scholarly journals Retraction: Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis

2021 ◽  
Author(s):  
Shi-Yuan Zhao ◽  
Na Li ◽  
Wan-Yue Luo ◽  
Nan-Nan Zhang ◽  
Rong-Ye Zhou ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Chemical Synthesis ◽  
Antigenic Activity

Retraction of ‘Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis’ by Shi-Yuan Zhao et al., Chem. Commun., 2020, 56, 14067–14070, DOI: 10.1039/D0CC05573E.

Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis

2020 ◽  
Vol 56 (90) ◽  
pp. 14067-14070
Author(s):  
Shi-Yuan Zhao ◽  
Na Li ◽  
Wan-Yue Luo ◽  
Nan-Nan Zhang ◽  
Rong-Ye Zhou ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Chemical Synthesis ◽  
Antigenic Activity ◽  
Ifn Γ

Non-natural PIM epitope Ac2PIM2 was presented by CD1b to active T cell to release IFN-γ.

Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth

2019 ◽  
Vol 28 (11) ◽  
pp. 1838-1863 ◽  
Author(s):  
Shrinivas D. Joshi ◽  
S. R. Prem Kumar ◽  
Sonali Patil ◽  
M. Vijayakumar ◽  
Venkatarao H. Kulkarni ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Modeling ◽  
Chemical Synthesis ◽  
Pharmacophore Mapping ◽  
Pyrrole Derivatives

scholarly journals Synthetic protein conjugate vaccines provide protection against Mycobacterium tuberculosis in mice

2021 ◽  
Vol 118 (4) ◽  
pp. e2013730118
Author(s):  
Cameron C. Hanna ◽  
Anneliese S. Ashhurst ◽  
Diana Quan ◽  
Joshua W. C. Maxwell ◽  
Warwick J. Britton ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Chemical Synthesis ◽  
Burden Of Disease ◽  
Significant Protection ◽  
Preclinical Models ◽  
Conjugate Vaccines ◽  
Cell Responses ◽  
Vaccination Strategies ◽  
Protein Conjugate ◽  
Synthetic Protein

The global incidence of tuberculosis remains unacceptably high, with new preventative strategies needed to reduce the burden of disease. We describe here a method for the generation of synthetic self-adjuvanted protein vaccines and demonstrate application in vaccination against Mycobacterium tuberculosis. Two vaccine constructs were designed, consisting of full-length ESAT6 protein fused to the TLR2-targeting adjuvants Pam2Cys-SK4 or Pam3Cys-SK4. These were produced by chemical synthesis using a peptide ligation strategy. The synthetic self-adjuvanting vaccines generated powerful local CD4+ T cell responses against ESAT6 and provided significant protection in the lungs from virulent M. tuberculosis aerosol challenge when administered to the pulmonary mucosa of mice. The flexible synthetic platform we describe, which allows incorporation of adjuvants to multiantigenic vaccines, represents a general approach that can be applied to rapidly assess vaccination strategies in preclinical models for a range of diseases, including against novel pandemic pathogens such as SARS-CoV-2.

scholarly journals Synthesis of a homologous series of galactofuranose-containing mycobacterial arabinogalactan fragments

2016 ◽  
Vol 94 (11) ◽  
pp. 976-988 ◽  
Author(s):  
Maju Joe ◽  
Todd L. Lowary
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Chemical Synthesis ◽  
Mycolic Acid ◽  
Wall Structure ◽  
Complex Cell ◽  
Human Pathogen ◽  
Structural Element ◽  
Target Molecules ◽  
Mycobacterial Cell Wall

Mycobacteria, including the human pathogen Mycobacterium tuberculosis, the causative agent of tuberculosis, produce a complex cell wall structure made of carbohydrates and lipids. The major structural element of the mycobacterial cell wall is a glycoconjugate called the mycolic acid – arabinogalactan – peptidoglycan (mAGP) complex. Inhibition of mAGP biosynthesis is a proven strategy for developing anti-mycobacterial drugs, and thus, understanding the pathways and enzymes involved in the assembly of this molecule is of interest. In this paper, we describe the chemical synthesis of a panel of nine oligosaccharide fragments (4–12) of the galactan domain of the mAGP complex designed as biosynthetic probes. These structures, ranging in size from a hexasaccharide to a tetradecasaccharide, are potential substrates for two biosynthetic enzymes, GlfT2 and AftA, and represent the largest mycobacterial galactan fragments synthesized to date. The route developed was iterative and provided multimilligram quantities of the target molecules 4–12 in good overall yield.

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