Understanding the close encounter of heme proteins with carboxylated multiwalled carbon nanotubes: A case study of contradictory stability trend for hemoglobin and myoglobin

2021 ◽  
Author(s):  
Sumit Kumar ◽  
Krishan Kumar ◽  
Ritu Yadav ◽  
Prasanna Ms Kukutla ◽  
Nagaraju Devunuri ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Multiwalled Carbon Nanotubes ◽  
Heme Proteins ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Close Encounter ◽  
Multiwalled Carbon

Carbon nanotubes (CNTs) are one of the unique and promising nanomaterials which possess plenty of applications such as biosensors, advanced drug delivery systems and biotechnology. CNTs bind rapidly with proteins...

Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

2013 ◽  
Vol 6 (3) ◽  
pp. 2113-2124
Author(s):  
Prashant Malik ◽  
Neha Gulati ◽  
Raj Kaur Malik ◽  
Upendra Nagaich
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Atomic Scale ◽  
Sustained Drug Delivery ◽  
Pharmaceutical Nanotechnology ◽  
Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.    

Novel drug delivery systems for natural extracts: The case study of Vitis Vinifera extract-SiO2 nanocomposites

2018 ◽  
Vol 551 (1-2) ◽  
pp. 84-96
Author(s):  
A. Scano ◽  
F. Ebau ◽  
M.L. Manca ◽  
V. Cabras ◽  
F. Cesare Marincola ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitis Vinifera ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Natural Extracts ◽  
Sio2 Nanocomposites ◽  
Novel Drug

scholarly journals EMERGING NOVEL NANOPHARMACEUTICALS FOR DRUG DELIVERY

2018 ◽  
Vol 11 (7) ◽  
pp. 35 ◽  
Author(s):  
Abishek Wadhwa ◽  
Vashish Mathura ◽  
Shaila Angela Lewis
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Adverse Effects ◽  
Public Interest ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Preparation Strategy ◽  
Novel Drug

Nanotechnology is an area of growing public interest. Employing nanotechnology in the field of drug delivery has led to the advent of nanopharmaceuticals. Nanopharmaceuticals are bound to surmount various obstacles that the field of pharmacy is currently facing by offering various advantages thereby, a promising potential to formulate advanced medicines with fewer adverse effects. Extensive research is in place, thus instigating the development of novel drug delivery systems, such as carbon nanotubes, nanosponges, nano wafers, and nanofibers, to name a few. Since their inception, these nanopharmaceuticals have advanced significantly regarding their preparation strategy and scope of applications. This article aims to review the merits, limitations, and scope of these aforementioned delivery systems.

Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽  
2015 ◽  
Vol 10 (01) ◽  
pp. 1550010 ◽  
Author(s):  
R. Afshari ◽  
S. Mazinani ◽  
M. Abdouss
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

Anticancer drug delivery systems based on noncovalent interactions between carbon nanotubes and linear–dendritic copolymers

Soft Matter ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. 4062 ◽  
Author(s):  
Mohsen Adeli ◽  
Farahman Hakimpoor ◽  
Masoumeh Ashiri ◽  
Roya Kabiri ◽  
Masoumeh Bavadi
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Noncovalent Interactions ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Pharmaceutical Applications of Carbon Nanotube-Mediated Drug Delivery Systems

2012 ◽  
Vol 5 (2) ◽  
pp. 1685-1696 ◽  
Author(s):  
Pradeep Kumar S ◽  
Prathibha D ◽  
Gowri Shankar N L ◽  
Parthibarajan R ◽  
Mastyagiri L ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Width Ratio ◽  
Wide Range

Carbon nanotubes, which are elongated fullerenes, resemble graphite sheets wrapped into cylinders with a high length-to-width ratio (few nm in diameter and up to 1 mm in length). Carbon nanotubes are molecular-scale tubes of graphitic carbon with outstanding properties. Carbon nanotubes have drawn great interest and attraction in the field of novel drug delivery system. Nanomedicines can target, diagnose, monitor and treat cancerous cell also. The small nanoscale dimension and astonishing properties make them a distinctive carrier with a wide range of promising applications. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. The various nano-size carrier systems are available for biotechnological applications including the drug delivery. Carbon nanotubes are typically used for bioactive delivery due to their some unique outstanding properties. Carbon nanotubes drug delivery system opens up new potential and possibilities over nanoparticles, dendrimers, liposomes etc. for biomedical applications and new drug delivery. In last few years, Carbon nanotubes (CNTs) have shown unexpected advantages in the field of cancer treatment and drug delivery systems. Present review article discuss in brief about the methods of synthesis, with purification as well as sorting techniques for giving different grades to different types of CNTs and biomedical applications. These show very good adsorption properties which helps in the detection of various chemicals, toxic agents etc. Research done using CNTs for cancer treatment is also discussed in brief.  

Theoretical formulation strategies towards neutralizing inter-individual variability associated with tacrolimus immunosuppressant therapy: a case study on next generation personalized medicine

2021 ◽  
Vol 22 ◽  
Author(s):  
Arun Radhakrishnan ◽  
Gowthamarajan Kuppusamy
Keyword(s):  
Drug Delivery ◽  
Personalized Medicine ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Individual Variability ◽  
Dose Titration ◽  
Next Generation ◽  
Pharmaceutical Industries ◽  
Novel Drug

: Individualizing drug therapy and attaining maximum benefits of a drug devoid of adverse reactions is the benefit of personalized medicine. One of the important factors contributing to inter-individual variability is genetic polymorphism. As of now, dose titration is the only followed golden standard for implementing personalized medicine. Converting the genotypic data into an optimized dose has become easier now due to technology development. However, for many drugs, finding an individualized dose may not be successful, which further leads to a trial and error approach. These dose titration strategies are generally followed at the clinical level, and so industrial involvement and further standardizations are not feasible. On the other side, technologically driven pharmaceutical industries have multiple smart drug delivery systems which are underutilized towards personalized medicine. Transdisciplinary research with drug delivery science can additionally support the personalization by converting the traditional concept of “dose titration towards personalization” with novel “dose-cum-dosage form modification towards next-generation personalized medicine”; the latter approach is useful to overcome gene-based inter-individual variability by either blocking, downregulating, or bypassing the biological protein generated by the polymorphic gene. This article elaborates an advanced approach to implement personalized medicine with the support of novel drug delivery systems. As a case study, we further reviewed the genetic polymorphisms associated with tacrolimus and customized novel drug delivery systems to overcome these challenges factored towards personalized medicine for better clinical outcomes, thereby paving a new strategy for implementing personalized medicine for all other drug candidates.

Intranuclear Drug Delivery and Effective in Vivo Cancer Therapy via Estradiol–PEG-Appended Multiwalled Carbon Nanotubes

2013 ◽  
Vol 10 (9) ◽  
pp. 3404-3416 ◽  
Author(s):  
Manasmita Das ◽  
Raman Preet Singh ◽  
Satyajit R. Datir ◽  
Sanyog Jain
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Multiwalled Carbon Nanotubes ◽  
Multiwalled Carbon
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