Six-week inhalation of lead oxide nanoparticles in mice affects antioxidant defense, immune response, kidneys, intestine and bones

2022 ◽  
Author(s):  
Jana Tulinska ◽  
Zora Krivošíková ◽  
Aurelia Liskova ◽  
Miroslava Lehotska Mikusova ◽  
Vlasta Masanova ◽  
...  
Keyword(s):  
Immune Response ◽  
Hazard Assessment ◽  
Lead Oxide ◽  
Antioxidant Defense ◽  
Inhalation Exposure ◽  
Industrial Processes ◽  
Oxide Nanoparticles ◽  
Limited Information

Due to widespread use in various industrial processes, the risk of inhalation exposure to lead oxide nanoparticles (PbO NPs) is growing and limited information evokes the need for hazard assessment...

The Experimental Study of Cardiotoxic Effects of Lead Oxide Nanoparticles by Their Various Routes of Exposure

2020 ◽  
pp. 67-72
Author(s):  
Minigalieva IA ◽  
MP Sutunkova ◽  
SV Klinova ◽  
SN Solovyova ◽  
LI Privalova ◽  
...  
Keyword(s):  
Lead Oxide ◽  
Inhalation Exposure ◽  
Female Rats ◽  
Male Rats ◽  
Oxide Nanoparticles ◽  
Exposure System ◽  
Adverse Health Effects ◽  
Urine Concentrations ◽  
Biochemical Indices

Background: Lead oxide nanoparticles are emitted in the workplace air of copper smelters. They are also a by-product in many other metallurgical industries. Objectives: Adverse health effects of lead oxide nanoparticles (PbO-NPs) were assessed in vivo using various routes of exposure with special attention paid to particle cardiotoxicity. Materials and methods: The subacute inhalation experiments were conducted on outbred female rats exposed to the generated aerosol of PbO-NPs in the concentration of 1.30 ± 0.10 mg/m3, 4 hours a day during five consecutive days, using the Nose-Only Inhalation Exposure System. The study of subchronic exposure to PbO-NPs was conducted on male rats using intraperitoneal injections made thrice a week during six weeks (18 injections in total). Conclusions: Following both types of exposure to PbO-NPs, we observed changes in toxicological indices including those specific for lead including a decrease in hemoglobin counts, an increase in blood reticulocyte counts and urine concentrations of δ-aminolevulenic acid. The subacute inhalation exposure to PbO-NPs affected electrocardiographic findings in animals (an increase in amplitudes of P and T waves) while the subchronic intraperitoneal injections decreased blood pressure and changed biochemical indices of the cardiovascular system (decreased activity of the angiotensin-converting enzyme and the concentration of endodelin-1).

MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE

2021 ◽  
pp. 3-13
Author(s):  
M. Р. Sutunkova ◽  
S. N. Solovyeva ◽  
I. N. Chernyshov ◽  
S. V. Klinova ◽  
V. B. Gurvich ◽  
...  
Keyword(s):  
Lead Oxide ◽  
Aminolevulinic Acid ◽  
Inhalation Exposure ◽  
Average Concentration ◽  
The Body ◽  
Female Rats ◽  
White Female ◽  
Control Group ◽  
Oxide Nanoparticles ◽  
Sham Exposure

Outbred white female rats were exposed to an aerosol of lead oxide nanoparticles in a nose-only inhalation setup at an average concentration of 1.30 ± 0.10 mg / m3 during 5 days for 4 hours a day. In parallel, the control group of rats was subjected to sham exposure under similar conditions. The deposition of nanoparticles in the lungs and in the olfactory region of the brain was detected using transmission electron microscopy. Some disorders of the body state were detected in the exposed group, some of which can be considered as the result of a lead-specific toxic effect (an increase in the proportion of reticulocytes and in urinary excretion of δ-aminolevulinic acid), and others - the result of nanoparticles circumventing the blood-brain barrier (axon demyelination, vacuolization of the neurons’ cytoplasm).

scholarly journals Preparation and Characterization of Lead Oxide Nanoparticles by Laser Ablation as Antibacterial Agent

2017 ◽  
Vol 14 (4) ◽  
pp. 801-807
Author(s):  
Baghdad Science Journal
Keyword(s):  
Laser Ablation ◽  
Lead Oxide ◽  
Laser Energy ◽  
Laser Pulses ◽  
Diffusion Method ◽  
Lead Target ◽  
Oxide Nanoparticles ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

In this work, lead oxide nanoparticles were prepared by laser ablation of lead target immersed in deionized water by using pulsed Nd:YAG laser with laser energy 400 mJ/pulse and different laser pulses. The chemical bonding of lead oxide nps was investigated by Fourier Transform Infrared (FTIR); surface morphology and optical properties were investigated by Scanning Electron Microscope (SEM) and UV-Visible spectroscopy respectively, and the size effect of lead oxide nanoparticles was studied on its antibacterial action against two types of bacteria Gram-negitive (Escherichia coli) and Gram-positive (Staphylococcusaurus) by diffusion method. The antibacterial property results show that the antibacterial activity of the Lead oxide NPs was inversely proportional to the size of the nanoparticles in both Gram-negative and Gram-positive, and also it has been found that Gram-positive bacteria possess have greater sensitivity and less resistance to the lead oxide nanoparticles compared with Gram-negative bacteria.

In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors

Toxicology ◽  
2017 ◽  
Vol 380 ◽  
pp. 72-93 ◽  
Author(s):  
Ilzira A. Minigalieva ◽  
Boris A. Katsnelson ◽  
Vladimir G. Panov ◽  
Larisa I. Privalova ◽  
Anatoly N. Varaksin ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Copper Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Lead Oxide ◽  
Oxide Nanoparticles ◽  
In Vivo Toxicity

scholarly journals Synthesis of (Poly-methyl Methacrylate-lead Oxide) Nanocomposites and Studying their A.C Electrical Properties for Piezoelectric Applications

2018 ◽  
Vol 7 (4) ◽  
pp. 547-551
Author(s):  
Dalal Hassan ◽  
Ahmed Hashim
Keyword(s):  
Electrical Conductivity ◽  
Dielectric Constant ◽  
Dielectric Loss ◽  
Methyl Methacrylate ◽  
Electrical Resistance ◽  
Lead Oxide ◽  
Piezoelectric Materials ◽  
Oxide Nanoparticles ◽  
Poly Methyl Methacrylate ◽  
Increase With Increase

Piezoelectric materials have been prepared from (poly-methyl methacrylate-lead oxide) nanocomposites for electronic applications. The lead oxide nanoparticles were added to poly-methyl methacrylate by different concentrations are (4, 8, and 12) wt%. The structural and dielectric properties of nanocomposites were studied. The results showed that the dielectric constant and dielectric loss of nanocomposites decrease with increase in frequency of applied electric field. The A.C electrical conductivity increases with increase in frequency. The dielectric constant, dielectric loss and A.C electrical conductivity of poly-methyl methacrylate increase with increase in lead oxide nanoparticles concentrations. The results of pressure sensor showed that the electrical resistance of (PMMA-PbO2) nanocomposites decreases with increase in pressure.

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