Metal-organic framework-encapsulated nanoparticles for synergetic chemo/chemo-dynamic therapy with targeted H2O2 self-supplying

2021 ◽  
Author(s):  
Ruixue Cui ◽  
Jing Shi ◽  
Zhiliang Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Therapy ◽  
Therapeutic Strategy ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dynamic Therapy ◽  
Metal Organic ◽  
Encapsulated Nanoparticles

Nanocatalytic cancer therapy based on chemo-dynamic therapy, which converts hydrogen peroxide (H2O2) into toxic reactive oxygen species via Fenton-like reaction, is regarded as a promising therapeutic strategy due to its...

Bimetal Metal-Organic Framework Domino Micro-Reactor for Synergistic Antibacterial Starvation/Chemodynamic Therapy and Robust Wound Healing

Nanoscale ◽  
2022 ◽  
Author(s):  
Liming Peng ◽  
Xuyang Yang ◽  
Song Wang ◽  
Joseph Yau Kei Chan ◽  
Yong Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic ◽  
Micro Reactor ◽  
Organic Framework

Antibacterial chemodynamic therapy (aCDT) has captured considerable attention in the treatment of pathogen-induced infection due to its potential to inactivate bacteria through germicidal reactive oxygen species (ROS). However, the lifespan...

A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

2019 ◽  
Vol 55 (89) ◽  
pp. 13374-13377 ◽  
Author(s):  
Wee Kong Ong ◽  
Deblin Jana ◽  
Yanli Zhao
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Therapy ◽  
Reactive Oxygen ◽  
Species Level ◽  
Reactive Oxygen Species Level ◽  
Oxygen Species ◽  
Anticancer Treatment ◽  
Intracellular Glucose

A novel silica nanosystem is fabricated to convert intracellular glucose to hydrogen peroxide for enhancing reactive oxygen species level and triggering p-quinomethane release to scavenge glutathione, achieving synergistic anticancer treatment.

Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

2020 ◽  
Vol 8 (21) ◽  
pp. 4620-4626
Author(s):  
Shuiling Jin ◽  
Lanling Weng ◽  
Zhi Li ◽  
Zhenzhen Yang ◽  
Lili Zhu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Biomimetic Mineralization ◽  
Enzyme Cascade ◽  
Metal Organic ◽  
Cancer Tissues

Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.

An Imine‐Linked Metal–Organic Framework as a Reactive Oxygen Species Generator

2020 ◽  
Author(s):  
Xiaomin Li ◽  
Junyi Wang ◽  
Fengfeng Xue ◽  
Yichen Wu ◽  
Hualong Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal–Organic Framework Derived Multicomponent Nanoagent as a Reactive Oxygen Species Amplifier for Enhanced Photodynamic Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (10) ◽  
pp. 13500-13511 ◽  
Author(s):  
Dongdong Wang ◽  
Huihui Wu ◽  
Guangbao Yang ◽  
Cheng Qian ◽  
Long Gu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic ◽  
Organic Framework

Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation

2021 ◽  
Author(s):  
Qian Wu ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Organelle Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of...

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