Oxyresveratrol Inhibits Human Colon Cancer Cell Migration through Regulating Epithelial-Mesenchymal Transition and MicroRNA

2021 ◽  
Author(s):  
Ting-Ann Lin ◽  
Wei-Sheng Lin ◽  
Ya-Chun Chou ◽  
Nagabhushanam Kalyanam ◽  
Chi-Tang Ho ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cell Migration ◽  
Epithelial Mesenchymal Transition ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Cancer Cell Migration ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Mesenchymal Transition

The major cause of death in Colorectal cancer (CRC) patients is metastasis. Moreover, lots of studies have emphasized that the epithelial-mesenchymal transition (EMT) is a pivotal step in metastasis. Both...

scholarly journals Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc 1638N mice

2013 ◽  
Vol 34 (11) ◽  
pp. 2629-2638 ◽  
Author(s):  
Elvira R.M. Bakker ◽  
Asha Mooppilmadham Das ◽  
Werner Helvensteijn ◽  
Patrick F. Franken ◽  
Sigrid Swagemakers ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Intestinal Tumorigenesis

scholarly journals Anoxia/reoxygenation induces epithelial-mesenchymal transition in human colon cancer cell lines

2013 ◽  
Vol 29 (6) ◽  
pp. 2311-2317 ◽  
Author(s):  
MANABU OKAJIMA ◽  
SATOSHI KOKURA ◽  
TAKESHI ISHIKAWA ◽  
KATSURA MIZUSHIMA ◽  
REIKO TSUCHIYA ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Mesenchymal Transition ◽  
Colon Cancer Cell Lines

scholarly journals Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Jung-Yu Kan ◽  
Ya-Ling Hsu ◽  
Yen-Hsu Chen ◽  
Tun-Chieh Chen ◽  
Jaw-Yuan Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Nuclear Translocation ◽  
Epithelial Mesenchymal Transition ◽  
Human Colon ◽  
Inhibitory Effect ◽  
Migration And Invasion ◽  
Human Colon Cancer ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion

Gemifloxacin (GMF) is an orally administered broad-spectrum fluoroquinolone antimicrobial agent used to treat acute bacterial exacerbation of pneumonia and bronchitis. Although fluoroquinolone antibiotics have also been found to have anti-inflammatory and anticancer effects, studies on the effect of GMF on treating colon cancer have been relatively rare. To the best of our knowledge, this is the first report to describe the antimetastasis activities of GMF in colon cancer and the possible mechanisms involved. Results have shown that GMF inhibits the migration and invasion of colon cancer SW620 and LoVo cells and causes epithelial mesenchymal transition (EMT). In addition, GMF suppresses the activation of NF-κB and cell migration and invasion induced by TNF-αand inhibits the TAK1/TAB2 interaction, resulting in decreased IκB phosphorylation and NF-κB nuclear translocation in SW620 cells. Furthermore, Snail, a critical transcriptional factor of EMT, was downregulated after GMF treatment. Overexpression of Snail by cDNA transfection significantly decreases the inhibitory effect of GMF on EMT and cell migration and invasion. In conclusion, GMF may be a novel anticancer agent for the treatment of metastasis in colon cancer.

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