Prebiotic Agrocybe cylindracea crude polysaccharides combined with Lactobacillus rhamnosus GG postpone aging-related oxidative stress in mice

2022 ◽  
Author(s):  
Li-Xiu Wu ◽  
Xiaoyan Liu ◽  
Rong-Kang Hu ◽  
Yi-Xuan Chen ◽  
Meifang Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lactobacillus Rhamnosus ◽  
Mice Model ◽  
Lactobacillus Rhamnosus Gg ◽  
Agrocybe Cylindracea ◽  
Aging Mechanisms

This study aimed to investigate the potential anti-aging mechanisms of Agrocybe cylindracea crude polysaccharides (APS), when used synergistically with Lactobacillus rhamnosus GG (APS+LGG) in a d-galactose-induced aging mice model. In...

scholarly journals Protective Effect of Lactobacillus rhamnosus GG on TiO2 Nanoparticles-Induced Oxidative Stress Damage in the Liver of Young Rats

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 803
Author(s):  
Penghui Nie ◽  
Mengqi Wang ◽  
Yu Zhao ◽  
Shanji Liu ◽  
Ling Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Toxicity ◽  
Titanium Dioxide Nanoparticles ◽  
Lactobacillus Rhamnosus ◽  
Oral Intake ◽  
Protective Effects ◽  
Lactobacillus Rhamnosus Gg ◽  
Tio2 Nps ◽  
Young Rats ◽  
Hematological Indicators

The potential toxicity of titanium dioxide nanoparticles (TiO2 NPs) to mammals has become a widespread concern. Young individuals exposed to TiO2 NPs have a higher risk than adults. In this study, the protective effects of Lactobacillus rhamnosus GG (LGG) on liver toxicity in young rats induced by TiO2 NPs were explored. Results show that the four-week-old rats that underwent LGG after the oral intake of TiO2 NPs could prevent weight loss, reduce hematological indicators (WBC and NEUT) and serum biochemical indicators (AST, ALT, AST/ALT, and ALP). Moreover, it alleviated the pathological damage of the liver (as indicated by the disordered hepatocytes, more eosinophilic, ballooning degeneration, and accompany with blood cells), but it did not reduce the Ti contents in the liver. In addition, RT-qPCR results indicated that LGG restored the expression of anti-oxidative stress-related genes, such as SOD1, SOD2, CAT, HO-1, GSH, GCLC, and GCLM in the liver. In summary, the hepatotoxicity of TiO2 NPs in young rats is closely related to oxidative stress, and the antioxidant effect of LGG might protect the harmful effects caused by TiO2 NPs.

scholarly journals Lactobacillus rhamnosus GG orchestrates an anti-tumor immune response

2021 ◽  
Author(s):  
Joshua A. Owens ◽  
Bejan J. Saeedi ◽  
Crystal R. Naudin ◽  
Sarah Hunter-Chang ◽  
Maria E. Barbian ◽  
...  
Keyword(s):  
Immune Response ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg
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