fat ◽  
Tumor Metastasis ◽  
Suppressor Cells ◽  
Melanoma Metastasis ◽  
Myeloid Derived Suppressor Cells ◽  
B16f10 Melanoma ◽  
B16f10 Cell ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule

There is growing evidence that myeloid-derived suppressor cells (MDSCs) are directly involved in all stages leading to metastasis. Many mechanisms for this effect have been proposed, but mechanisms of coregulation between tumor cells and MDSCs remain poorly understood. In this study, we demonstrate that MDSCs are a source of milk fat globule-epidermal growth factor (EGF) factor 8 (MFGE8), which is known to be involved in tumor metastasis. Interestingly, TGF-β, an abundant cytokine in the tumor microenvironment (TME), increased MFGE8 production by MDSCs. In addition, co-culturing MDSCs with B16F10 melanoma cells increased B16F10 cell migration, while MFGE8 neutralization decreased their migration. Taken together, these findings suggest that MFGE8 is an important effector molecule through which MDSCs promote tumor metastasis, and the TME positively regulates MFGE8 production by MDSCs through TGF-β.

Milk fat globule epidermal growth factor 8 (MFG-E8): A novel protein in the mammalian endometrium with putative roles in implantation and placentation

Placenta ◽  
2012 ◽  
Vol 33 (10) ◽  
pp. 795-802 ◽  
Author(s):  
S.M. Bocca ◽  
S. Anderson ◽  
B. Amaker ◽  
R.J. Swanson ◽  
A. Franchi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Milk Fat ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule ◽  
Novel Protein

scholarly journals Role of milk fat globule-epidermal growth factor 8 in osteoimmunology

2016 ◽  
Vol 5 ◽  
Author(s):  
Kathrin Sinningen ◽  
Sylvia Thiele ◽  
Lorenz C Hofbauer ◽  
Martina Rauner
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Milk Fat ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule

Milk Fat Globule–Epidermal Growth Factor–Factor 8 Improves Hepatic Steatosis and Inflammation

Hepatology ◽  
2020 ◽  
Author(s):  
Lei Zhang ◽  
Ruifeng Tian ◽  
Xinxin Yao ◽  
Xiao‐Jing Zhang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepatic Steatosis ◽  
Milk Fat ◽  
Milk Fat Globule ◽  
Epidermal Growth ◽  
Fat Globule
Sign in / Sign up

Export Citation Format

Share Document