scholarly journals Human milk oligosaccharide 2′-fucosyllactose supplementation improves gut barrier function and signaling in the vagal afferent pathway in mice

2021 ◽  
Author(s):  
Sunhye Lee ◽  
Michael L. Goodson ◽  
Wendie Vang ◽  
Jennifer Rutkowsky ◽  
Karen Kalanetra ◽  
...  
Keyword(s):  
Human Milk ◽  
Intestinal Microbiota ◽  
Intestinal Barrier ◽  
Hormone Resistance ◽  
Afferent Pathway ◽  
Milk Oligosaccharide ◽  
Gut Barrier Function ◽  
Gut Hormone ◽  
Human Milk Oligosaccharide ◽  
Vagal Afferent

2’-Fucosyllactose (2’-FL), a predominant human milk oligosaccharide, attenuates HF diet-induced metabolic and intestinal barrier impairment, improves gut hormone resistance, and alters the intestinal microbiota and microbiota-derived metabolites.

scholarly journals Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 790 ◽  
Author(s):  
Ana Lorena Ferreira ◽  
Ronaldo Alves ◽  
Amanda Figueiredo ◽  
Nadya Alves-Santos ◽  
Nathalia Freitas-Costa ◽  
...  
Keyword(s):  
Human Milk ◽  
Rank Correlation ◽  
Postpartum Visit ◽  
Maternal Characteristics ◽  
Milk Oligosaccharide ◽  
Healthy Women ◽  
Human Milk Oligosaccharide ◽  
Post Hoc ◽  
Brazilian Cohort ◽  
Non Negative Matrix Factorization

Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum and explores the influences of maternal sociodemographic and anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28–35 gestational weeks (baseline) and throughout lactation at 2–8 (visit 1), 28–50 (visit 2) and 88–119 days postpartum (visit 3). Milk samples were collected at visits 1, 2 and 3, and 19 HMOs were quantified usinghigh-performance liquid chromatography with fluorescence detection (HPLC-FL). Friedman post-hoc test, Spearman rank correlation for maternal characteristics and HMOs and non-negative matrix factorization (NMF) were used to define the HMO profile. Most women were secretors (89.1%) and presented high proportion of 2′-fucosyllactose (2′FL) at all three sample times, while lacto-N-tetraose (LNT, 2–8 days) and lacto-N-fucopentaose II (LNFPII, 28–50 and 88–119 days) were the most abundant HMOs in non-secretor women. Over the course of lactation, total HMO weight concentrations (g/L) decreased, but total HMO molar concentrations (mmol/L) increased, highlighting differential changes in HMO composition over time. In addition, maternal pre-pregnancy body mass index (BMI) and parity influence the HMO composition in healthy women in this Brazilian cohort.

scholarly journals Human norovirus inhibition by a human milk oligosaccharide

Virology ◽  
2017 ◽  
Vol 508 ◽  
pp. 81-89 ◽  
Author(s):  
Anna Koromyslova ◽  
Shailesh Tripathi ◽  
Vasily Morozov ◽  
Horst Schroten ◽  
Grant S. Hansman
Keyword(s):  
Human Milk ◽  
Human Norovirus ◽  
Milk Oligosaccharide ◽  
Human Milk Oligosaccharide

scholarly journals Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices

2018 ◽  
Vol 148 (11) ◽  
pp. 1733-1742 ◽  
Author(s):  
Meghan B Azad ◽  
Bianca Robertson ◽  
Faisal Atakora ◽  
Allan B Becker ◽  
Padmaja Subbarao ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Human Milk ◽  
Feeding Practices ◽  
Maternal Characteristics ◽  
Milk Oligosaccharide ◽  
Human Milk Oligosaccharide
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