scholarly journals BIOACTIVITY SCREENING OF PINHÃO (ARAUCARIA ANGUSTIFOLIA (BERTOL.) KUNTZE) SEEDS EXTRACTS: INHIBITION OF CHOLINESTERASES AND α-AMYLASES, CYTOTOXIC AND ANTI-INFLAMMATORY ACTIVITIES

2021 ◽  
Author(s):  
Anielle de Oliveira ◽  
Thaysa Fernandes Moya Moreira ◽  
Ana Luisa Silva Pepinelli ◽  
Luis Gustavo Medice Arabel Costa ◽  
Luana Eloísa Leal ◽  
...  
Keyword(s):  
Araucaria Angustifolia ◽  
Bioactive Properties ◽  
Anti Inflammatory

The objective of this work was to determine the potential bioactive properties of the extracts from the bio-residues of pinhão (Araucaria angustifolia (Bertol.) Kuntze) seeds, namely to α-amylases and cholinesterases...

scholarly journals Glycemic Response and Bioactive Properties of Gluten-Free Bread with Yoghurt or Curd-Cheese Addition

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1410
Author(s):  
Carla Graça ◽  
Joana Mota ◽  
Ana Lima ◽  
Ricardo Boavida Ferreira ◽  
Anabela Raymundo ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Glycemic Index ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Total Phenolic ◽  
Glycemic Response ◽  
Gluten Free ◽  
Antioxidant Power ◽  
Bioactive Properties ◽  
Anti Inflammatory

The influence of flour replacement by yogurt or curd-cheese additions (from 10% to 20%, w/w) on the glycemic response and bioactivity improvements of gluten-free bread was evaluated. Starch digestibility, measured by an in vitro digestion model, was applied to determine the effect on starch fractions. The bread glycemic index was calculated. Bread antioxidant capacity (2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric-ion-reducing antioxidant power (FRAP) methods) and total phenolic compounds were assessed. Anti-inflammatory properties according to enzymatic matrix metalloproteinase (MMP)-9 inhibitory activity were also studied. Considering the higher level of both dairy products tested (20%, w/w) and comparing with control bread results, a reduction of around 35% in the glycemic response of curd cheese bread was achieved, resulting in intermediate index level (glycemic index (GI) 55–69), with yogurt bread still showing a high glycemic index (GI > 70). In terms of bread bioactivity, curd cheese bread expressed better reducing power effects, whereas yogurt bread showed more effective radical-scavenging capacity. An increase in bread phenolic compounds by yogurt (55.3%) and curd cheese (73.0%) additions (at 20%) were also registered. MMP-9 inhibition activity was higher in the dairy bread than in control bread, suggesting an improvement in terms of anti-inflammatory properties. The supplementation of the gluten-free bread by yogurt or curd cheese was shown to be a promising strategy to reduce the glycemic response and to improve the bioactive properties of the bread, that which can contribute to preventive diets of celiac patients and irritable bowel syndrome individuals.

scholarly journals Phytochemical Characterization and Bioactive Properties of Cinnamon Basil (Ocimum basilicum cv. ‘Cinnamon’) and Lemon Basil (Ocimum × citriodorum)

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 369 ◽  
Author(s):  
Chaimae Majdi ◽  
Carla Pereira ◽  
Maria Inês Dias ◽  
Ricardo C. Calhelha ◽  
Maria José Alves ◽  
...  
Keyword(s):  
Thiobarbituric Acid ◽  
Positive Control ◽  
Thiobarbituric Acid Reactive Substances ◽  
Oxidative Hemolysis ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Derivatives Of

