Evaluation of anti- rheumatic properties of thymol using carbon dots as nanocarrier on FCA induced arthritic rats

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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Solar Radiation and Vitamin D: Mitigating Environmental Factors in Autoimmune Disease

Journal of Environmental and Public Health ◽

10.1155/2012/619381 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 18

Author(s):

Gerry K. Schwalfenberg

Keyword(s):

Rheumatoid Arthritis ◽

Multiple Sclerosis ◽

Inflammatory Bowel Disease ◽

Vitamin D ◽

Type 1 Diabetes ◽

Autoimmune Disease ◽

Solar Radiation ◽

Inflammatory Bowel

This paper looks at the environmental role of vitamin D and solar radiation as risk reduction factors in autoimmune disease. Five diseases are considered: multiple sclerosis, type 1 diabetes, rheumatoid arthritis, autoimmune disease of the thyroid, and inflammatory bowel disease. Clinical relevant studies and factors that may indicate evidence that autoimmune disease is a vitamin D-sensitive disease are presented. Studies that have resulted in prevention or amelioration of some autoimmune disease are discussed. An example of the utility of supplementing vitamin D in an unusual autoimmune disease, idiopathic thrombocytic purpura, is presented.

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FRI0550 CAN CYTOKINE GENE POLYMORPHISMS BE USEFUL FOR THE THERAPEUTIC CHOICE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2067 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 876.2-877

Author(s):

S. Tsujimoto ◽

M. Shigesaka ◽

A. Tanaka ◽

Y. Ozaki ◽

T. Ito ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Gene Polymorphisms ◽

Therapeutic Response ◽

Bone Erosion ◽

Japanese Patients ◽

Cartilage Degradation ◽

Cytokine Gene ◽

Biological Dmards ◽

Cytokine Gene Polymorphisms

Background:Rheumatoid arthritis (RA) is a common autoimmune disease. It is characterized by systemic synovitis with bone erosion and joint cartilage degradation(1). Production of autoantibody is important for autoimmune disease. Cytokines play crucial roles in its pathogenesis(2). SNP distribution varies between races. Few studies have examined SNP targeted at Japanese patients. The analysis of cytokine gene polymorphisms is important factor of pathophysiology and treatment.Objectives:This analysis was aimed to investigate the association between cytokine gene polymorphisms and autoantibody and therapeutic response in Japanese RA patients.Methods:This study subjects consisted of 100 RA patients and 50 healthy controls. We extracted data on patient sex, age, disease duration, rheumatoid factor (RF), anti cyclic citrullinated peptide (anti-CCP) antibody and therapeutic response including methotrexate (MTX) and biological DMARDs. Genomic DNA was isolated from peripheral blood, these were genotyped for TNFα, TGFβ1, IL-6, IL-10 and IFNγ polymorphisms. We analyzed these data using a chi-square test.Results:IL-10 (-819 C/T and -592 C/A) revealed that there were significant decrease in the frequency of IL-10 (-819) CC genotype and (-592) CC genotype as compared to controls in RA patients. Genotyping of IL-10 showed that there was significant decrease ACC/ACC genotype (Table 1).IFNγ (+874 A/T) revealed that there was significant decrease in the frequency of TT genotype as compared to controls (Table 1).No significant differences in TNFα, TGFβ1and IL-6 genotypes and alleles frequency were observed between RA patients and control.TGFβ1(+869 A/T) in patients with anti-CCP antibody positive revealed that there was significant decrease in the frequency of TT genotype as compared to patients with anti-CCP antibody negative (Table 2).No significant association between RF and any cytokine gene polymorphism.Analyzing cytokine gene polymorphisms could be useful for treatment with MTX and biological DMARDs.Table 1.Table 2.Conclusion:IL-10 (-819 C/T, -592 C/A) and IFNγ (+874 A/T) polymorphism might be related to RA in Japanese population. In addition, TGFβ1(+869 A/T) polymorphism might be associated with the production of anti-CCP antibody. These results suggest that the analyzing cytokine gene polymorphisms may offer promise as useful factors in the choice of treatment for Japanese RA patients.References:[1] Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010; 376: 1094–108.[2] McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007 Jun;7(6):429-42.Disclosure of Interests:None declared

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AB0925-PARE A NARRATIVE REVIEW ASSESSING THE ROLE OF DIETARY SALT AS AN ENVIRONMENTAL RISK FACTOR FOR THE ONSET AND SEVERITY OF RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.2972 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1484.1-1484

Author(s):

S. Ahmed ◽

E. Nikiphorou ◽

J. Bayliss

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factor ◽

Autoimmune Disease ◽

Environmental Risk ◽

Narrative Review ◽

Environmental Risk Factor ◽

T Helper ◽

Dietary Salt ◽

Salt Consumption

Background:The role of dietary salt consumption in the etiopathogenesis of Rheumatoid Arthritis (RA), and autoimmune disease in general, has received renewed interest. This has been fueled by the increased prevalence of autoimmune disease worldwide correlating with western diets and heightened consumption of salt rich foods and also studies at the cellular level demonstrating induction of IL 17 producing T helper cells (Th17) by dietary salt.Objectives:To conduct a narrative review of observational studies and clinical trials on the role of dietary salt as an environmental risk factor for the onset and development of RA.Methods:A comprehensive search was done of the literature from 2010 to 2021, using the search terms dietary salt and RA; the native interfaces EBSCO and Ovid were used. Databases searched included Pubmed, Embase, EMCare, Medline and CINAHL using a Population, Exposure and Outcome framework; the MESH terms RA, risk factors, nutrition and salt were used. Data was extracted by an independent reviewer.Results:Out of the 72 studies initially identified, 50 were included in this review. Studies in murine models have demonstrated that high concentrations of sodium chloride promote the differentiation of T helper lymphocytes, via the serum- and glucocorticoid- inducible kinase 1 (SGK1) mediator towards the proinflammatory Th17 driven immune response. Six studies were carried out in human subjects. Study design ranged from cross sectional observational to nested case control studies. Sodium intake amongst participants characterized as having high intake, or being placed in the higher quartiles, ranged from 4.5-5grams per day. 5 out of 6 studies demonstrated that increased dietary salt consumption is associated with earlier onset RA. One study suggested an association between high salt intake and erosive disease at diagnosis and the development of anti-citrullinated protein antibodies (ACPA), although evidence was weak and from a single study only. Another study found that increased consumption of salt was only associated with risk of RA in smokers, highlighting the need to explore confounding variables further.Conclusion:This narrative review of the literature provides some evidence that supports a role of excess dietary salt consumption as a risk factor for the onset and severity of RA.Disclosure of Interests:None declared

