Resveratrol, a novel inhibitor of GLUT9, ameliorates liver and kidney injuries in a d-galactose-induced ageing mouse model via the regulation of uric acid metabolism

2021 ◽  
Author(s):  
Lu Li ◽  
Yongmei Li ◽  
Jian Luo ◽  
Yanqing Jiang ◽  
Ze'an Zhao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Mouse Model ◽  
Acid Metabolism ◽  
Natural Aging ◽  
Liver And Kidney ◽  
Chronic Injection

Accumulating evidence has shown that chronic injection of d-galactose (d-gal) can mimic the natural aging, accompanying with liver and kindey injury. Previous studies have shown that d-gal-induced uric acid (UA)...

Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity

2019 ◽  
Vol 15 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Giovambattista Desideri ◽  
Raffaella Bocale ◽  
Anna Maria D’Amore ◽  
Giulia Carnassale ◽  
Stefano Necozione ◽  
...  
Keyword(s):  
Uric Acid ◽  
Insulin Sensitivity ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Acid Metabolism ◽  
Recent Onset

scholarly journals STUDIES IN URIC ACID METABOLISM

1923 ◽  
Vol 55 (3) ◽  
pp. 373-384
Author(s):  
Howard B. Lewis ◽  
Ralph C. Corley
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

scholarly journals STUDIES IN ENDOGENOUS URIC ACID METABOLISM

1914 ◽  
Vol 19 (4) ◽  
pp. 473-485
Author(s):  
G.W. Raiziss ◽  
H. Dubin ◽  
A.I. Ringer
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

Effect of Riboflavin Deficiency on the Metabolism of Oxypurines in Chicks

1971 ◽  
Vol 49 (12) ◽  
pp. 1059-1062 ◽  
Author(s):  
S. T. Chou
Keyword(s):  
Uric Acid ◽  
Acid Synthesis ◽  
Xanthine Dehydrogenase ◽  
Broiler Chicks ◽  
Uric Acid Concentration ◽  
Riboflavin Deficiency ◽  
Deficient Diet ◽  
High Incidence ◽  
Liver And Kidney ◽  
Riboflavin Deficient

Day-old broiler chicks of both sexes were used in three experiments to determine the effect of riboflavin deficiency on oxypurine metabolism catalyzed by xanthine dehydrogenase, a riboflavin-containing enzyme. Chicks fed a riboflavin-deficient diet (1.38 mg/kg) for 3 weeks exhibited depressed growth and a high incidence of curled-toe paralysis (higher than 80%) as compared to control chicks (15.1 mg riboflavin per kilogram diet; no incidence of curled-toe paralysis). In addition, the precursors of uric acid, hypoxanthine and/or xanthine, accumulated in the liver and kidney of deficient chicks showing curled-toe paralysis. These observations show that dietary riboflavin being incorporated into xanthine dehydrogenase is essential for oxypurine metabolism. Moreover in the chick, the liver and the kidney may be important sites of uric acid synthesis. The low uric acid concentration in the plasma of the deficient chicks appeared to be indicative of a disturbance in uric acid synthesis in the liver and kidney.

Metabolism of the Black Snake Embryo

1953 ◽  
Vol 30 (4) ◽  
pp. 492-501 ◽  
Author(s):  
HUGH CLARK
Keyword(s):  
Energy Source ◽  
Uric Acid ◽  
Acid Synthesis ◽  
K Value ◽  
Embryonic Tissues ◽  
Hatching Time ◽  
Urea Content ◽  
Foetal Liver ◽  
Liver And Kidney ◽  
Post Deposition

1. Post-deposition growth of the black snake embryo is characterized by k values as follows: days 1-11, 0.46; days 11-34, 0.057; days 34-67, 0.039. 2. Total excreted nitrogen is 12.55 mg. occurring successively in development as ammonia, urea and uric acid; k value of total nitrogen production is 0.062, days 11-67, which in comparison with those of growth during this period suggest that stored protein is an energy source during a large part of development. 3. Urea is excreted into the albumen which is the principal storage reservoir and into the yolk; that which is excreted into the yolk is reabsorbed after the 45th day and re-deposited in the albumen as urea, and is in part (22%) converted to uric acid. 4. Concentration of urea in the yolk and yolk-sac continues to increase at the same rate after the 11th day (k = 0.024), although the actual amount declines after the 45th day; concentration in the embryonic tissues increases to the 58th day, then decreases sharply to hatching time; concentration in the albumen increases throughout development, reaching a concentration of approximately 500 mg.%. 5. Uric acid synthesis is believed to be preceded by urea formation, and the presence of urease in the foetal liver and kidney suggest that the urea is hydrolysed to ammonia which is then incorporated into uric acid. Site of the transformation is uncertain, though the early and persistent localization of uric acid in the chorio-allantoic membrane points to this as the organ of synthesis. Decrease in total urea content is quantitatively identical with increase in uric acid. 6. The significance of these findings in relation to development of the vertebrate cleidoic egg is discussed.

Disturbances of Uric Acid Metabolism

1983 ◽  
pp. 155-172
Author(s):  
Edwin Mejías ◽  
Manuel Martínez-Maldonado
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

scholarly journals The Role of the Renal Dopaminergic and the Prostaglandin Systems in Renal Uric Acid Metabolism in Patients with Essential Hypertension

1991 ◽  
Vol 67 (11) ◽  
pp. 1271-1281
Author(s):  
Naotoshi SATOH ◽  
Kenjiro KIKUCHI ◽  
Tohru HASEGAWA ◽  
Hiroaki KOMURA ◽  
Shin-ichiro SUZUKI ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Acid Metabolism
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