The aim of this work was to contribute to the knowledge on the chemical composition and bioactive properties of two species of the Ocimum genus, namely O. basilicum cultivar ’Cinammon’ and O. × citriodorum. For this purpose, samples of these plants grown in Portugal were evaluated for their composition in phenolic and volatile compounds, and the infusion and hydroethanolic extracts were assessed for their in vitro antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities. In total, the two basil samples showed the presence of seven caffeic acid and derivatives (dimers, trimers, and tetramers) and five flavonoids, mainly glycoside derivatives of quercetin. Despite some qualitative and quantitative differences, in both samples rosmarinic acid was the major phenolic compound, and linalool the predominant volatile compound. In general, the tested extracts provided relevant bioactive properties since both basil species showed higher antioxidant activity in Thiobarbituric Acid Reactive Substances (TBARs) and Oxidative Hemolysis Inhibition (OxHLIA) assays when compared with the positive control Trolox. Despite O. × citriodorum extracts showing slightly better activity against some strains, both types of extracts evidenced similar antimicrobial activity, being more active against Gram-positive bacteria. The extracts also revealed interesting cytotoxicity, particularly the O. × citriodorum hydroethanolic extract which was also the only one exhibiting anti-inflammatory activity.

scholarly journals HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of Zizyphus lotus (L.) Desf.

2019 ◽  
Vol 10 (9) ◽  
pp. 5898-5909 ◽  
Author(s):  
Wahiba Rached ◽  
Lillian Barros ◽  
Borhane E. C. Ziani ◽  
Malika Bennaceur ◽  
Ricardo C. Calhelha ◽  
...  
Keyword(s):  
Esi Ms ◽  
Plant Parts ◽  
Antimicrobial Potential ◽  
Bioactive Properties ◽  
Phytochemical Compounds ◽  
Anti Inflammatory

Zizyphus lotus L. (Desf.) presented flavonoids and secoiridoids derivatives and revealed to have cytotoxicity, anti-inflammatory and antimicrobial potential.

Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

2021 ◽  
Vol 21 ◽  
Author(s):  
Xiliang Yang ◽  
Jinping Liu ◽  
Jiahui Mei ◽  
Rui Jiang ◽  
Shizheng Tu ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Drug Development ◽  
Valuable Source ◽  
Chemical Structures ◽  
New Drug ◽  
Bioactive Properties ◽  
Potential Applications ◽  
New Drug Development ◽  
Anti Inflammatory

: In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine-derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

scholarly journals Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1930
Author(s):  
Adriana P. Januário ◽  
Rafael Félix ◽  
Carina Félix ◽  
João Reboleira ◽  
Patrícia Valentão ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Acne Vulgaris ◽  
Treatment Options ◽  
Red Macroalgae ◽  
Bioactive Properties ◽  
Cutibacterium Acnes ◽  
Adolescents And Adults ◽  
Anti Inflammatory ◽  
Chronic Skin ◽  
The 1960S

Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

scholarly journals Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 475
Author(s):  
Beatriz H. Paschoalinotto ◽  
Maria Inês Dias ◽  
José Pinela ◽  
Tânia C.S.P. Pires ◽  
Maria José Alves ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Principal Component ◽  
Biological Properties ◽  
Added Value ◽  
Array Detector ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Fluorescence Detector ◽  
Bioactive Properties ◽  
Anti Inflammatory

The chemical composition and biological properties correlation in several medicinal and aromatic plants is still underexplored, especially in its most common form of consumption as tisane. The present study aims to characterize the organic acids and vitamin E composition of five tisanes and their extracts by High-Performance Liquid Chromatography coupled to a diode-array detector (HPLC-DAD) and HPLC coupled to a fluorescence detector techniques, respectively, and the phenolic composition by HPLC-DAD-ESI/MS (mass spectrometry by electrospray ionization). It also focuses on their bioactive properties, namely antioxidant, antimicrobial, anti-inflammatory, cytotoxic, anti-tyrosinase, and anti-diabetic activities. A Principal Component Analysis (PCA) was performed in order to understand the correlation between the chemical composition and bioactive properties of the tisanes. The tisane 5 (T5) composed by lemon thyme, tutsan, cloves, and cinnamon, was the most promising mixture, presenting the lowest values for the lipid peroxidation inhibition, anti-inflammatory, and anti-diabetic activity. It also presented the highest concentration of phenolic acids (caffeoylquinic acids derivatives), and flavan-3-ols (catechin derivatives). Only the dry plants presented tocopherols. For the antihemolytic, antimicrobial, and cytotoxic activity, T2 and T4 (with lemon thyme) were highlighted as the best herbal mixtures. The PCA proved to be a valid tool to select the most promising tisane according to the bioactivity. These results suggest that the studied tisanes can be source of high added-value bioactive compounds with health-promoting effects and potential for application in the food and nutraceutical industries, among others.

