DPD Simulations on Mixed Polymeric DOX-loaded Micelles Assembled from PCL-SS-PPEGMA/ PDEA-PPEGMA and Their Dual pH/Reduction-responsive Release

2021 ◽  
Author(s):  
Zexiong Yang ◽  
Haiqian Zhao ◽  
Delin Wang ◽  
Li Yin ◽  
Kenxiang Cai ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Drug Loading ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Mixed Polymeric Micelles ◽  
Stimuli Response ◽  
Potential Strategy ◽  
Cancer Drug Delivery ◽  
Micellization Behavior

Mixed polymeric micelles by combination of two or more dissimilar polymers is a potential strategy to achieve multiple stimuli-response for anti-cancer drug delivery. However, their drug loading co-micellization behavior and...

Recent advances in polymeric micelles for anti-cancer drug delivery

2016 ◽  
Vol 83 ◽  
pp. 184-202 ◽  
Author(s):  
Swati Biswas ◽  
Preeti Kumari ◽  
Prit Manish Lakhani ◽  
Balaram Ghosh
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Cancer Drug ◽  
Recent Advances ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1899 ◽  
Author(s):  
Evgeny Apartsin ◽  
Nadezhda Knauer ◽  
Valeria Arkhipova ◽  
Ekaterina Pashkina ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Smart Vehicles ◽  
New Class ◽  
Self Assembling ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Reduction-responsive dithiomaleimide-based polymeric micelles for controlled anti-cancer drug delivery and bioimaging

2017 ◽  
Vol 8 (46) ◽  
pp. 7160-7168 ◽  
Author(s):  
Ting Bai ◽  
Junjie Du ◽  
Jianxin Chen ◽  
Xiao Duan ◽  
Qiang Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Tumor Cells ◽  
Disulfide Bonds ◽  
Polymeric Micelles ◽  
Amphiphilic Block Copolymers ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Model Drug ◽  
Cancer Drug Delivery

The biocompatible amphiphilic block copolymers and the CPT model drug were self-assembled into micelles with bright fluorescence and taken up by tumor cells. Then, the disulfide bonds in the micelles were cleaved to release CPT at a high GSH concentration.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

2018 ◽  
Vol 18 (2) ◽  
pp. 302-311
Author(s):  
Shulin Dai ◽  
Yucheng Feng ◽  
Shuyi Li ◽  
Yuxiao Chen ◽  
Meiqing Liu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Anti Cancer ◽  
Physical Interactions

Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles. Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

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