Trans, trans-2,4-decadienal Induces Endothelial Cells Injury by Impairing Mitochondrial Function and Suppressing Autophagy

2021 ◽  
Author(s):  
Yuanyuan Hu ◽  
Guanhua Zhao ◽  
Lei Qin ◽  
Zhenlong Yu ◽  
Min Zhang ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Endothelial Cells ◽  
Mitochondrial Function ◽  
Crucial Role ◽  
Cardiovascular Health ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

Trans, trans-2,4-decadienal (tt-DDE), one of the major lipid peroxidation-derived aldehydes, has unique reactivity that is potentially toxic to human. Vascular endothelial cells play a crucial role in maintaining cardiovascular health....

scholarly journals Altered Functions of Human Blood-Derived Vascular Endothelial Cells by Simulated Microgravity

2020 ◽  
Vol 4 (1) ◽  
pp. 2-16
Author(s):  
Vidhya Ramaswamy ◽  
Allison Goins ◽  
Josephine B. Allen
Keyword(s):  
Endothelial Cells ◽  
Human Blood ◽  
Simulated Microgravity ◽  
Cardiovascular Health ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Altered Gravity ◽  
Adaptation Mechanism ◽  
Insight Into

AbstractRecently, the increase in incidence of cardiovascular degeneration associated with weightlessness has drawn much attention to the detrimental effects of space travel on cardiovascular health. Particularly, the regulatory role of the endothelium in cardiovascular degeneration has been studied extensively. The goal of this study was to understand the effects of simulated microgravity on the proliferative, secretory, and anti-thrombogenic functions of endothelial cells differentiated from human blood-derived progenitor cells. Exposure to simulated microgravity enhanced proliferation, as well as the release of soluble nitric oxide while downregulating the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6). Interestingly, the cells also upregulated gene expression of heat shock protein 70 (hsp70), which may be a potential adaptation mechanism of the cells to altered gravity conditions. However, the secretory and proliferative functions had no effect on the anti-thrombogenic functions of these cells. Their anti-coagulative and anti-thrombogenic abilities, as assessed by both upregulation of tissue plasminogen activator (tPA) and their ability to delay plasma clotting, were impaired on exposure to simulated microgravity. These results collectively provide a useful insight into various mechanisms involved in regulating anti-thrombogenic ability of the endothelium, as well as cardiovascular health in altered gravity conditions.

scholarly journals Aquaporin-1 Plays a Crucial Role in Estrogen-Induced Tubulogenesis of Vascular Endothelial Cells

2013 ◽  
Vol 98 (4) ◽  
pp. E672-E682 ◽  
Author(s):  
Li-Bo Zou ◽  
Shuai Shi ◽  
Run-Ju Zhang ◽  
Ting-Ting Wang ◽  
Ya-Jing Tan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Crucial Role ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Aquaporin 1

Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells

2005 ◽  
Vol 43 (3) ◽  
pp. 148-156 ◽  
Author(s):  
Sergio F. Martin ◽  
Subroto Chatterjee ◽  
Narasimham Parinandi ◽  
B. Rita Alevriadou
Keyword(s):  
Lipid Peroxidation ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Hypoxia Reoxygenation
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