Inhibition of Ras/ERK1/2 pathway contributes to the protective effect of Ginsenoside Re against intimal hyperplasia

2021 ◽  
Author(s):  
Chenying Gao ◽  
Kaina Zhang ◽  
Fanfan Liang ◽  
Wenzhuo Ma ◽  
Xixi Jiang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Endovascular Treatment ◽  
Carotid Stenosis ◽  
Vascular Injury ◽  
Intimal Hyperplasia ◽  
Neointimal Hyperplasia ◽  
Ginsenoside Re ◽  
Term Efficacy

Neointimal hyperplasia is the major cause of carotid stenosis after vascular injury, which restricts the long-term efficacy of endovascular treatment and endarterectomy in preventing stenosis. Ginsenoside Re (Re) is a...

Long-term efficacy of endovascular treatment of isolated iliac artery aneurysms

2012 ◽  
Vol 118 (1) ◽  
pp. 62-73 ◽  
Author(s):  
R. Fossaceca ◽  
G. Guzzardi ◽  
M. Di Terlizzi ◽  
I. Divenuto ◽  
P. Cerini ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Iliac Artery ◽  
Term Efficacy ◽  
Isolated Iliac Artery Aneurysms

Endovascular treatment of carotid-cavernous fistulae: Long-term efficacy and prognostic factors

2016 ◽  
Vol 39 (1) ◽  
pp. 74-81 ◽  
Author(s):  
S. Stéphan ◽  
R. Blanc ◽  
M. Zmuda ◽  
C. Vignal ◽  
M. Barral ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Endovascular Treatment ◽  
Term Efficacy

The National Institute of Child Health and Human Development and Phenylketonuria

PEDIATRICS ◽  
2003 ◽  
Vol 112 (Supplement_4) ◽  
pp. 1514-1515 ◽  
Author(s):  
Duane Alexander
Keyword(s):  
Mental Retardation ◽  
Child Health ◽  
Protective Effect ◽  
Human Development ◽  
Fetal Development ◽  
Newborn Infants ◽  
Adverse Impact ◽  
Term Efficacy

The National Institute of Child Health and Human Development (NICHD) was established shortly after the Guthrie test for screening newborn infants for phenylketonuria (PKU) was introduced. The NICHD supported the study demonstrating the long-term efficacy of screening and a low-phenylalanine diet in preventing mental retardation. With the identification of the adverse impact on fetal development of high intrauterine phenylalanine exposure from a mother with PKU, the NICHD organized and supported the study reported here, demonstrating the protective effect of phenylalanine restriction of the mother’s diet during pregnancy. The study provides clear guidance for the management of pregnancy in women with PKU.

scholarly journals New Devices Designed to Improve the Long-Term Results of Endovascular Treatment of Intracranial Aneurysms

2004 ◽  
Vol 10 (2) ◽  
pp. 93-102 ◽  
Author(s):  
J. Raymond ◽  
P. Leblanc ◽  
M. Chagnon ◽  
G. Gévry ◽  
J.-P. Collet ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Intracranial Aneurysms ◽  
Controlled Trial ◽  
Long Term Results ◽  
Secondary Outcome ◽  
Endovascular Coiling ◽  
Double Blind Study ◽  
Double Blind ◽  
Term Efficacy

Endovascular coiling can improve the outcome of patients with ruptured intracranial aneurysms, but angiographic recurrences are frequent compared to surgical clipping. New coils or devices have been introduced to improve long-term results of endovascular treatment but none have been the object of a valid clinical trial. We have proposed a multicentric randomized double-blind study comparing radioactive and standard coil occlusion of aneurysms. The purpose of this article is to review issues that are specific to the design of clinical trials to assess embolic agents that could improve the long-term efficacy of endovascular treatment of intracranial aneurysms. The proposed trial is a randomized, multi-center, prospective, controlled trial comparing the new generation coils to standard platinum coils. Blinding, if at all possible, is preferable to minimize bias, at least for follow-up angiographic studies that should cover a period of 18 months. All patients with an intracranial aneurysm eligible for endovascular treatment would be proposed to participate. The study would enrol approximately 500 patients equally divided between the two groups, recruited within two years, to demonstrate a decrease in the recurrence rate, the primary outcome measure, from 20% to 10%. Secondary outcome measures should assure that complications, initial clinical and angiographic results remain unchanged. Independent data safety and monitoring committees are crucial to the credibility of trials and to ensure scientific rigor and objectivity. The scientific demonstration of an improved long-term efficacy, without significant compromise regarding safety, is mandatory before considering the widespread use of a new embolic device for the endovascular treatment of aneurysms.