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Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

PLoS ONE ◽

10.1371/journal.pone.0125192 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125192 ◽

Cited By ~ 62

Author(s):

Marta Krystyna Kosinska ◽

Taryn E. Ludwig ◽

Gerhard Liebisch ◽

Ruiyan Zhang ◽

Hans-Christian Siebert ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Molecular Species ◽

Articular Joint

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Minicircles for Investigating and Treating Arthritic Diseases

Pharmaceutics ◽

10.3390/pharmaceutics13050736 ◽

2021 ◽

Vol 13 (5) ◽

pp. 736

Author(s):

Yeri Alice Rim ◽

Yoojun Nam ◽

Narae Park ◽

Ji Hyeon Ju

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Gene Transfer ◽

Gene Delivery ◽

Viral Vectors ◽

Cartilage Tissue ◽

Minimal Size ◽

Gene Delivery System ◽

Related Disease ◽

Efficient Delivery

Gene delivery systems have become an essential component of research and the development of therapeutics for various diseases. Minicircles are non-viral vectors with promising characteristics for application in a variety of fields. With their minimal size, minicircles exhibit relatively high safety and efficient delivery of genes of interest into cells. Cartilage tissue lacks the natural ability to heal, making it difficult to treat osteoarthritis (OA) and rheumatoid arthritis (RA), which are the two main types of joint-related disease. Although both OA and RA affect the joint, RA is an autoimmune disease, while OA is a degenerative joint condition. Gene transfer using minicircles has also been used in many studies regarding cartilage and its diseased conditions. In this review, we summarize the cartilage-, OA-, and RA-based studies that have used minicircles as the gene delivery system.

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Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

10.1101/2021.02.03.429590 ◽

2021 ◽

Author(s):

Mihnea R. Mangalea ◽

David Paez-Espino ◽

Kristopher Kieft ◽

Anushila Chatterjee ◽

Jennifer A. Seifert ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

At Risk ◽

Autoimmune Disease ◽

Intestinal Microbiota ◽

Disease Development ◽

Metabolic Potential ◽

Metabolic Genes ◽

Auxiliary Metabolic Genes ◽

Citrullinated Protein ◽

Insight Into

SUMMARYRheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first degree relatives have been diagnosed with RA. We show that at-risk individuals harbor intestinal phage compositions that diverge based on CCP serology, are dominated by Lachnospiraceae phages, and originate from disparate ecosystems. These phages encode unique repertoires of auxiliary metabolic genes (AMGs) which associate with anti-CCP status, suggesting that these phages directly influence the metabolic and immunomodulatory capability of the microbiota. This work sets the stage for the use of phages as preclinical biomarkers and provides insight into a possible microbial-based causation of RA disease development.

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Gambaran Pasien Reumatoid Artritis di RSUD Arifin Achmad Riau Province 2015 - 2019

International Journal of Seocology ◽

10.26891/jik.v14i1.2020.45-51 ◽

2021 ◽

Vol 14 (1) ◽

pp. 45

Author(s):

Jelita Sri Agustin ◽

Huriatul Masdar ◽

Asrizal Asrizal

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Joint Pain ◽

Pharmacological Therapy ◽

Age Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Laboratory Examinations ◽

Chronic Autoimmune Disease

Rheumatoid Arthritis (RA) is a chronic autoimmune disease that causes tissue damage, deformity, and death if not treated immediately. The aim of this study to description of RA patients in the Regional General Hospital (RSUD) Arifin Achmad Riau Province 2015 – 2019. The results showed that total cases was 55 cases with the more common in female (87,3%) with most age group was 46-55 years (34,5%) and the main complaints were joint pain (85,5%). Rheumatoid arthritis patients with laboratory examinations were non-reactive rheumatoid factor (RF) levels by 20 patients out of 30 patients, levels of Anti-Citrullinated Protei Antibodies (ACPA) or Immunoglobulin G anti-Cyclic Citrulinated Protein (IgG anti-CCP) reactive by 3 patients out of 4 patients, levels C-Reactive Protein (CRP) abnormal by 18 patients out of 21 patients and levels Erythrocyte Sedimentation Rate (ESR) abnormal by 20 patients out of 23 patients. The results also showed that the most pharmacological therapy given was corticosteroid (87,3%)

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Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice

Food & Function ◽

10.1039/d1fo00709b ◽

2021 ◽

Author(s):

Chenyang Lu ◽

Ju Chen ◽

Congmin Yi ◽

Jiaojiao Han ◽

Qiuyue Shi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Autoimmune Disease ◽

Gut Microbiota ◽

Protective Effects ◽

Collagen Induced Arthritis ◽

Tuna Oil ◽

Beneficial Effects ◽

Chronic Autoimmune Disease

Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the components of tuna oil (TO) were firstly measured, and the beneficial effects of TO on collagen-induced...

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