scholarly journals Enzyme-activated probes in optical imaging: a focus on atherosclerosis

2021 ◽  
Author(s):  
Edward R. H. Walter ◽  
Saul M. Cooper ◽  
Joseph J. Boyle ◽  
Nicholas J. Long
Keyword(s):  
Optical Imaging ◽  
Atherosclerotic Plaque ◽  
Vulnerable Atherosclerotic Plaque ◽  
Design Requirements

This perspective provides an overview of the design requirements and fluorogenic mechanisms of enzyme-activatable probes in optical imaging, focusing particularly on detecting enzymatic targets overexpressed in vulnerable atherosclerotic plaque.

scholarly journals In vivo evaluation of vulnerable atherosclerotic plaque rabbit carotid model by optical coherence tomography

Heart ◽  
2011 ◽  
Vol 97 (Suppl 3) ◽  
pp. A17-A17
Author(s):  
S. Yanli ◽  
H. Sining ◽  
T. Jinwei ◽  
J. Haibo ◽  
M. Lingbo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Atherosclerotic Plaque ◽  
Optical Coherence ◽  
Vulnerable Atherosclerotic Plaque ◽  
In Vivo Evaluation

scholarly journals Simple Rabbit Model of Vulnerable Atherosclerotic Plaque

2009 ◽  
Vol 49 (8) ◽  
pp. 327-332 ◽  
Author(s):  
Takashi SHIMIZU ◽  
Kanji NAKAI ◽  
Yuji MORIMOTO ◽  
Miya ISHIHARA ◽  
Hidenori OISHI ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Rabbit Model ◽  
Vulnerable Atherosclerotic Plaque

Non-invasive imaging of the vulnerable atherosclerotic plaque

2021 ◽  
pp. 467-480
Author(s):  
Rong Bing ◽  
David E. Newby ◽  
Jagat Narula ◽  
Marc R. Dweck
Keyword(s):  
Atherosclerotic Plaque ◽  
Vulnerable Plaque ◽  
Plaque Rupture ◽  
Imaging Techniques ◽  
Risk Scores ◽  
Plaque Imaging ◽  
Vulnerable Atherosclerotic Plaque ◽  
Acute Thrombosis ◽  
Non Invasive ◽  
Clinical Events

Cardiovascular disease remains the leading cause of death globally despite advances in medical therapy and risk stratification; ischaemic heart disease was responsible for an estimated 9.5 million deaths in 2016. To address this ongoing global burden of morbidity and mortality, there is a need for more sophisticated methods of diagnosis and prognostication, above and beyond clinical risk scores alone. The majority of myocardial infarction occurs due to ruptured atherosclerotic plaque, leading to acute thrombosis and coronary occlusion. For decades, the concept of the vulnerable plaque—plaques prone to rupture or thrombotic complications—has been central to our understanding of the pathophysiology of acute coronary syndromes. More recently, there has been a shift towards identifying the vulnerable patient through assessment of total atherosclerotic disease burden, in recognition of the fact that most plaque rupture events do not lead to clinical events. Moreover, demonstrating a strong causal link between vulnerable plaques and clinical events has previously proven difficult due to limitations in available invasive and non-invasive imaging modalities. However, we now have an array of imaging techniques that hold great potential for the advancement of vulnerable plaque imaging. These modalities are the subject of state-of-the-art clinical research, aiming to develop the role of atherosclerotic plaque imaging in modern clinical practice and ultimately to improve patient outcomes.

scholarly journals Black blood vessel wall MRI to identify vulnerable atherosclerotic plaque in a non-stenotic intracranial vertebral artery as a cause of acute ischaemia

2020 ◽  
Vol 6 (4) ◽  
pp. 20200061
Author(s):  
Sundip Dhanvant Udani ◽  
Pervinder Bhogal
Keyword(s):  
Vertebral Artery ◽  
Atherosclerotic Plaque ◽  
Vessel Wall ◽  
Black Blood ◽  
Vulnerable Atherosclerotic Plaque ◽  
Acute Ischaemia ◽  
Neurological Sequelae ◽  
Intracranial Atherosclerotic Disease ◽  
Coronary Syndromes ◽  
Neuroimaging Techniques

Conventional neuroimaging techniques for investigating the cause of stroke are mainly centred on investigating luminal stenosis. The pathophysiology of intracranial atherosclerotic disease (ICAD) and stroke is complex and extends beyond just vessel narrowing. The concept of the vulnerable atherosclerotic plaque, that can result in acute coronary syndromes, has been well described in the cardiac literature 1,2 although this concept is less well accepted among stroke physicians. We describe a case of a 61-year-old male with acute neurological sequelae from a non-stenotic atherosclerotic plaque of the intracranial vertebral artery. This case report describes the additional use of vessel wall MRI techniques to aid the radiologist in identifying such vulnerable lesions and therefore helping to tailor management and prevent further clinical deterioration.

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