Successes and Challenges in Multiscale Modelling of Artificial Metalloenzymes: the Case Study of POP-Rh2 Cyclopropanase

2021 ◽  
Author(s):  
José-Emilio Sánchez-Aparicio ◽  
Giuseppe Sciortino ◽  
Eric Mates-Torres ◽  
A. Lledos ◽  
Jean-Didier Maréchal
Keyword(s):  
Molecular Modelling ◽  
Multiscale Modelling ◽  
Artificial Metalloenzymes ◽  
Metalloenzyme Design ◽  
Successes And Challenges

Molecular modelling applications in metalloenzyme design are still scarce due to a series of challenges. In top of that, the simulations of metal-mediated binding and the identification of catalytic competent...

scholarly journals Development and application of a hybrid implementation research framework to understand success in reducing under-5 mortality in Rwanda

2021 ◽  
Vol 5 ◽  
pp. 72
Author(s):  
Lisa R. Hirschhorn ◽  
Miriam Frisch ◽  
Jovial Thomas Ntawukuriryayo ◽  
Amelia VanderZanden ◽  
Kateri Donahoe ◽  
...  
Keyword(s):  
Health System ◽  
Implementation Research ◽  
Contextual Factors ◽  
Common Pathway ◽  
Middle Income ◽  
Middle Income Countries ◽  
Mixed Methods Case Study ◽  
Hybrid Framework ◽  
Successes And Challenges

Background: We describe the development and testing of a hybrid implementation research (IR) framework to understand the pathways, successes, and challenges in addressing amenable under-5 mortality (U5M) – deaths preventable through health system-delivered evidence-based interventions (EBIs) – in low- and middle-income countries (LMICs). Methods: We reviewed existing IR frameworks to develop a hybrid framework designed to better understand U5M reduction in LMICs from identification of leading causes of amenable U5M, to EBI choice, identification and testing of strategies, work to achieve sustainability at scale and key contextual factors. We then conducted a mixed-methods case study of Rwanda using the framework to explore its utility in understanding the steps the country took in EBI-related decision-making and implementation between 2000-2015, key contextual factors which hindered or facilitated success, and extract actionable knowledge for other countries working to reduce U5M. Results: While relevant frameworks were identified, none individually covered the scope needed to understand Rwanda’s actions and success. Building on these frameworks, we combined and adapted relevant frameworks to capture exploration, planning, implementation, contextual factors in LMICs such as Rwanda, and outcomes beyond effectiveness and coverage. Utilizing our hybrid framework in Rwanda, we studied multiple EBIs and identified a common pathway and cross-cutting strategies and contextual factors that supported the country’s success in reducing U5M through the health system EBIs. Using these findings, we identified transferable lessons for other countries working to accelerate reduction in U5M. Conclusions: We found that a hybrid framework building on and adapting existing frameworks was successful in guiding data collection and interpretation of results, emerging new insights into how and why Rwanda achieved equitable introduction and implementation of health system EBIs that contributed to the decline in U5M, and generated lessons for countries working to drop U5M.

scholarly journals Examining Distance Learners in Hybrid Synchronous Instruction: Successes and Challenges

2017 ◽  
Vol 21 (4) ◽  
Author(s):  
Enilda Romero-Hall ◽  
Cristiane Rocha Vicentini
Keyword(s):  
Data Analysis ◽  
Focus Group ◽  
The Other ◽  
Distance Learners ◽  
Electronic Journals ◽  
Face To Face ◽  
Individual Interviews ◽  
Study Results ◽  
Successes And Challenges

This paper reports on a case study investigating distance learners participating in graduate-level hybrid synchronous instruction. This research helps inform the design of hybrid synchronous instruction in which face-to-face and distance learners engage in class sessions. Data were collected using electronic journals, individual interviews, and a focus group. The results of the data analysis provide evidence that in this case, hybrid synchronous instruction improved the study habits of distance learners. On the other hand, the case study results also revealed that there are challenging pedogogical aspects which the distance learners had to overcome during hybrid synchronous instruction. Among such challenges were the interactions, relationships, and communication exchanges between distance learners, their face-to-face counterparts, and the instructor.

Water in the Time of Drought II: Lessons from Droughts around the World

2021 ◽  
Author(s):  
Raphaëlle Ortiz ◽  
Anamaría Núñez ◽  
Corinne Cathala ◽  
Ana R. Rios ◽  
Mauro Nalesso
Keyword(s):  
Best Practices ◽  
Technical Note ◽  
Lessons Learned ◽  
Institutional Frameworks ◽  
The World ◽  
Relevant Case ◽  
Management Policies ◽  
Successes And Challenges

This technical note is an update to the previous "Water in the Time of Drought: Lessons from Five Droughts Around the World", published in 2018. It explores drought situations and policies in Spain (including the Canary Islands), Chile, Mexico, the dry corridor between Honduras, Guatemala, and El Salvador, Brazil, and South Africa. Each of these countries has recently dealt with droughts and/or developed long-term solutions to manage them. HydroBID, a tool developed by the IDB, will be presented through relevant case studies. After defining drought experiences and institutional frameworks in each country, the brief will explore the successes and challenges of national drought and water management policies. Best practices and lessons learned will be extracted from each case study to help policymakers better prepare for droughts.

