Graphene Quantum Dots Obstruct the Membrane Axis of Alzheimer’s Amyloid Beta

2021 ◽  
Author(s):  
Huayuan Tang ◽  
Yuhuan Li ◽  
Aleksandr Kakinen ◽  
Nikolaos Andrikopoulos ◽  
Yunxiang Sun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quantum Dots ◽  
Amyloid Beta ◽  
Graphene Quantum Dots ◽  
Primary Form

Alzheimer’s disease (AD) is a primary form of dementia with debilitating consequences but no effective cure available. While the pathophysiology of AD remains multifactorial, the aggregation of amyloid beta (Aβ)...

Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease

2020 ◽  
Vol 11 (22) ◽  
pp. 3741-3748
Author(s):  
Kajal Tak ◽  
Rekha Sharma ◽  
Vivek Dave ◽  
Smita Jain ◽  
Swapnil Sharma
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Clitoria Ternatea

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

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