scholarly journals Electrochemical control of [FeFe]-hydrogenase single crystals reveals complex redox populations at the catalytic site

2021 ◽  
Author(s):  
Simone Morra ◽  
Jifu Duan ◽  
Martin Winkler ◽  
Philip A Ash ◽  
Thomas Happe ◽  
...  
Keyword(s):  
Single Crystals ◽  
Active Site ◽  
Catalytic Site ◽  
Highly Efficient ◽  
Electrochemical Control

Elucidating the distribution of intermediates at the active site of redox metalloenzymes is vital to understanding their highly efficient catalysis. Here we demonstrate that it is possible to generate, and...

Dual-Function, Light Switchable Cobalt Catalysis via Active Site Metamorphosis

2019 ◽  
Author(s):  
Enrico Bergamaschi ◽  
Frédéric Beltran ◽  
Christopher Teskey
Keyword(s):  
Visible Light ◽  
Active Site ◽  
Catalytic Site ◽  
Dual Function ◽  
Catalytic Systems ◽  
Hydride Complex ◽  
Dual Functional ◽  
Multiple Processes ◽  
Olefin Migration

<p></p><p></p><p>Switchable catalysis offers opportunities to control the rate or selectivity of a reaction <i>via</i> a stimulus such as pH or light. However, few examples of switchable catalytic systems that can facilitate multiple processes exist. Here we report a rare example of such dual-functional, switchable catalysis. Featuring an easily prepared, bench-stable cobalt(I) hydride complex in conjunction with pinacolborane, we can completely alter the reaction outcome between two widely employed transformations – olefin migration and hydroboration – with visible light as the sole trigger. This dichotomy arises from ligand photodissociation which leads to metamorphosis of the active catalytic site, resulting in divergent mechanistic pathways.</p><p></p><p></p>

Rutile TiO2 single crystals delivering enhanced photocatalytic oxygen evolution performance

Nanoscale ◽  
2021 ◽  
Author(s):  
Bing Fu ◽  
Zhijiao Wu ◽  
Kai Guo ◽  
Lingyu Piao
Keyword(s):  
Catalytic Activity ◽  
Single Crystals ◽  
Oxygen Evolution ◽  
Water Oxidation ◽  
Charge Separation ◽  
High Surface ◽  
Rutile Tio2 ◽  
Highly Efficient ◽  
Photogenerated Charge Separation

Owing to their scientific and technological importance, the development of highly efficient photocatalytic water oxidation systems with rapid photogenerated charge separation and high surface catalytic activity has highly desirable for...

Highly efficient extraction of a proton beam by using bent single crystals

2000 ◽  
Vol 43 (1) ◽  
pp. 11-15 ◽  
Author(s):  
A. A. Arkhipenko ◽  
A. G. Afonin ◽  
V. M. Biryukov ◽  
V. A. Gavrilushkin ◽  
V. N. Gres’ ◽  
...  
Keyword(s):  
Single Crystals ◽  
Proton Beam ◽  
Highly Efficient ◽  
Efficient Extraction

Spectroscopic studies on plastocyanin single crystals: a detailed electronic structure determination of the blue copper active site

1981 ◽  
Vol 103 (15) ◽  
pp. 4382-4388 ◽  
Author(s):  
K. W. Penfield ◽  
R. R. Gay ◽  
R. S. Himmelwright ◽  
N. C. Eickman ◽  
V. A. Norris ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Single Crystals ◽  
Structure Determination ◽  
Active Site ◽  
Spectroscopic Studies ◽  
Blue Copper

Highly efficient up-conversion green emission in Ho/Yb co-doped yttria-stabilized zirconia single crystals

2019 ◽  
Vol 209 ◽  
pp. 95-101 ◽  
Author(s):  
Xiaojun Tan ◽  
Shoulei Xu ◽  
Fenhong Liu ◽  
Xiangyu Wang ◽  
Bernard A. Goodman ◽  
...  
Keyword(s):  
Single Crystals ◽  
Green Emission ◽  
Yttria Stabilized Zirconia ◽  
Stabilized Zirconia ◽  
Highly Efficient ◽  
Co Doped

