scholarly journals New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

2021 ◽  
Author(s):  
Roger A. Sheldon ◽  
Alessandra Basso ◽  
Dean Brady
Keyword(s):  
Cost Effective ◽  
Continuous Processing ◽  
Enzyme Immobilisation ◽  
Recent Advances ◽  
Effective Use

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use in the bio-based economy and continuous processing in general.

Recent Advances in Drug Repurposing for Parkinson’s Disease

2019 ◽  
Vol 26 (28) ◽  
pp. 5340-5362 ◽  
Author(s):  
Xin Chen ◽  
Giuseppe Gumina ◽  
Kristopher G. Virga
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drug Discovery ◽  
De Novo ◽  
Drug Repositioning ◽  
Drug Repurposing ◽  
Cost Effective ◽  
New Drugs ◽  
Recent Advances ◽  
Clinical Drugs

:As a long-term degenerative disorder of the central nervous system that mostly affects older people, Parkinson’s disease is a growing health threat to our ever-aging population. Despite remarkable advances in our understanding of this disease, all therapeutics currently available only act to improve symptoms but cannot stop the disease progression. Therefore, it is essential that more effective drug discovery methods and approaches are developed, validated, and used for the discovery of disease-modifying treatments for Parkinson’s disease. Drug repurposing, also known as drug repositioning, or the process of finding new uses for existing or abandoned pharmaceuticals, has been recognized as a cost-effective and timeefficient way to develop new drugs, being equally promising as de novo drug discovery in the field of neurodegeneration and, more specifically for Parkinson’s disease. The availability of several established libraries of clinical drugs and fast evolvement in disease biology, genomics and bioinformatics has stimulated the momentums of both in silico and activity-based drug repurposing. With the successful clinical introduction of several repurposed drugs for Parkinson’s disease, drug repurposing has now become a robust alternative approach to the discovery and development of novel drugs for this disease. In this review, recent advances in drug repurposing for Parkinson’s disease will be discussed.

scholarly journals Recent Advances in Conventional Methods and Electrochemical Aptasensors for Mycotoxin Detection

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1437
Author(s):  
Jing Yi Ong ◽  
Andrew Pike ◽  
Ling Ling Tan
Keyword(s):  
Quantitative Analysis ◽  
Animal Feed ◽  
Cost Effective ◽  
Preventive Action ◽  
High Affinity ◽  
Recent Advances ◽  
Recognition Elements ◽  
Key Features ◽  
Pre Treatment ◽  
And Performance

The presence of mycotoxins in foodstuffs and feedstuffs is a serious concern for human health. The detection of mycotoxins is therefore necessary as a preventive action to avoid the harmful contamination of foodstuffs and animal feed. In comparison with the considerable expense of treating contaminated foodstuffs, early detection is a cost-effective way to ensure food safety. The high affinity of bio-recognition molecules to mycotoxins has led to the development of affinity columns for sample pre-treatment and the development of biosensors for the quantitative analysis of mycotoxins. Aptamers are a very attractive class of biological receptors that are currently in great demand for the development of new biosensors. In this review, the improvement in the materials and methodology, and the working principles and performance of both conventional and recently developed methods are discussed. The key features and applications of the fundamental recognition elements, such as antibodies and aptamers are addressed. Recent advances in aptasensors that are based on different electrochemical (EC) transducers are reviewed in detail, especially from the perspective of the diagnostic mechanism; in addition, a brief introduction of some commercially available mycotoxin detection kits is provided.

The socio-spatial politics of royalties and their distribution: A case study of the Surat Basin, Queensland

2021 ◽  
pp. 0308518X2110266
Author(s):  
Neil Argent ◽  
Sean Markey ◽  
Greg Halseth ◽  
Laura Ryser ◽  
Fiona Haslam-McKenzie
Keyword(s):  
Cost Effective ◽  
Indigenous Communities ◽  
Energy Extraction ◽  
Grant Application ◽  
Coal Seam Gas ◽  
Spatial Politics ◽  
Developmental Needs ◽  
Development Fund ◽  
Effective Use