scholarly journals Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC.: An In Vitro Comparative Study between Leaves, Stems, and Flowers

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1696 ◽  
Author(s):  
Souilem ◽  
Dias ◽  
Barros ◽  
Calhelha ◽  
Alves ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Bactericidal Effect ◽  
Antimicrobial Activities ◽  
Added Value ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

The present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa (Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS, correlating them with bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal effect against E. coli, while stems presented a higher cytotoxic activity and bactericidal effect against Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the presence of phenolic compounds was also verified. The obtained results bring added value to the studied plant species

scholarly journals Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia

2021 ◽  
Vol 22 (16) ◽  
pp. 8912
Author(s):  
Sachiko Koyama ◽  
Kenji Kondo ◽  
Rumi Ueha ◽  
Hideki Kashiwadani ◽  
Thomas Heinbockel
Keyword(s):  
Essential Oils ◽  
Chemical Constituents ◽  
Chemical Compounds ◽  
Clinical Settings ◽  
Training Method ◽  
Chemical Senses ◽  
Bioactive Properties ◽  
Olfactory Sense ◽  
Anti Inflammatory

The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms of the SARS-CoV-2 disease, COVID-19, is the loss of chemical senses, i.e., smell and taste. Smell training is one of the methods used in facilitating recovery of the olfactory sense, and it uses essential oils of lemon, rose, clove, and eucalyptus. These essential oils were not selected based on their chemical constituents. Although scientific studies have shown that they improve recovery, there may be better combinations for facilitating recovery. Many phytochemicals have bioactive properties with anti-inflammatory and anti-viral effects. In this review, we describe the chemical compounds with anti- inflammatory and anti-viral effects, and we list the plants that contain these chemical compounds. We expand the review from terpenes to the less volatile flavonoids in order to propose a combination of essential oils and diets that can be used to develop a new taste training method, as there has been no taste training so far. Finally, we discuss the possible use of these in clinical settings.

scholarly journals Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from Distichochlamys benenica

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ty Viet Pham ◽  
Hanh Nhu Thi Hoang ◽  
Hoai Thi Nguyen ◽  
Hien Minh Nguyen ◽  
Cong Thang Huynh ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Coumaric Acid ◽  
Paw Edema ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Bioactive Properties ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Available Information

Distichochlamys benenica is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating trans-o-coumaric acid (1), trans-cinnamic acid (2), and borneol (3) from the rhizomes of D. benenica Q.B.Nguyen & Škorničk and evaluate the anti-inflammatory and antimicrobial activities of 1-3 using the carrageenan paw edema model and the dilution broth method, respectively. This revealed that 1 was as effective as diclofenac in reducing the intensity of the edema development. The in silico research showed that the activity of 1 might be derived from inhibiting COX-2 by generating h-bonds at the positions of Arg 120, Tyr 355, and Arg 513 residues. The antimicrobial activities against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) were comparable, with the minimum inhibitory concentrations ranging from 1.52 to 3.37 mM. This is the first study of the bioactivity of compounds isolated from D. benenica Q.B.Nguyen & Škorničk. Our results suggest that 1 may be a nature-derived compound which demonstrates the anti-inflammatory properties and inhibit the proliferation of several Gram-positive bacteria.

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