Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mice model via SIRT3-induced synaptic plasticity

2021 ◽  
Author(s):  
Hongyan Lu ◽  
Li Fang ◽  
Ji Wang ◽  
Fanrui Zhao ◽  
Chunlei Liu ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Memory Impairment ◽  
Mice Model ◽  
Antioxidant Peptides ◽  
Short Peptide ◽  
Pine Nut ◽  
Peptide Derivative

This study aimed to investigate the effects of a pine nut albumin hydrolysate (fraction < 3 kDa) and of its short peptide derivative, Trp-Tyr-Pro-Gly-Lys (WYPGK), on synaptic plasticity and memory...

P1-159: Truncated tau transgenic mice model showing memory impairment in early age

2010 ◽  
Vol 6 ◽  
pp. S220-S220
Author(s):  
YoungDoo Kim ◽  
Hyun Woo Choi ◽  
Hyejin Park ◽  
Yong-Keun Jung
Keyword(s):  
Transgenic Mice ◽  
Memory Impairment ◽  
Early Age ◽  
Mice Model

P.1.j.018 Deletion of cannabinoid-2 receptors induces memory impairment associated with synaptic plasticity alterations

2013 ◽  
Vol 23 ◽  
pp. S291-S292
Author(s):  
M. García-Gutiérrez ◽  
A. Ortega-Alvaro ◽  
A. Busquets ◽  
J.M. Péirez-Ortiz ◽  
L. Caltana ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Memory Impairment

Corrigendum to “Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease” [Behav. Brain Res. 374 (2019) 112106]

2020 ◽  
Vol 377 ◽  
pp. 112222
Author(s):  
Verónica Espinosa-Fernández ◽  
Aroa Mañas-Ojeda ◽  
Mar Pacheco-Herrero ◽  
Ernestina Castro-Salazar ◽  
Francisco Ros-Bernal ◽  
...  
Keyword(s):  
Early Intervention ◽  
Transgenic Mice ◽  
Memory Impairment ◽  
Mice Model

Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment

2020 ◽  
Vol 79 ◽  
pp. 200-208 ◽  
Author(s):  
Masoomeh Nazifi ◽  
Manoochehr Ashrafpoor ◽  
Shahrbanoo Oryan ◽  
Delaram Eslimi Esfahani ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Rat Model ◽  
Memory Impairment ◽  
High Dose ◽  
Neurotoxic Effects

Changes in hippocampal spine morphology and synaptic plasticity induced by conditional loss of PDGFR-β are associated with memory impairment in mutant mice

2009 ◽  
Vol 65 ◽  
pp. S67 ◽  
Author(s):  
Norifumi Shioda ◽  
Shigeki Moriguchi ◽  
Yui Yamamoto ◽  
Takako Matsushima ◽  
Masakiyo Sasahara ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Memory Impairment ◽  
Mutant Mice ◽  
Spine Morphology ◽  
With Memory

Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment

2015 ◽  
Vol 134 (4) ◽  
pp. 642-651 ◽  
Author(s):  
Padmanabh Singh ◽  
Arpita Konar ◽  
Ashish Kumar ◽  
Sweta Srivas ◽  
Mahendra K. Thakur
Keyword(s):  
Gene Expression ◽  
Synaptic Plasticity ◽  
Memory Impairment

scholarly journals Poly (I:C) Exposure in Early Life Alters Methylation of DNA and Acetylation of Histone at Synaptic Plasticity Gene Promoter in Developing Rat Brain Leading to Memory Impairment

2019 ◽  
Vol 26 (3-4) ◽  
pp. 35-41
Author(s):  
Meghraj Singh Baghel ◽  
Brijendra Singh ◽  
Nisha Patro ◽  
Vinay Kumar Khanna ◽  
Ishan Kumar Patro ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Early Life ◽  
Memory Impairment ◽  
Viral Infections ◽  
Gene Promoter ◽  
Later Life ◽  
Poly I:C ◽  
Normal Brain ◽  
Gene Promoters ◽  
Methylation Of Dna

Background: Exposure to adverse environmental conditions such as toxic chemicals, viral infections, and even stress during pregnancy or early life may disrupt the development of normal brain and its functioning leading to incidence of neurodevelopmental disorders at later stages of life. Recently, we reported that poly (I:C) exposure altered synaptic plasticity protein level and impaired memory through activation of microglia cells. Purpose: As epigenetic modifications are involved in memory formation, we have studied methylation of DNA and acetylation of histone at promoters of synaptic plasticity genes in the brain of rats exposed to poly (I:C) during early life. Methods: One dose of poly (I:C) (5 mg/kg bw) was intraperitoneally injected to rat pups on postnatal seventh day. A set of pups exposed to vehicle was included as control. In order to assess methylation of DNA and acetylation of histone at synaptic plasticity gene promoter, we performed qPCR after methylated DNA immunoprecipitation and chromatin immunoprecipitation. Results: Poly (I:C) exposure reduced the level of 5-methylcytosine (5mC) at synaptic plasticity gene ( bdnf, arc, and egr1) promoters in the frontal cortex (FC) and hippocampus of 3-week rats, although increased it later in both regions of 12-week rats as compared to respective controls. On contrary, poly (I:C) exposure enhanced acetylation of histone H3K9 (H3K9Ac) at promoters of these genes in both regions of 3-week rats but decreased in 12-week rats. Conclusion: Poly (I:C) exposure altered 5mC and H3K9Ac at synaptic plasticity gene promoters resulting in memory impairment of rats at later life.

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