Directing group strategies in catalytic sp2 C–H cyanations: scope, mechanism and limitations

2021 ◽  
Author(s):  
Hui-cheng Cheng ◽  
Peng-hu Guo ◽  
Jiao-li Ma ◽  
Xiao-Qiang Hu
Keyword(s):  
Transition Metal ◽  
Direct Conversion ◽  
Group Strategy ◽  
Recent Developments ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Directing group strategy in transition metal catalyzed sp2 C–H bond cyanation has contributed to the direct conversion of hydrocarbons to cyano-containing compounds. Recent developments in transition metal-mediated sp2 C–H bond cyanation using this strategy are reviewed.

Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles

2018 ◽  
Vol 47 (11) ◽  
pp. 3861-3898 ◽  
Author(s):  
Vsevolod A. Peshkov ◽  
Olga P. Pereshivko ◽  
Anton A. Nechaev ◽  
Anatoly A. Peshkov ◽  
Erik V. Van der Eycken
Keyword(s):  
Transition Metal ◽  
Recent Developments ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations.

Directing-Group-Assisted Transition-Metal-Catalyzed Direct C–H Oxidative Annulation of Arenes with Alkynes for Facile Construction of Various Oxygen Heterocycles

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 993-1006 ◽  
Author(s):  
Guanghua Kuang ◽  
Guangyuan Liu ◽  
Xingxing Zhang ◽  
Naihao Lu ◽  
Yiyuan Peng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Noble Metals ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Research Papers ◽  
Recent Advances ◽  
Oxygen Heterocycles ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The most recent advances in the construction of oxygen heterocycles by the directing-group-assisted transition-metal-catalyzed direct oxidative annulation of arenes with diverse alkynes are summarized in this review. More than 140 recent research papers and many closely related reviews are referenced in this paper. Nine different oxygen heterocycles frameworks are discussed. Several traditional transition-metal catalysts as well as some classical non-noble metals are utilized to promote the annulation. Three plausible controlling models are disclosed to clarify the excellent regioselectivity outcomes achieved in case of unsymmetrical alkyne substrates.1 Introduction2 Coumarins3 I socoumarins and Their Analogues4 2-Pyrones and Their Analogues5 Chromones and Chroman-4-ones6 Chromenes and Isochromenes7 Fused Polycyclic Oxygen Heteroaromatics8 Benzofurans, Dihydrobenzofurans, and Furans9 Phthalides and Benzofuranones10 Benzoxepines11 Conclusion

Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines

2018 ◽  
Vol 54 (89) ◽  
pp. 12543-12560 ◽  
Author(s):  
P. M. Edwards ◽  
L. L. Schafer
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Protecting Group ◽  
Early Transition Metal ◽  
Directing Group ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Early Transition

Protecting group, directing group, and external oxidant free synthesis of structurally diverse amines.

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