Biocatalytic oligomerization of azoles; experimental and computational studies

2021 ◽  
Author(s):  
Neda Mashhadi ◽  
Keith E. Taylor ◽  
Nihar Biswas ◽  
Paul Meister ◽  
James W. Gauld
Keyword(s):  
Wastewater Treatment ◽  
Computational Studies ◽  
Soybean Peroxidase ◽  
Radical Coupling

Soybean peroxidase effectively transformed selected amino- and hydroxyl-azoles by radical coupling to dimers and trimers, showing feasibility for wastewater treatment.

scholarly journals SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dong Zou ◽  
Lishe Gan ◽  
Fan Yang ◽  
Huan Wang ◽  
Youge Pu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Experimental Evidence ◽  
Radical Anion ◽  
Reaction Pathway ◽  
Cycloaddition Reaction ◽  
Electron Donors ◽  
Ring Closure ◽  
Computational Studies ◽  
Metal Free ◽  
Radical Coupling

AbstractThe use of nitroarenes as amino sources in synthesis is challenging. Herein is reported an unusual, straightforward, and transition metal-free method for the net [3 + 2]-cycloaddition reaction of 2-azaallyl anions with nitroarenes. The products of this reaction are diverse 2,5-dihydro-1,2,4-oxadiazoles (>40 examples, up to 95% yield). This method does not require an external reductant to reduce nitroarenes, nor does it employ nitrosoarenes, which are often used in N–O cycloadditions. Instead, it is proposed that the 2-azaallyl anions, which behave as super electron donors (SEDs), deliver an electron to the nitroarene to generate a nitroarene radical anion. A downstream 2-azaallyl radical coupling with a newly formed nitrosoarene is followed by ring closure to afford the observed products. This proposed reaction pathway is supported by computational studies and experimental evidence. Overall, this method uses readily available materials, is green, and exhibits a broad scope.

Soybean peroxidase for industrial wastewater treatment: a mini review

2014 ◽  
Vol 9 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Aaron Steevensz ◽  
Laura G. Cordova Villegas ◽  
Wei Feng ◽  
Keith E. Taylor ◽  
Jatinder K. Bewtra ◽  
...  
Keyword(s):  
Wastewater Treatment ◽  
Industrial Wastewater ◽  
Soybean Peroxidase ◽  
Industrial Wastewater Treatment

scholarly journals Unravelling the mechanism of cobalt-catalysed remote C–H nitration of 8-aminoquinolinamides and expansion of substrate scope towards 1-naphthylpicolinamide

2020 ◽  
Vol 11 (2) ◽  
pp. 534-542
Author(s):  
Melody Chu ◽  
Oriol Planas ◽  
Anna Company ◽  
Xavi Ribas ◽  
Alex Hamilton ◽  
...  
Keyword(s):  
High Spin ◽  
Computational Studies ◽  
Radical Coupling

Computational studies of the Co-catalyzed remote nitration of 8-aminoquinolinamides have found the mechanism to operate through an unexpected high-spin induced remote radical-coupling.

Sign in / Sign up

Export Citation Format

Share Document