Neurointerventional Training for Neurosurgeons: Past, Present, and Future

2019 ◽  
Vol 16 (02/03) ◽  
pp. 094-098
Author(s):  
Girish Rajpal
Keyword(s):  
Endovascular Treatment ◽  
Vascular Lesions ◽  
Term Efficacy ◽  
Novel Treatment ◽  
International Subarachnoid Aneurysm Trial ◽  
Detachable Coils ◽  
Recent Addition ◽  
Mass Lesions ◽  
Aneurysm Coiling

AbstractEndovascular therapy as any other specialty has continuously been developed since 1904, but acceptability among neurosurgeons remains low despite being other subspecialties and techniques, like endoscope and for that matter microscope also, being adopted very rapidly. From injecting particles for vascular lesions to balloons for fistulas and arteriovenous malformations and embolizing agents to detachable coils for aneurysm coiling, it has come a long way. Old generations of neurosurgeons used to perform carotid puncture for diagnosing mass lesions, but once CT/MRI came in to the picture, this procedure was stopped and handed over to radiologists. A debate continues among neurosurgeons about the feasibility of aneurysm coiling since international subarachnoid aneurysm trial (ISAT) and doubts about the long-term efficacy of this novel treatment cost a subspecialty. With the recent addition of endovascular treatment of stroke and long-term efficacy of endovascular treatment of aneurysm, there is a lot of debate among clinicians and nonclinicians about who will be the true heir of this sub specialty.

Long-term Results of Tapered Stents in Endovascular Treatment of Carotid Stenosis

2017 ◽  
Vol 45 ◽  
pp. 79-84 ◽  
Author(s):  
Gioele Simonte ◽  
Beatrice Fiorucci ◽  
Giacomo Isernia ◽  
Gianbattista Parlani ◽  
Fabio Verzini ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Carotid Stenosis ◽  
Long Term Results

scholarly journals LONG-TERM EFFICACY OF ENDOVASCULAR TREATMENT FOR PATIENTS WITH CRITICAL LIMB ISCHEMIA DUE TO ISOLATED BELOW THE KNEE LESIONS

2012 ◽  
Vol 59 (13) ◽  
pp. E2048 ◽  
Author(s):  
Kiyonori Nanto ◽  
Osamu iida ◽  
Yoshimitsu Soga ◽  
Kenji Suzuki ◽  
Terutoshi Yamaoka ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Term Efficacy ◽  
Below The Knee

scholarly journals A Randomized Trial Comparing Platinum and Hydrogel-Coated Coils in Patients Prone to Recurrence after Endovascular Treatment (The PRET Trial)

2008 ◽  
Vol 14 (1) ◽  
pp. 73-83 ◽  
Author(s):  
J. Raymond ◽  
D. Roy ◽  
P.M. White ◽  
D. Fiorella ◽  
R. Chapot ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Randomized Trial ◽  
Coil Embolization ◽  
Scientific Evidence ◽  
Term Efficacy ◽  
Better Than

New coils have been designed to preserve the safety of coil embolization while improving on long-term efficacy. There is currently no scientific evidence that one type of coil material is better than another. The recurrence problem may be more pressing in certain types of patients, such as patients with large aneurysms or those already presenting with angiographic recurrences.

CO2 Laser Offers Long-Term Efficacy

2008 ◽  
Vol 39 (9) ◽  
pp. 31
Author(s):  
ROBIN TURNER
Keyword(s):  
Co2 Laser ◽  
Term Efficacy
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