Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib

2021 ◽  
Author(s):  
Ali Bagherian ◽  
Bostan Roudi ◽  
Nahid Masoudian ◽  
Hamed Mirzaei
Keyword(s):  
Brain Neoplasms

Glioblastoma (GBM), one of the most significant brain neoplasms, is characterized by high metastasis and recurrence.

Role of susceptibility weighted imaging (SWI) in assessment of intra axial brain neoplasms in adults

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Pasant Mohamed Abo-Elhoda Darwish Mohamed Abo-Elhoda ◽  
Hesham Mahmoud Ahmed Mansour ◽  
Yosra Abdelzaher Abdullah ◽  
Eman Ahmed Fouad Darwish
Keyword(s):  
Brain Neoplasms ◽  
Tumor Size ◽  
Venous Blood ◽  
Brain Parenchyma ◽  
P Value ◽  
Susceptibility Weighted Imaging ◽  
Low Grade ◽  
Chi Square ◽  
Cross Sectional

Abstract Background Susceptibility weighted imaging (SWI) is a 3D gradient-echo MR technique that is based on blood oxygen level dependent (BOLD) induced phase effects between the venous blood and the surrounding brain parenchyma. SW-MR imaging allows for noninvasive visualization of small veins at submillimeter resolution and, therefore, is used to depict venous architecture in brain lesions. The extreme sensitivity of SWI for the detection of neovascularity (venous blood), haemorrhage, and calcification has been an indispensable tool for characterization of the internal architecture of brain tumours. Objectives Is to evaluate the role of Susceptibility weighted imaging in assessment of adults Intra axial brain Neoplasms, and its ability to characterize them into high and low grade lesions in comparison to histopathology which will be used as gold standard. Methods A cross sectional study including 31 patients suspecting intracranial brain neoplasm radiologically and clinically, conducted at Private center, the patients were investigated using Siemens machine Magnetom Skyra 3T, the period was between January 2018 till the end of June 2019 . Results Our study included 31 patients. Including 15 female and 16 male patients, with the patient’s age ranging from 20 to 68 years old with median 48 years old ranging from 35.75 (25% percentile) to 58.75 (75% percentile). Among total cases, there were 8 patients with grade 2 glioma, 10 patients with grade 3 glioma and 6 patients with grade 4 glioma, 2 patients with lymphoma and 5 patients with brain metastasis (1 lung cancer and 4 breast cancer). All the patients were evaluated with MRI including SWI sequence with special comment on the number of the intratumoral susceptibility signal (ITSS), the size of the ITSS, its morphology as well as the ratio of the ITSS to the tumor size, which were then correlated with the patient histopathological results obtained later. The study revealed that the best parameter to accurately grade the tumor is the number of ITSS within the lesion with P value 0.001, followed by the size of the ITSS with P value 0.002 and Pearson Chi-Square value equals 20.6, while the lowest one was the ratio of the ITSS to the tumor size with P value 0.002 Pearson Chi-Square value equals 17.3. Our study showed that the morphology alone was not able to accurately grade the tumor with P value 0.007 ( Not significant) Conclusion SWI using 3T MR system provides quite useful information for preoperative tumor grading. There seems to be a strong correlation between pathological grading and that assessed with SWI.

Migration and invasion in brain neoplasms

2001 ◽  
Vol 1 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Anna J. Bolteus ◽  
Michael E. Berens ◽  
Geoffrey J. Pilkington
Keyword(s):  
Brain Neoplasms ◽  
Migration And Invasion

Brain neoplasms: epidemiology, diagnosis, and prospects for cost-effective imaging

2003 ◽  
Vol 13 (2) ◽  
pp. 237-250 ◽  
Author(s):  
Alf Hutter ◽  
Katherine E Schwetye ◽  
Andrew J Bierhals ◽  
Robert C McKinstry
Keyword(s):  
Brain Neoplasms ◽  
Cost Effective

scholarly journals Epidemiological Profile of Malignant Brain Neoplasms in the Northern Region of Brazil: data from the Cancer Hospital Registry of the Instituto Nacional de Câncer

2017 ◽  
Vol 38 (02) ◽  
pp. 094-101
Author(s):  
Carlos Eduardo Adriano Filho ◽  
Lenon Machado Pinto ◽  
Joel Monteiro de Jesus
Keyword(s):  
Brain Neoplasms ◽  
Age Groups ◽  
Northern Region ◽  
Astrocytic Tumors ◽  
Embryonal Tumors ◽  
Male Predominance ◽  
Cancer Hospital ◽  
Incidence And Mortality ◽  
Epidemiological Profile ◽  
Hospital Registry

Objective Tumors of the central nervous system (CNS) are considered rare, with an incidence of 3.4 cases per 100,000 individuals worldwide. Although uncommon, CNS tumors have been gaining epidemiological importance due to their increased incidence and mortality. In Brazil, there is a lack of population research regarding CNS cancer, especially in the Northern region. Thus, the authors aim to trace an epidemiological profile of malignant brain neoplasms in the Northern region from 2001 to 2013. Methods Data were collected from the Cancer Hospital Registry of the Instituto Nacional de Câncer (RHC-INCA, in the Portuguese acronym) and stratified according to origin, gender, age, detailed primary location, and histological type. A total of 742 cases were analyzed. Most of the cases came from inland areas, with a male predominance. Results The most affected age groups were between 0 and 9 years old and between 30 and 49 years old, with an accentuated decrease in incidence starting at the age of 70 years old. The frontal lobe was the most affected area, followed by the temporal and parietal lobes. Astrocytic tumors accounted for 64.3% of cases, followed by embryonal tumors (18.2%), and ependymal tumors (7.4%). Among the astrocytic tumors, astrocytoma, not otherwise specified (NOS), and glioblastoma, NOS corresponded to 82.2% of the cases. Among embryonal tumors, medulloblastoma accounted for 71.9% of the cases. Conclusion More epidemiological studies in this area, especially in the Northern region, are required to identify risk factors and allow prevention and early diagnosis.

CT and MRI findings in gliomatosis cerebri: a neuroradiologic and neuropathologic review of diffuse infiltrating brain neoplasms

2001 ◽  
Vol 11 (2) ◽  
pp. 309-316 ◽  
Author(s):  
M. Freund ◽  
S. Hähnel ◽  
C. Sommer ◽  
M. Martmann ◽  
M Kiessling ◽  
...  
Keyword(s):  
Brain Neoplasms ◽  
Gliomatosis Cerebri ◽  
Mri Findings ◽  
Ct And Mri

Confocal scanning microscopy provides rapid, detailed intraoperative histological assessment of brain neoplasms: Experience with 106 cases

2018 ◽  
Vol 169 ◽  
pp. 21-28 ◽  
Author(s):  
Nikolay L. Martirosyan ◽  
Joseph Georges ◽  
Jennifer M. Eschbacher ◽  
Evgenii Belykh ◽  
Alessandro Carotenuto ◽  
...  
Keyword(s):  
Brain Neoplasms ◽  
Scanning Microscopy ◽  
Histological Assessment ◽  
Confocal Scanning ◽  
Confocal Scanning Microscopy

SU-FF-I-79: Evaluation of Reproducibility of FMRI Maps in Patients with Proven Low-Grade Brain Neoplasms

2007 ◽  
Vol 34 (6Part3) ◽  
pp. 2356-2356
Author(s):  
R McKinsey ◽  
C Moritz ◽  
G Heredia ◽  
W Tome ◽  
M Meyerand
Keyword(s):  
Brain Neoplasms ◽  
Low Grade
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