Creating a Quality Online Early Childhood Program Focused on Building Community and Program Improvement

2019 ◽  
pp. 93-118
Author(s):  
Jade Burris ◽  
Catherine Prudhoe
Keyword(s):  
Early Childhood ◽  
Program Improvement ◽  
Graduate Degree ◽  
Design Development ◽  
Online Programs ◽  
Face To Face ◽  
Early Childhood Professionals ◽  
Building Community ◽  
Successes And Challenges

This chapter explores the intentional design, development, and continued improvement of an online graduate degree program for early childhood education (ECE) teachers and administrators. The authors will discuss the initial face-to-face design and the transition to an online program to better meet the needs of its students. The authors will also discuss the successes and challenges met throughout this process while providing an overview of the field of ECE. In the process, they will consider the unique demands of working in childcare and explain why using technology to offer online programs was an appropriate solution to the challenges experienced by early childhood professionals (ECPs). They will address why online delivery is a preferred method of professional development (PD) among ECPs. Further, this chapter will include an analysis of survey data on program quality and course satisfaction, providing practical recommendations based on what was learned from this case study.

Vulnerability of the Lakshadweep Coral Islands in India and Strategies for Mitigating Climate Change Impacts

2017 ◽  
pp. 64-96
Author(s):  
B. K. Khanna
Keyword(s):  
Climate Change ◽  
Action Plan ◽  
Climate Change Impacts ◽  
Change Strategies ◽  
Development Goals ◽  
Change Impact ◽  
Successes And Challenges ◽  
Lakshadweep Archipelago ◽  
Coral Islands

Strategies for mitigating climate change impact on the vulnerable Lakshadweep coral islands have been drawn up in accordance with the principles, guidelines and strategies laid down in the Indian National Action Plan on Climate Change (NAPCC). The region most vulnerable to inundation from accelerated sea level rise (at least 40 cm by 2100) is the Lakshadweep archipelago. The first section of the chapter reviews the origin and geophysical features, climate profile, sectoral impact of climate change and vulnerabilities of Lakshdweep. The second section deals with climate change strategies and their adaptation, recommending appropriate actions for coping strategies to be adopted by local communities to be resilient against the adverse impacts of climate change. The third section outlines the Lakshadweep Action Plan for Climate Change (LAPCC) and the fourth section describes integrating LAPCC within the NAPCC, successes and challenges ahead. For small islands it is a notable case study to emulate, mitigating the effects of climate change while not deviating from development goals.

scholarly journals Five Year Pediatric Use of a Digital Wearable Fitness Device: Lessons from a Pilot Case Study

2020 ◽  
Author(s):  
Kimayani D. Butte ◽  
Amir Bahmani ◽  
Atul J. Butte ◽  
Xiao Li ◽  
Michael P. Snyder
Keyword(s):  
Pediatric Case ◽  
School Work ◽  
Healthy Behaviors ◽  
Step Counts ◽  
Pediatric Study ◽  
Pediatric Use ◽  
Device Use ◽  
New Applications ◽  
Successes And Challenges

AbstractObjectivesWearable fitness devices are increasingly used by the general population, with new applications being proposed and designed for healthy adults as well as adults with chronic diseases. Fewer, if any, studies of these devices have been conducted in healthy adolescents and teenagers, especially over a long period of time. The goal of this work was to document the successes and challenges involved in 5 years of a wearable fitness device use in a pediatric case study.Materials and MethodsComparison of five years of step counts and minutes asleep from a teenaged girl and her father.ResultsAt 60 months, this may be the longest reported pediatric study involving a wearable fitness device, and the first simultaneously involving a parent and a child. We find step counts to be significantly higher for both the adult and teen on school/work days, along with less sleep. The teen walked significantly less towards the end of the 5 year study. Surprisingly, many of the adult’s and teen’s sleeping and step counts were correlated, possibly due to coordinated behaviors.DiscussionWe end with several recommendations for pediatricians and device manufacturers, including the need for constant adjustments of stride length and calorie counts as teens are growing.ConclusionWith periodic adjustments for growth, this pilot study shows these devices can be used for more accurate and consistent measurements in adolescents and teenagers over longer periods of time, to potentially promote healthy behaviors.

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