Active site engineering by surface sulfurization for a highly efficient oxygen evolution reaction: a case study of Co3O4 electrocatalysts

2018 ◽  
Vol 6 (45) ◽  
pp. 22497-22502 ◽  
Author(s):  
Ying Pan ◽  
Hangjuan Ren ◽  
Haiwei Du ◽  
Fuyang Cao ◽  
Yifeng Jiang ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Oxygen Evolution ◽  
Active Site ◽  
Oxygen Evolution Reaction ◽  
Highly Efficient

Enhanced catalytic activity of Co3O4@CoSx through surface sulfurization.

Well‐Balanced Ambipolar Organic Single Crystals toward Highly Efficient Light‐Emitting Devices

2020 ◽  
Vol 30 (49) ◽  
pp. 2002422
Author(s):  
Ming‐Hui An ◽  
Ran Ding ◽  
Qin‐Cheng Zhu ◽  
Gao‐Da Ye ◽  
Hai Wang ◽  
...  
Keyword(s):  
Single Crystals ◽  
Light Emitting ◽  
Light Emitting Devices ◽  
Highly Efficient

scholarly journals Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases

2020 ◽  
Vol 295 (20) ◽  
pp. 6972-6982
Author(s):  
Dakshinamurthy Sivakumar ◽  
Vikash Kumar ◽  
Michael Naumann ◽  
Matthias Stein
Keyword(s):  
Active Site ◽  
Electrostatic Interactions ◽  
Active Form ◽  
Cysteine Proteases ◽  
Binding Pocket ◽  
Catalytic Triad ◽  
Catalytic Site ◽  
Dynamics Simulation ◽  
Active Site Residues ◽  
Catalytically Active

The ovarian tumor domain (OTU) deubiquitinylating cysteine proteases OTUB1 and OTUB2 (OTU ubiquitin aldehyde binding 1 and 2) are representative members of the OTU subfamily of deubiquitinylases. Deubiquitinylation critically regulates a multitude of important cellular processes, such as apoptosis, cell signaling, and growth. Moreover, elevated OTUB expression has been observed in various cancers, including glioma, endometrial cancer, ovarian cancer, and breast cancer. Here, using molecular dynamics simulation approaches, we found that both OTUB1 and OTUB2 display a catalytic triad characteristic of proteases but differ in their configuration and protonation states. The OTUB1 protein had a prearranged catalytic site, with strong electrostatic interactions between the active-site residues His265 and Asp267. In OTUB2, however, the arrangement of the catalytic triad was different. In the absence of ubiquitin, the neutral states of the catalytic-site residues in OTUB2 were more stable, resulting in larger distances between these residues. Only upon ubiquitin binding did the catalytic triad in OTUB2 rearrange and bring the active site into a catalytically feasible state. An analysis of water access channels revealed only a few diffusion trajectories for the catalytically active form of OTUB1, whereas in OTUB2 the catalytic site was solvent-accessible, and a larger number of water molecules reached and left the binding pocket. Interestingly, in OTUB2, the catalytic residues His224 and Asn226 formed a stable hydrogen bond. We propose that the observed differences in activation kinetics, protonation states, water channels, and active-site accessibility between OTUB1 and OTUB2 may be relevant for the selective design of OTU inhibitors.

scholarly journals Aldehyde dehydrogenase. An enzyme with two distinct catalytic activities at a single type of active site

1985 ◽  
Vol 230 (1) ◽  
pp. 261-267 ◽  
Author(s):  
R J Duncan
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Active Site ◽  
Active Sites ◽  
Catalytic Site ◽  
Single Type ◽  
Catalytic Activities ◽  
Binding Domains

The evidence for and against the esterase and dehydrogenase active sites of aldehyde dehydrogenase being topologically distinct is examined. It is found that all the evidence (including all that previously amassed by others in favour of distinct binding domains) is actually consistent with, and in favour of, a single type of catalytic site having both activities. The existence of separate high-Km modulating sites for the enzyme is also questioned.

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