This paper is concerned with the socio-spatial and ethical politics of redistribution, specifically the allocation of natural resources rents from political and economic cores to the economic and geographical peripheries whence the resource originated. Based on a case study of the coal seam gas sector in Queensland's Surat Basin, this paper focuses on the operation of the Queensland State Government's regional development fund for mining and energy extraction-affected regions. Employing an environmental justice framework, we critically explore the operation of these funds in ostensibly helping constituent communities in becoming resilient to the worst effects of the ‘staples trap’. Drawing on secondary demographic and housing data for the region, as well as primary information collected from key respondents from mid-2018 to early 2019, we show that funds were distributed across all of the local government areas, and allocated to projects and places primarily on a perceived economic needs basis. However, concerns were raised with the probity of the funds’ administration. In terms of recognition justice, the participation of smaller and more remote towns and local Indigenous communities was hampered by their structural marginalisation. Procedurally, the funds were criticised for the lack of local consultation taken in the development and approval of projects. While spatially concentrated expenditure may be the most cost-effective use of public monies, we argue that grant application processes should be open, transparent and inclusive, and the outcomes cognisant of the developmental needs of smaller communities, together with the need to foster regional solidarity and coherence.

Recent Advances on Visible-Light-Promoted Copper Catalysis in Organic Reactions

Synthesis ◽  
2021 ◽  
Author(s):  
Yang Xiong ◽  
Sijia Li ◽  
Haijing Xiao ◽  
Guozhu Zhang
Keyword(s):  
Visible Light ◽  
Copper Complexes ◽  
Rapid Development ◽  
Cost Effective ◽  
Organic Reactions ◽  
Copper Catalysis ◽  
Synthetic Chemistry ◽  
Recent Advances ◽  
Intense Activity

In recent years, visible-light-mediated copper photocatalysis have emerged as an attractive strategy for the diverse constructions of basic bonds in an ecologically benign and cost-effective fashion. The intense activity and increasing work of these areas stimulated the exploit of the distinctive properties of copper photocatalysis and the rapid development and expansion of their applications. In this review, we focus on introducing a series of significant achievements in copper complexes as standalone photocatalysis in organic reactions to make an attempt to exhibit their potential capabilities and high flexibilities in synthetic chemistry.

Recent Advances in the Incorporation of CO2 for C-H and C-C bond Functionalization

2021 ◽  
Author(s):  
Sandeep Pimparkar ◽  
Aishwarya K. Dalvi ◽  
Adithyaraj Koodan ◽  
Siddhartha Maiti ◽  
Shaeel Al-Thabaiti ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Carbon Dioxide ◽  
Thermodynamic Stability ◽  
Cost Effective ◽  
Bond Functionalization ◽  
Synthetic Organic Chemistry ◽  
Recent Advances ◽  
Carbon Dioxide Co2

Carbon dioxide (CO2) has emerged as one of the exciting cost-effective, abundant, and ready-to-use C1 sources in synthetic organic chemistry. However, the thermodynamic stability, as well as the kinetic inertness,...

scholarly journals EFFECTIVE USE OF ROTARY FURNACE SHELL HEAT

2014 ◽  
Vol 54 (6) ◽  
pp. 414-419
Author(s):  
Julius Lisuch ◽  
Dusan Dorcak ◽  
Jan Spisak
Keyword(s):  
Waste Heat ◽  
Cooling System ◽  
Raw Materials ◽  
Significant Proportion ◽  
Rotary Furnace ◽  
Cost Effective ◽  
Total Energy Expenditure ◽  
Heat Losses ◽  
Controlled Cooling ◽  
Effective Use

<pre><pre>Significant proportion of the total energy expenditure for the heat treatment of raw materials are heat losses through the shell of rotary furnace. Currently, the waste heat is not used in any way and escapes into the environment. Controlled cooling system for rotary furnace shell (<span>CCSRF</span>) is a new solution integrated into the technological process aimed at reducing the heat loss of the furnace shell. Based on simulations and experiments carried out was demonstrated a significant effect of controlled cooling shell to the rotary furnace work. The proposed solution is cost-effective and operationally undemanding.</pre></pre>

scholarly journals Rational, cost effective use of investigations

BMJ ◽  
2002 ◽  
Vol 325 (7357) ◽  
pp. 222a-222 ◽  
Author(s):  
S. Bulusu
Keyword(s):  
Cost Effective ◽  
Effective Use
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